Los Angeles Chargers vs Dallas Cowboys Prediction, 12/21/2025 NFL Picks, Best Bets & Odds Week 16

Game: Los Angeles Chargers vs Dallas Cowboys

Date: Sunday, December 21, 2025

Location: AT&T Stadium in Arlington, TX

TV: FOX

Odds-Point Spread: Cowboys (-2.5)

Total-Over-Under: 49.5

AT&T Stadium is the place where the Dallas Cowboys (6-7) will meet the Los Angeles Chargers (10-4) on Sunday. Los Angeles is 2.5-point dogs from oddsmakers. The over-under has been set at 49.5.

The Los Angeles Chargers step on the gridiron holding a record of 10-4 this year. The last time they stepped on the football field, the Chargers took the field against the Kansas City Chiefs and walked away with a win by a score of 16-13. Omarion Hampton led the offense in rushing for the Chargers with 15 carries for 61 yds (4.1 yards per carry). Keenan Allen had an average of 7.2 yards per reception by accounting for 36 yds on 5 catches. Justin Herbert went 19-29 with 210 yards through the air and 1 touchdown. He had a QB rate of 84 and finished the contest with 1 interception. When it came to stopping the run, the Chargers gave up 49 yards on 21 tries, which calculates to 2.3 yards per rush surrendered. Los Angeles relinquished 19 completions on 33 tries for 190 yards, and a completion percentage of 57.6%. When all was said and done, they had 58 plays which totaled 295 yards. The Los Angeles Chargers ended up rushing 29 times and recorded 94 yds, which earned them an average of 3.2 yards per carry.

Regarding getting the ball in the endzone, the AFC representatives have an average of 22.5 points per game. As a unit, they're sitting at 123.4 rush yds which ranks 11th in the league. The Chargers have notched 4,731 yards on the campaign. Los Angeles has a total of 152 first downs as an offense, and they have been called for 92 infractions for 703 yds. They have coughed up the ball 18 different times (12 picks and 6 lost fumbles). When you look at scoring touchdowns, Los Angeles currently has 23 passing TD's and 7 running touchdowns.

The Chargers currently rank 9th in the league regarding their defensive prowess, conceding 20.3 points per game. They are allowing an average of 4.5 yards per rushing attempt and 104.7 running yds per contest over the course of this year. If you're looking at passing yards, the Chargers have granted 2,441 total yards, ranking this team at 3rd in football. They have surrendered 174.4 total yards per contest via the pass, and are surrendering a completion% of 60.2%. All in all, they are allowing 279.1 yds per outing, which is good for 2nd in the NFL. They have surrendered 12 touchdowns via the pass, plus 16 touchdowns to rushers. Altogether, they have conceded 1,466 running yards through 14 contests for this campaign.

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The Cowboys come into this matchup holding a record of 6-7 this year. In their last game, the Cowboys took a loss by a final score of 34-26 when they played the Minnesota Vikings. Javonte Williams carried the rock 15 times for 91 yards, finishing the contest with 6.1 yards per carry for Dallas. CeeDee Lamb was the leading receiver for the Cowboys, catching 6 balls for 111 yards (18.5 yds per reception). Dak Prescott finished the contest with 294 yards on 23-38 through the air while his QB rating was 84.8. He didn't toss any picks and his average yards per pass attempt was 7.7 yds. Dallas surrendered 28 running attempts for 77 yds (2.8 yards per rush). The Cowboys pass defense gave up a completion rate of 62.5%, relinquishing 250 yards on 15 out of 24 passing. The Cowboys finished the contest with 423 yds on 67 plays (6.3 yards per play). Dallas ran the ball for 4.8 yds per attempt, finishing with a total of 138 yds on 29 attempts.

The Dallas Cowboys have an average of 396.9 yds per contest, which is good for 1st in the league. They have an average of 120.8 rushing yards per contest, and have carried the ball for 1,691 yds. They have tossed 11 picks while yielding 7 lost fumbles, and have been able to record 195 1st downs offensively. The Dallas offense has granted 913 total yards by way of 108 penalty flags, giving them a rank of 3rd in football when analyzing making mistakes. This season, the Cowboys have compiled 3,866 passing yards and have an average of 276.1 passing yards per game, which ranks 1st in the league. When you look at putting points on the board, the Cowboys currently sit 4th in the league, by scoring 29.1 points per game.

The Cowboys are giving up 30.0 PPG, which has them ranked 31st in professional football. They have surrendered 31 touchdowns via the pass plus 254.8 yards via the pass per contest, giving them a rank of 32nd in football. Dallas has surrendered a total of 1,682 rush yds (120.1 total yards per contest), along with 19 touchdowns via the ground game on the season. The Cowboys defense has taken the field for 871 plays from the line of scrimmage, giving them a rank of 20th in the league. The D has recorded 11 takeaways (5 forced fumbles and 6 INTs) over the course of this year. On the whole, they have relinquished 420 total points.

Who will win tonight's Chargers-Cowboys NFL game against the spread?

Guy's Pick: Take the Chargers +2.5

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