Los Angeles Rams vs Jacksonville Jaguars Prediction, 10/19/2025 NFL Picks, Best Bets & Odds Week 7
Game: Los Angeles Rams vs Jacksonville Jaguars
Date: Sunday, October 19, 2025
Location: Wembley Stadium in London, England
TV: NFL Net NFL+
Odds-Point Spread: Jaguars (+3)
Total-Over-Under: 45
The Jacksonville Jaguars (4-2) will try to defeat the Los Angeles Rams (4-2) at Wembley Stadium on Sunday. Jacksonville opens this matchup as 3-point underdogs. The betting total is set at 45.
The Los Angeles Rams head into this game 4-2 so far this season. In their last contest, the Rams took the field against the Baltimore Ravens and took home the win by a score of 17-3. Kyren Williams was the rushing leader for the Rams with 13 totes for 50 yds (3.8 yards per attempt). Tyler Higbee averaged 10.0 yds per reception by recording 40 yds on 4 catches. Matthew Stafford connected on 17-26 with 181 yards passing and 1 TD. He had a QB rating of 98.4 and walked away from the contest without throwing a pick. When it came to stopping the run, the Rams conceded 179 yds on 37 attempts, which averages out to 4.8 yards per run allowed. Los Angeles surrendered 21 completions on 34 attempts for a total of 117 yds, and a completion percentage of 61.8%. Overall, they had 49 plays which gave them a total of 241 yds. The Los Angeles Rams ended up running the ball 23 times and accounted for 74 yds, which earned them an average of 3.2 yards per attempt.

The Rams have compiled 2,250 yards so far this year. Los Angeles has racked up 78 1st downs offensively, and they have been called for 33 infractions for 269 yards. If you're looking at getting in the endzone, Los Angeles has attained 12 passing TD's and 4 TD's via the ground game. They have given the ball away 7 different times (2 interceptions and 5 fumbles). Collectively, they are sitting at 105.8 rushing yds ranking them 22nd in pro football. When talking about notching touchdowns, the NFC representatives average 23.3 points per contest.
If you analyze pass yards, the Rams have surrendered 1,194 yards, which ranks 11th in the league. They have surrendered 199.0 yards per game via the pass, and are allowing a completion percentage of 65.9%. In total, they have surrendered 647 yards on the ground through 6 contests so far this year. They have granted 7 touchdowns through the air, as well as 2 touchdowns on the ground. Altogether, they are allowing 306.8 yds per game, which has them ranked 8th in pro football. Opposing teams are running for an average of 3.8 yards per tote and 107.8 rushing yds per outing on the campaign. The Rams are ranked 3rd in the NFL when examining team defense, granting 18.3 PPG.
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The Jaguars step on the gridiron with a record of 4-2 over the course of this season. In their last game, the Jaguars took a defeat with a final score of 20-12 when they faced the Seattle Seahawks. Trevor Lawrence (2 TDs) ended the contest with 258 yds on 27-42 passing while his quarterback rate was 97.1. He didn't toss any picks and his average yards per pass attempt was 6.1 yds. Brian Thomas was the best receiver for the Jaguars, snagging 8 throws for 90 yds (11.3 yds per reception). Travis Etienne carried the ball 12 times for 27 yards, finishing the contest with 2.3 yds per carry for Jacksonville. The Jaguars finished the contest with a total of 273 yards and they ran 61 plays (4.5 yards per play). Jacksonville rushed the football for 3.1 yds per attempt, finishing the game with 59 yds on 19 carries. Jacksonville surrendered 26 rushing attempts for 60 yards (2.3 yards per carry). The Jaguars pass defense allowed a completion rate of 59.3%, surrendering 286 yards on 16 for 27 passing.
With reference to their scoring prowess, the Jaguars are ranking 17th in football, averaging 23.2 points per outing. So far this season, the Jaguars have a total of 1,242 pass yds and are sitting at 207.0 pass yds per contest, ranking them 15th in professional football. They maintain an average of 124.0 rushing yds per contest, and have carried the football for 744 total yards. The Jacksonville Jaguars maintain an average of 331.0 yards per game, which ranks 17th in the league. The Jacksonville offense has yielded 409 yards by way of 52 violations, which has them sitting 2nd in the league when it comes to hurting your team. They have thrown 5 INTs while yielding 1 fumble, and have been able to tally 63 1st downs as an offense.
The Jaguars are allowing 20.0 points per game, which has them ranked 9th in pro football. They have surrendered 10 touchdowns via the pass plus 256.3 pass yards per game, which ranks 30th in the league. Jacksonville has granted a total of 549 rush yards (91.5 yards per game), in addition to 4 touchdowns via the rush so far this season. The Jaguars defense has participated in 365 plays from the line of scrimmage, which has them ranked 19th in pro football. The defense has produced 14 turnovers over the course of this year. On the whole, they have granted 120 pts.
Who will win tonight's Rams-Jaguars NFL game against the spread?
Guy's Pick: Take the Jaguars +3
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Additional Resources:
Jacksonville Jaguars - Twitter
Los Angeles Rams - Twitter