Los Angeles Chargers vs New York Giants Prediction, 9/28/2025 NFL Picks, Best Bets & Odds Week 4

Game: Los Angeles Chargers vs New York Giants

Date: Sunday, September 28, 2025

Location: MetLife Stadium in East Rutherford, NJ

TV: CBS

Odds-Point Spread: Giants (+6)

Total-Over-Under: 44.5

The Los Angeles Chargers (3-0) are traveling to MetLife Stadium on Sunday where they will attempt to beat the New York Giants (0-3). New York opens this matchup as 6-point dogs. The total comes in at 44.5.

The Los Angeles Chargers come into this game holding a record of 3-0 for this campaign. The last time they stepped on the gridiron, the Chargers took on the Denver Broncos and notched a win by a score of 23-20. Justin Herbert finished 28-47 with 300 yards passing and 1 touchdown. He had a QB rating of 76.6 and finished the game with 1 interception. Quentin Johnston had an average of 14.8 yards per catch by totaling 89 yards on 6 catches. Omarion Hampton was the leader on the ground for the Chargers with 19 carries for 70 yards (3.7 yds per carry). In the game, they ran 75 plays which gave them a total of 376 yds. The Los Angeles Chargers ended up rushing 28 times and totaled 106 yards, which came out to an average of 3.8 yds per carry. Against the run, the Chargers gave up 118 yds on 21 attempts, which averages out to 5.6 yards per run allowed. Los Angeles conceded 14 completions on 25 tries for a total of 147 yards, and a completion rate of 56.0%.

The Chargers have accumulated 1,087 yards over the course of this year. Los Angeles has amassed 41 first downs as a unit, and they have committed 15 penalties for 107 yards. If you look at scoring touchdowns, Los Angeles has produced 6 passing TD's and 1 rushing touchdown. They have turned the football over 3 times (1 interception and 2 fumbles). As a unit, they're averaging 92.3 rush yards which has them sitting 24th in the league. If you're looking at getting the ball in the endzone, the Chargers are averaging 23.3 PPG.

The Chargers currently rank 4th in pro football when examining their defensive abilities, surrendering 16.7 points per game. They are giving up 5.0 yds per running attempt and 94.7 rush yards per outing on the year. If you look at passing yards, the Chargers have given up 546 total yards, ranking this team at 9th in pro football. They have conceded 182.0 yards per outing via the pass, and are allowing a completion percentage of 57.9%. On the whole, they are giving up 276.7 yards per outing, which has them sitting 8th in the league. They have surrendered 2 touchdowns through the air, as well as 2 touchdowns on the ground. On the whole, they have conceded 284 running yards through 3 outings over the course of this year.

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The Giants head into this matchup 0-3 over the course of the season. In their last contest, the Giants went home defeated by a final of 22-9 when they played the Kansas City Chiefs. Russell Wilson finished the contest with 160 yds on 18-32 through the air while his quarterback rating was 43.7. He tossed 2 interceptions and his Y-A was 5.0 yds. Cam Skattebo was a featured target for the Giants, catching 6 passes for 61 yards (10.2 yards per catch). Cam Skattebo carried the football 10 times for 60 yds, walking away from the contest with 6.0 yds per carry for New York. The Giants ended up finishing with 281 yds on 59 plays (4.8 yards per play). New York rushed for 4.8 yds per attempt, finishing the contest with 130 yards on 27 carries. New York relinquished 28 rushing attempts for 105 yds (3.8 yards per carry). The Giants secondary allowed a completion rate of 59.5%, surrendering 201 yds on 22 for 37 passing.

When examining the points being put on the board, the Giants currently rank 27th in football, with an average of 17.3 PPG. On the season, the Giants have racked up 730 pass yards and hold an average of 243.3 pass yards per outing, which is good for 9th in professional football. They maintain an average of 96.0 rushing yards per game, and have toted the ball for 288 total yards. The New York Giants maintain an average of 339.3 yds per game, putting them 12th in the NFL. The New York offense has conceded 277 total yards by way of 27 penalty flags, which ranks them at 6th in the NFL concerning making mistakes. They have recorded 3 interceptions while conceding 0 fumbles, and have recorded 31 1st downs as an offense.

The Giants are yielding 27.7 points per contest, which is good for 24th in professional football. They have allowed 4 touchdowns via the pass as well as 252.0 yards via the pass per contest, which has them sitting 28th in pro football. New York has granted a total of 460 rush yards (153.3 yards per outing), and 5 touchdowns to runners for this campaign. The Giants defense has participated in 215 plays, which is 31st in the league. The D has attained 1 turnover on the year. On the whole, they have conceded 83 pts.

Who will win tonight's Chargers-Giants NFL game against the spread?

Tony's Pick: Take the Chargers -6

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