Los Angeles Rams vs San Francisco 49ers Prediction, 11/9/2025 NFL Picks, Best Bets & Odds Week 10

Game: Los Angeles Rams vs San Francisco 49ers

Date: Sunday, November 9, 2025

Location: Levi's Stadium in Santa Clara, CA

TV: FOX

Odds-Point Spread: 49ers (+4)

Total-Over-Under: 49.5

The San Francisco 49ers (6-3) host the Los Angeles Rams (6-2) at Levi's Stadium on Sunday. Los Angeles opens this contest as 4-point favorites from Vegas oddsmakers. The betting total is set at 49.5.

The Los Angeles Rams step on the gridiron holding a record of 6-2 on the year. In their last contest, the Rams played the New Orleans Saints and walked away with a win by a score of 34-10. Matthew Stafford connected on 24-32 with 281 yards passing and 4 TDs. He had a QB rating of 140.8 and ended the contest with no picks. Puka Nacua held an average of 13.6 yds per catch by recording 95 yds on 7 catches. Kyren Williams was the leader on the ground for the Rams with 25 carries for 114 yds (4.6 yds per carry). On the day, they ran 75 plays for 438 yards. The Los Angeles Rams rushed the ball a total of 43 times and totaled 171 yds, which came out to an average of 4.0 yards per carry. Against the rush, the Rams gave up 57 yards on 14 tries, which is an average of 4.1 yds per rush surrendered. Los Angeles gave up 15 completions on 25 attempts for a total of 167 yds, and a completion rate of 60.0%.

When it comes to getting the ball into the endzone, the NFC West members average 26.1 PPG. As a team, they're averaging 111.9 rushing yds which is 18th in football. The Rams have collected 2,959 yards over the course of the season. Los Angeles has attained 106 1st downs as an offense, and they have been flagged for 41 penalties for 346 yards. They have surrendered the ball 7 different times (2 picks and 5 fumbles lost). Regarding scoring touchdowns, Los Angeles has attained 21 touchdowns via the pass and 5 touchdowns via the ground.

The Rams rank 2nd in football if you look at team defense, yielding 15.9 points per contest. They are allowing teams to run for an average of 3.9 yards per rush on the ground and 99.8 running yds per outing this season. In terms of yards via the pass, the Rams have relinquished 1,625 yards, which has them sitting 10th in football. They have conceded 203.1 yds per contest via the pass, and are surrendering a completion% of 62.3%. On the whole, they are yielding 302.9 total yards per game, which ranks 10th in football. They have surrendered 9 touchdowns by way of the pass, along with 2 touchdowns on the ground. Overall, they have relinquished 798 yards via the running game in 8 games this season.

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The 49ers head into this matchup 6-3 over the course of the season. The last time they stepped on the gridiron, the 49ers went home victorious with a score of 34-24 against the New York Giants. Christian McCaffrey carried the ball 28 times for 106 yds, ending the game with 3.8 yds per carry for San Francisco. Christian McCaffrey was featured in the passing game for the 49ers, snagging 5 balls for 67 yards (13.4 yards per catch). Mac Jones (2 touchdowns) walked away from the game with 235 yards on 19-24 passing while his QB rating was 135.2. He didn't toss any picks and his Y-A was 9.8 yards. San Francisco relinquished 21 attempts on the ground for 117 yards (5.6 yds per rush). The 49ers passing defense allowed a completion rate of 72.7%, surrendering 179 yds on 24 out of 33 passing. The 49ers finished the game with a total of 380 yds while running 63 plays (6.0 yds per play). San Francisco ran the ball for 4.1 yards per tote, finishing the contest with 159 yards on 39 attempts.

In terms of their scoring prowess, the 49ers are ranked 23rd in football, scoring 21.6 points per contest. On the year, the 49ers have racked up 2,295 pass yards and average 255.0 pass yards per outing, which ranks them at 5th in the NFL. They hold an average of 97.1 running yds per outing, and have run for 874 total yards. The San Francisco 49ers have an average of 352.1 total yards per game, which ranks 10th in football. The San Francisco offense has granted 422 yards by way of 54 infractions, putting them 20th in professional football when examining giving up free yards. They have recorded 9 picks while giving up 4 lost fumbles, and have been able to earn 123 1st downs offensively.

They have relinquished 15 touchdowns through the air and 223.7 pass yards per outing, which ranks them at 20th in football. San Francisco has granted a total of 980 running yds (108.9 total yards per outing), and 5 touchdowns via the rush this season. The D currently has 7 turnovers (6 fumbles forced and 1 interception) on the season. On the whole, they have allowed 188 points in total. The 49ers defense has taken the field for 549 plays, which has them sitting 23rd in football. The 49ers are granting 20.9 PPG, putting them 10th in professional football.

Who will win tonight's Rams-49ers NFL game against the spread?

Guy's Pick: Take the Rams -4

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