New England Patriots vs New Orleans Saints Prediction, 10/12/2025 NFL Picks, Best Bets & Odds Week 6

Game: New England Patriots vs New Orleans Saints

Date: Sunday, October 12, 2025

Location: Caesars Superdome in New Orleans, LA

TV: CBS

Odds-Point Spread: Saints (+3.5)

Total-Over-Under: 46

The New Orleans Saints (1-4) will take on the New England Patriots (3-2) at Caesars Superdome on Sunday. New Orleans opens this game as 3.5-point underdogs from Vegas oddsmakers. The total has been set at 46.

The New England Patriots head into this game 3-2 so far this season. In their last contest, the Patriots played the Buffalo Bills and took home the win by a score of 23-20. Drake Maye went 22-30 with 273 yds passing. He had a quarterback rating of 101.1 and walked away from the game without throwing a pick. Rhamondre Stevenson was the rushing leader for the Patriots with 7 attempts for 14 yds (2.0 yards per carry). Stefon Diggs had an average of 14.6 yards per catch by earning 146 yds on 10 receptions. The New England Patriots ran the ball 22 times and tallied 71 yds, which is an average of 3.2 yds per attempt. When all was said and done, they had 52 plays which converted into 338 yards. New England gave up 22 completions on 31 attempts for a total of 245 yards, and a completion percentage of 71.0%. In the running game, the Patriots gave up 118 yards on 29 attempts, which averages out to 4.1 yards per rush surrendered.

When talking about scoring points, the AFC East representatives hold an average of 25.0 PPG. Offensively, they are averaging 95.2 rush yds ranking this team at 27th in the NFL. The Patriots have a total of 1,683 total yards for the year. New England has tallied 58 1st downs as a unit, and they have been hurt by 42 infractions for 346 yds. They have given the ball to the opposition 7 times (2 picks and 5 fumbles lost). In terms of putting the ball in the endzone, New England has recorded 7 passing TD's and 6 rushing touchdowns.

Concerning yards through the air, the Patriots have granted 1,211 yards, which is 27th in professional football. They have relinquished 242.2 yds per outing by way of the pass, and are conceding a completion% of 71.2%. In total, they have conceded 428 running yards through 5 outings so far this season. They have conceded 9 touchdowns by way of the pass, and 2 touchdowns by way of the ground game. Altogether, they are allowing 327.8 yds per outing, putting them 18th in pro football. They are giving up an average of 3.5 yds per run and 85.6 running yds per contest over the course of the season. The Patriots are 10th in professional football when it comes to the other team scoring points, granting 20.2 points per contest.

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The Saints head into this matchup 1-4 on the campaign. When they last stepped on the football field, the Saints walked away with a victory by a final of 26-14 against the New York Giants. Spencer Rattler (1 TD) finished the contest with 225 yards on 21-31 through the air while his quarterback rate was 99.5. He didn't throw any interceptions and his average yards per pass attempt was 7.3 yards. Kendre Miller carried the football 10 times for 41 yds, ending the game with 4.1 yds per carry for New Orleans. Chris Olave was the best receiver for the Saints, hauling in 7 passes for 59 yards (8.4 yards per reception). New Orleans rushed for 2.9 yards per attempt, finishing with 88 yards on 30 carries. The Saints finished the contest with a total of 332 yards while running 62 plays (5.4 yards per play). The Saints pass defense gave up a completion rate of 65.0%, relinquishing 199 yards on 26 out of 40 through the air. New Orleans gave up 29 rush attempts for 136 yds (4.7 yds per rush).

The New Orleans Saints hold an average of 307.2 yards per game, which is 24th in professional football. They have an average of 116.8 running yards per game, and have carried the ball for 584 yds. They have allowed 2 interceptions while granting 1 fumble, and have earned 53 1st downs. The New Orleans offense has allowed 295 total yards by way of 42 penalties, which ranks 9th in pro football when you look at helping out the other team. On the campaign, the Saints have thrown for 952 yards through the air and are sitting at 190.4 yards through the air per contest, which has them sitting 25th in professional football. Regarding their ability to score points, the Saints currently sit 27th in football, holding an average of 18.4 points per contest.

The Saints are giving up 27.0 points per contest, ranking this team at 24th in the NFL. They have relinquished 11 touchdowns by way of the pass along with 204.0 pass yards per outing, putting them 9th in pro football. New Orleans has relinquished a total of 611 rushing yards (122.2 yds per outing), along with 4 touchdowns by way of the ground game for the year. The Saints defense has taken part in 310 plays from scrimmage, putting them 21st in pro football. The defense has amassed 8 turnovers (5 forced fumbles and 3 picks) for the year. Overall, they have relinquished 135 pts.

Who will win tonight's Patriots-Saints NFL game against the spread?

Josh's Pick: Take the Saints +3.5

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