Kansas City Chiefs vs Tennessee Titans Prediction, 12/21/2025 NFL Picks, Best Bets & Odds Week 16

Game: Kansas City Chiefs vs Tennessee Titans

Date: Sunday, December 21, 2025

Location: Nissan Stadium in Nashville, TN

TV: CBS

Odds-Point Spread: Titans (+3.5)

Total-Over-Under: 37.5

Nissan Stadium is the location where the Tennessee Titans (2-12) will meet the Kansas City Chiefs (6-8) on Sunday. Kansas City is 3.5-point favorites. The over-under is set at 37.5.

The Kansas City Chiefs head into this game 6-8 over the course of this year. In their last contest, the Chiefs played the Los Angeles Chargers and took a loss by a score of 16-13. Patrick Mahomes went 16-28 with 189 yards passing. He had a quarterback rate of 62.9 and finished the game with 1 interception. Isiah Pacheco was the leader on the ground for the Chiefs with 11 carries for 21 yds (1.9 yards per attempt). Travis Kelce had an average of 10.0 yards per catch by accumulating 70 yds on 7 receptions. The Kansas City Chiefs ended up rushing 21 times and accumulated 49 yds, which came out to an average of 2.3 yards per tote. When all was said and done, they tallied 54 plays which gave them 239 yds. Kansas City relinquished 19 pass completions on 29 tries for 201 yards, and a completion rate of 65.5%. Against the run, the Chiefs conceded 94 yards on 29 tries, which averages out to 3.2 yards per rush surrendered.

The Chiefs have earned 5,011 total yards this year. Kansas City has recorded 174 first downs offensively, and they have been called for 100 infractions for 837 total yards. When it comes to scoring touchdowns, Kansas City has attained 22 passing touchdowns and 15 touchdowns via the ground. They have given the ball away 13 different times (12 INTs and 1 fumble). As a team, they are sitting at 113.9 rushing yards giving them a rank of 20th in the league. When examining getting the ball into the endzone, the team representing Kansas City are averaging 23.4 points per outing.

The Chiefs sit 5th in the league in terms of their defensive prowess, relinquishing 19.1 points per outing. They are allowing an average of 4.0 yards per rushing attempt and 99.1 running yds per contest over the course of this year. Regarding passing yards, the Chiefs have relinquished 2,856 yds, which is good for 14th in the NFL. They have conceded 204.0 yds per contest via the pass, and are allowing a completion percentage of 67.6%. Altogether, they are allowing 303.1 yds per contest, which is good for 8th in the league. They have allowed 15 touchdowns by way of the pass, along with 12 touchdowns via the ground game. Overall, they have allowed 1,387 running yards through 14 contests on the season.

Get all of our NFL Picks Today

The Titans head into this matchup 2-12 on the year. The last time they stepped on the gridiron, the Titans took a loss by a final score of 37-24 when they faced the San Francisco 49ers. Cam Ward (2 touchdowns) finished the contest with 170 yards on 18-29 through the air while his quarterback rate was 101.2. He didn't throw any picks and his average yards per pass attempt was 5.9 yards. Chimere Dike was the top contributor in the passing game for the Titans, snagging 4 throws for 17 yards (4.3 yards per reception). Tony Pollard ran the football 14 times for 104 yards, walking away from the game with 7.4 yards per carry for Tennessee. The Titans finished with 306 yds while running 49 plays (6.2 yards per play). Tennessee ran the football for 6.8 yards per tote, finishing the game with 136 yds on 20 carries. Tennessee allowed 38 rush attempts for 138 yds (3.6 yards per carry). The Titans secondary conceded a completion percentage of 76.7%, relinquishing 292 yds on 23 for 30 through the air.

The Tennessee Titans have an average of 250.5 yds per contest, which is good for 31st in the league. They maintain an average of 88.6 rush yds per contest, and have carried the ball for 1,240 total yards. They have a total of 7 INTs while surrendering 10 fumbles lost, and have been able to tally 128 1st downs as a unit. The Tennessee offense has allowed 827 yards on 108 infractions, ranking this team at 4th in pro football regarding hurting your team. For the season, the Titans sit at 2,267 pass yds and have an average of 161.9 pass yds per contest, which has them ranked 31st in professional football. If you're looking at their scoring prowess, the Titans rank 31st in football, with an average of 16.1 PPG.

They have conceded 25 touchdowns via the pass plus 233.0 passing yards per contest, which is good for 25th in the league. Tennessee has relinquished a total of 1,730 rush yards (123.6 total yards per contest), and 19 touchdowns via the rush this year. The defense currently has 13 takeaways (7 forced fumbles and 6 INTs) on the year. All in all, they have relinquished 394 points. The Titans defense has taken part in 856 plays, which ranks 12th in the league. The Titans are surrendering 28.1 points per outing, ranking this team at 28th in pro football.

Who will win tonight's Chiefs-Titans NFL game against the spread?

Josh's Pick: Take the Titans +3.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get NFL picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.