Los Angeles Chargers vs Las Vegas Raiders Prediction, 9/15/2025 NFL Picks, Best Bets & Odds Week 2

Game: Los Angeles Chargers vs Las Vegas Raiders

Date: Monday, September 15, 2025

Location: Allegiant Stadium in Las Vegas, NV

TV: ESPN

Odds-Point Spread: Raiders (3.5)

Total-Over-Under: 47

The Las Vegas Raiders (1-0) will play the Los Angeles Chargers (1-0) at Allegiant Stadium on Monday. Los Angeles opens this game as 3.5-point favorites. The over-under comes in at 47.

The Los Angeles Chargers step on the gridiron 1-0 over the course of this season. When they last took the field, the Chargers took on the Kansas City Chiefs and went home with a win by a final score of 27-21. Omarion Hampton was the rushing leader for the Chargers with 15 carries for 48 yards (3.2 yards per attempt). Keenan Allen left with an average of 9.7 yards per reception by earning 68 yds on 7 receptions. Justin Herbert went 25-34 with 318 yds passing and 3 TDs. He had a quarterback rate of 131.7 and finished the game without throwing a pick. When it came to stopping the run, the Chargers conceded 98 yds on 17 tries, which calculates to 5.8 yds per run allowed. Los Angeles allowed 24 pass completions on 39 tries for a total of 249 yards, and a completion percentage of 61.5%. In the game, they ran 59 plays which gave them a total of 394 yds. The Los Angeles Chargers ran the rock 25 different times and accounted for 90 yards, which is an average of 3.6 yards per carry.

If you're looking at getting the ball in the endzone, the Chargers average 27.0 points per game. Offensively, they're sitting at 90.0 rushing yds putting them 19th in pro football. The Chargers have racked up 394 total yards for this campaign. Los Angeles has notched 16 1st downs as an offense, and they have been hurt by 6 infractions for 49 yards. They haven't turned the ball over yet. If you're looking at putting points on the board, Los Angeles has compiled 3 touchdowns via the pass and 0 touchdowns via the run.

If you analyze yards via the pass, the Chargers have yielded 249 yds, which ranks them 24th in the NFL. They are relinquishing a completion percentage of 61.5%. They have relinquished 1 touchdown through the air, plus 1 touchdown by way of the ground game. In total, they are relinquishing 347.0 yards per outing, which ranks 22nd in professional football. They are allowing an average of 5.8 yards per run and 98.0 rushing yds per contest for this campaign. The Chargers are 19th in the NFL if you look at the opposition scoring, yielding 21.0 points per outing.

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The Raiders come into this game with a record of 1-0 on the campaign. In their last contest, the Raiders took home the win by a final score of 20-13 when they played the New England Patriots. Geno Smith (1 touchdown) finished the contest with 362 yards on 24-34 passing while his quarterback rating was 102.8. He threw 1 interception and his avg yards per attempt was 10.6 yards. Ashton Jeanty carried the rock 19 times for 38 yds, walking away from the contest with 2.0 yds per carry for Las Vegas. Jakobi Meyers was the leading receiver for the Raiders, snagging 8 passes for 97 yards (12.1 yards per reception). Las Vegas ended up running for 2.3 yards per carry, totaling 56 yards on 24 carries. The Raiders finished the contest with 389 yds while they ran 58 plays (6.7 yds per play). The Raiders secondary allowed a completion percentage of 65.2%, surrendering 276 yards on 30 out of 46 passing. Las Vegas allowed 18 rushing attempts for 60 yds (3.3 yds per rush).

The Las Vegas Raiders hold an average of 389.0 yds per game, putting them 7th in pro football. They have run for 56 total yards. The Las Vegas offense has surrendered 81 yards by way of 9 penalties, putting them 9th in the NFL when talking about hurting your team. In this season, the Raiders have thrown for 333 yards via the pass which has them ranked 2nd in the NFL. Concerning putting points on the board, the Raiders are ranked 16th in football, with an average of 20.0 points per contest.

They have surrendered 1 touchdown through the air as well as 276.0 passing yards per contest, ranking them 27th in football. Las Vegas has relinquished a total of 60 rushing yards. The D has racked up 1 turnover. The Raiders defense has taken part in 68 plays from the line of scrimmage, ranking them 25th in the NFL. The Raiders are surrendering 13.0 points per outing, ranking them 7th in the NFL.

Who will win tonight's Chargers-Raiders NFL game against the spread?

Tony's Pick: Take the Raiders +3.5

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