Miami Dolphins vs Indianapolis Colts Prediction, 9/7/2025 NFL Picks, Best Bets & Odds Week 1

Game: Miami Dolphins vs Indianapolis Colts

Date: Sunday, September 7, 2025

Location: Lucas Oil Stadium in Indianapolis, IN

TV: CBS

Odds-Point Spread: Colts (-1.5)

Total-Over-Under: 47

The Miami Dolphins (8-9 last season) are headed to Lucas Oil Stadium on Sunday where they will take on the Indianapolis Colts (8-9 last year). Miami opens this contest as 1.5-point dogs from Vegas oddsmakers. The over-under is 47.

The Miami Dolphins finished the year holding a 8-9 record. In their last contest, the Dolphins played against the New York Jets and walked away from this one with a loss by a score of 32-20. Tyler Huntley finished 25-41 with 227 yds passing and 1 TD. He had a QB rating of 63.8 and walked away from the game with 2 picks. De'Von Achane was the best rusher for the Dolphins with 11 attempts for 121 yards (11.0 yards per attempt). Jonnu Smith left with an average of 6.2 yards per catch by recording 56 yards on 9 receptions. The Miami Dolphins ran the ball 23 different times and recorded 135 yds, which earned them an average of 5.9 yards per tote. In all, they tallied 64 plays which gave them a total of 334 yards. Miami surrendered 23 completions on 37 attempts for 257 yards, and a completion percentage of 62.2%. When it came to the battle of the line of scrimmage, the Dolphins gave up 118 yards on 22 tries, which is 5.4 yds per run allowed.

If you're looking at notching touchdowns, the AFC East members held an average of 20.3 points per contest. As a unit, they maintained an average of 105.6 rushing yards, which had them ranking 21st in football. The Dolphins accrued 5,532 yards for the previous season. Miami accumulated 221 1st downs as a unit, and they were flagged for 114 infractions for 926 yards. They coughed up the ball 21 different times (10 picks and 11 lost fumbles). Miami notched 22 passing TD's and 12 touchdowns on the ground.

The Dolphins ranked 10th in the NFL if you examine the other team scoring points, relinquishing 21.4 points per game. They allowed 4.4 yards per attempt on the ground and 103.7 rushing yds per contest for last year. Overall, they surrendered 1,763 yards via the running game in 17 contests for the previous season. When it comes to passing yds, the Dolphins allowed 3,582 total yards which ranked them 9th in professional football. They surrendered 210.7 total yards per contest via the pass, and yielded a completion percentage 63.8%. Overall, they allowed 314.4 per outing, which was 4th in professional football. They relinquished 22 TD's through the air, as well as 12 via the rush.

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The Colts ended the year having amassed a 8-9 mark. In their last game, the Colts got the victory with a final of 26-23 against the Jacksonville Jaguars. Joe Flacco (1 TD) finished the game with 264 yards on 23-40 passing while his QB rating was 85.8. He didn't toss any picks and his average yds per pass attempt was 6.6 yards. Jonathan Taylor ran the ball 34 times for 177 yds, walking away from the contest with 5.2 yds per attempt for Indianapolis. Josh Downs was a featured target for the Colts, catching 10 balls for 94 yards (9.4 yds per catch). Indianapolis ended up running for 5.2 yards per carry, totaling 177 yds on 34 carries. The Colts finished the game with 429 yards and they ran 74 plays (5.8 yards per play). The Colts pass defense gave up a completion percentage of 62.5%, surrendering 206 yds on 20 out of 32 through the air. Indianapolis conceded 34 rush attempts for 113 yards (3.3 yards per carry).

When it comes to putting points on the board, the Colts sat 17th in professional football, holding an average of 22.2 points per contest. Last year, the Colts threw for a total of 3,361 passing yds and held an average of 197.7 passing yds per contest, which had them ranked 25th in the NFL. They held an average of 137.1 rushing yards per contest, and carried the football for 2,331 total yards. The Indianapolis Colts had an average of 334.8 yds per contest, ranking them 13th in football. The Indianapolis offense surrendered 684 yds by way of 93 infractions, which had them sitting 30th in the NFL if you examine making mistakes.

They allowed 27 touchdowns via the pass plus 229.4 passing yds per outing, which had them ranking 26th in professional football. Indianapolis granted a total of 2,241 rushing yds (131.8 total yards per contest), along with 18 touchdowns via the rush for last year. Their defense compiled 25 turnovers (9 fumbles forced and 16 picks) in the previous season. The Colts defense participated in 1,112 plays, which ranked 29th in professional football. The Colts granted 25.1 points per game, which had them sitting 24th in the NFL.

Who will win tonight's Dolphins-Colts NFL game against the spread?

Guy's Pick: Take the Dolphins +1.5

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