Kyler Murray Prop Bets Today vs San Francisco 49ers 9/21/2025

Game: Arizona Cardinals vs San Francisco 49ers

Pass Yards Prop: 214 - Over (-111) Under (-115)

Completions Prop: 22 - Over (-113) Under (-113)

Pass Attempts Prop: 32 - Over (-102) Under (-125)

The Arizona Cardinals and Kyler Murray can be watched on FOX on Sunday, September 21, 2025 where they will try to defeat the San Francisco 49ers. Props open at 22 passing completions, 32 attempted passes, and 214 yards passing for Murray.

Kyler Murray Season Stats

He has notched 70 rush yards and holds an average of 191.5 passing yards per outing. Murray has an average of 27.0 pass attempts per contest (24th in pro football). For the year, the signal caller averages 70.4% concerning completion%. Kyler Murray has had a total of 383 pass yds. For the year, he ranks 13th in professional football regarding touchdown rate with 5.6%. Having a rank of 22nd in professional football, Murray averages 19.0 passing completions per outing and has amassed 3 passing TD's. Kyler Murray holds an average of 7.0 rush attempts per outing, has 1 INT, and 1.5 touchdowns through the air per outing.

Kyler Murray Last 5 Games

Murray holds an average of 23.2 passing completions per game in his last five contests and has notched 169 throwing attempts. In terms of throwing for 1st downs, the QB has notched 69 1st downs by air. The quarterback is averaging 229.6 passing yds per outing in his last 5 matchups. The QB has notched 9 touchdowns through the air and holds an average of 0.8 INTs per outing in his last five outings. The QB has been pretty solid when it comes to pick%, throwing an interception on 2.4% of his attempted passes while having earned an average of 13.9 1st downs through the air per outing.

Kyler Murray Last 10 Games

He is throwing an interception on 2.6% of his throwing attempts while averaging 6.4% for sack rate. In his last 10 contests, he has tallied 13 passing TD's and recorded 141 passing 1st downs. Along with maintaining an average of 34.3 throwing attempts per outing, Kyler has accumulated 241 passing completions. If you look at capability to hit a receiver en route to a score, the QB has an average of 1.3 passing TD's and 244.2 pass yards per outing. Over the course of his last 10 contests, Murray has an average of 24.1 passing completions per game. Kyler has an average of 70.3% if you look at throwing completions.

Kyler Murray Career Stats

When it comes to ability to run, Murray has amassed 31 rushing touchdowns. As well as recording 118 passing touchdowns, Kyler has an average of 2.0% regarding INT%. So far in his career, he has an average of 236.7 pass yards per outing. When it comes to throwing completions, the QB is getting a completion on 67.1% of his throwing attempts while earning an average of 4.2% on TD passes. Kyler Murray has tallied 2,834 pass attempts and amassed 58 interceptions thus far in his NFL career.

Arizona Cardinals Offense

The Arizona Cardinals have an average of 114.0 rush yards per outing and have accrued 38 completions on the year. If you analyze TD passes, the Cardinals currently sit 10th in professional football with a 5.6% TD%. When it comes to aptitude for moving the ball, the Arizona Cardinals have amassed 569 yards in total. When it comes to getting picked off, the Arizona Cardinals hold an average of 1.9%. The Arizona Cardinals have an average of 170.5 pass yards per outing on the year. The group who play their home games in State Farm Stadium have an average of 27.0 attempted passes and 284.5 yards in total per outing, giving them a rank of 26th in football.

San Francisco 49ers Defense

The 49ers are playing good concerning trying to stop running touchdowns, conceding 0.5 running touchdowns and 28.0 rushing attempts per outing. Apart from conceding 75 penalty yards, the San Francisco 49ers are conceding 1.5 touchdowns through the air per outing. The San Francisco 49ers are giving up 71.9% concerning limiting the other team from completing the ball, on top of conceding 41 passing completions. The 49ers have allowed 3 passing TD's (21st in pro football). The San Francisco 49ers are ranking 30th in professional football if you're looking at pick% surrendered with 0.0%. The San Francisco 49ers are playing superb concerning trying to stop pass yds per outing, conceding 166.0, and have yielded 205 rushing yds.

Guy Bruhn's Pick: Take the Over Passing Yards (-111)

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