Los Angeles Rams vs Tennessee Titans Prediction, 9/14/2025 NFL Picks, Best Bets & Odds Week 2

Game: Los Angeles Rams vs Tennessee Titans

Date: Sunday, September 14, 2025

Location: Nissan Stadium in Nashville, TN

TV: CBS

Odds-Point Spread: Titans (+5.5)

Total-Over-Under: 42

The Los Angeles Rams (1-0) are on their way to Nissan Stadium on Sunday where they will try to defeat the Tennessee Titans (0-1). Tennessee opens this contest as 5.5-point dogs from Vegas oddsmakers. The total comes in at 42.

The Los Angeles Rams head into this matchup 1-0 on the year. The last time they took the field, the Rams took the field against the Houston Texans and went home with a win by a final score of 14-9. Matthew Stafford connected on 21-29 with 245 yards passing and 1 TD. He had a quarterback rate of 109.1 and walked away from the game with no picks. Puka Nacua averaged 13.0 yds per catch by accounting for 130 yards on 10 catches. Kyren Williams was the best rusher for the Rams with 18 carries for 66 yards (3.7 yards per carry). In the game, they ran 54 plays for 296 yds. The Los Angeles Rams ran the ball a total of 25 different times and had 72 yds, which came out to an average of 2.9 yards per tote. When it came to stopping the run, the Rams gave up 114 yards on 27 tries, which averages out to 4.2 yards per rush surrendered. Los Angeles conceded 19 pass completions on 27 attempts for 151 yards, and a completion rate of 70.4%.

If you look at putting the ball in the endzone, the group who plays in Los Angeles are sitting at 14.0 points per game. As a unit, they hold an average of 72.0 rushing yds which ranks them 24th in the NFL. The Rams have accumulated 296 yards for the year. Los Angeles has a total of 13 first downs as an offense, and they have been called for 7 infractions for 60 yards. They have turned the ball over 1 time. If you're looking at scoring touchdowns, Los Angeles has compiled 1 passing touchdown and 1 rushing touchdown.

The Rams are ranking 3rd in pro football when analyzing their defensive abilities, yielding 9.0 points per game. They are allowing an average of 4.2 yards per run and 114.0 rushing yards per game for the year. If you analyze yards via the pass, the Rams have yielded 151 yds, which ranks them 9th in the NFL. They are surrendering a completion percentage of 70.4%. Overall, they are conceding 265.0 yards per contest, ranking them 10th in football. They have yet to give up a touchdown

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The Titans come into this game with a record of 0-1 on the campaign. The last time they stepped on the gridiron, the Titans took a loss by a score of 20-12 against the Denver Broncos. Cam Ward ended the game with 112 yds on 12-28 passing while his quarterback rating was 54.5. He didn't throw any picks and his avg yards per attempt was 4.0 yds. Calvin Ridley was featured in the passing game for the Titans, hauling in 4 passes for 27 yards (6.8 yds per catch). Tony Pollard ran the ball 18 times for 60 yards, finishing the contest with 3.3 yds per attempt for Tennessee. The Titans finished the game with a total of 133 yards while they ran 49 plays (2.7 yards per play). Tennessee ran for 3.4 yards per carry, finishing with 71 yards on 21 carries. Tennessee conceded 30 run attempts for 151 yds (5.0 yds per rush). The Titans secondary gave up a completion rate of 62.5%, surrendering 166 yards on 25 out of 40 through the air.

The Tennessee Titans average 133.0 yds per contest, putting them 32nd in pro football. They have run for 71 total yards. The Tennessee offense has conceded 131 yds on 13 penalty flags, ranking them 2nd in the NFL if you look at helping out the other team. This year, the Titans sit at 62 pass yards which is 32nd in football. If you analyze how much they score, the Titans currently rank 28th in the NFL, maintaining an average of 12.0 points per game.

The Titans are surrendering 20.0 points per outing, ranking them 18th in the NFL. They have yielded 1 touchdown via the pass as well as 166.0 yards through the air per outing, which has them ranking 12th in the league. Tennessee has allowed a total of 151 running yds. The Titans defense has taken part in 71 plays from the line of scrimmage, ranking them 30th in the NFL. The D has tallied 4 takeaways.

Who will win tonight's Rams-Titans NFL game against the spread?

Guy's Pick: Take the Rams -5.5

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