New Orleans Saints vs Carolina Panthers Prediction, 11/9/2025 NFL Picks, Best Bets & Odds Week 10

Game: New Orleans Saints vs Carolina Panthers

Date: Sunday, November 9, 2025

Location: Bank of America Stadium in Charlotte, NC

TV: FOX

Odds-Point Spread: Panthers (-5.5)

Total-Over-Under: 40

The Carolina Panthers (5-4) will take on the New Orleans Saints (1-8) at Bank of America Stadium on Sunday. New Orleans opens this contest as 5.5-point underdogs. The total is set at 40.

The New Orleans Saints come into this game holding a record of 1-8 on the season. When they last stepped on the football field, the Saints faced off with the Los Angeles Rams and took a loss by a final of 34-10. Tyler Shough finished 15-24 with 176 yards passing and 1 TD. He had a quarterback rating of 81.2 and finished the game with 1 pick. Alvin Kamara led the offense in rushing for the Saints with 6 carries for 14 yards (2.3 yards per carry). Rashid Shaheed left with an average of 13.6 yds per catch by earning 68 yards on 5 receptions. The New Orleans Saints ran the ball 14 times and amassed 57 yards, which is an average of 4.1 yds per carry. On the day, they had 39 plays which gave them a total of 224 yards. New Orleans conceded 24 pass completions on 32 attempts for a total of 267 yards, and a completion rate of 75.0%. In the running game, the Saints gave up 171 yards on 43 attempts, which averages out to 4.0 yds per run allowed.

If you look at notching touchdowns, the New Orleans Saints average 15.3 points per outing. Collectively, they're averaging 89.6 running yards which has them sitting 27th in football. The Saints have tallied 2,584 total yards on the year. New Orleans has attained 90 1st downs as an offense, and they have been flagged for 68 penalties for 465 yards. They have given the ball to the opposition 14 different times (8 interceptions and 6 fumbles). When it comes to getting the ball into the endzone, New Orleans has notched 9 passing TD's and 3 touchdowns on the ground.

If you look at pass yards, the Saints have given up 1,835 total yards, which ranks them at 18th in the NFL. They have allowed 203.9 total yards per game via the pass, and are granting a completion rate of 68.3%. On the whole, they have allowed 1,165 yards on the ground through 9 contests over the course of the season. They have allowed 18 touchdowns via the pass, plus 8 touchdowns via the rush. Altogether, they are surrendering 333.3 yds per contest, giving them a rank of 18th in the NFL. The opposition is running for an average of 4.0 yards per rush and 129.4 running yds per outing this season. The Saints are ranked 25th in football when analyzing the other team scoring points, conceding 27.0 PPG.

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The Panthers step onto the field with a record of 5-4 for the year. The last time they took the field, the Panthers took home the win by a final score of 16-13 against the Green Bay Packers. Bryce Young finished the contest with 102 yards on 11-20 passing while his quarterback rate was 48.3. He had 1 pick and his average yards per pass attempt was 5.1 yards. Tetairoa McMillan was one of the featured targets for the Panthers, grabbing 4 footballs for 46 yds (11.5 yds per catch). Rico Dowdle carried the rock 25 times for 130 yards, ending the contest with 5.2 yards per attempt for Carolina. The Panthers finished the contest with 265 yards while running 53 plays (5.0 yds per play). Carolina ran the football for 4.9 yards per carry, finishing the game with 163 yards on 33 attempts. Carolina relinquished 25 run attempts for 104 yards (4.2 yds per rush). The Panthers passing defense conceded a completion rate of 70.3%, surrendering 265 yards on 26 for 37 through the air.

If you're looking at putting points on the board, the Panthers are ranked 27th in football, with an average of 18.9 points per contest. In this season, the Panthers have earned 1,538 passing yds and average 170.9 passing yds per contest, putting them 30th in professional football. They hold an average of 139.8 running yards per contest, and have carried the football for 1,258 yards. The Carolina Panthers average 310.7 total yards per outing, which ranks them at 22nd in the NFL. The Carolina offense has conceded 409 yards on 51 violations, which has them sitting 26th in football when talking about giving up free yards. They have allowed 7 picks while conceding 6 lost fumbles, and have been able to earn 95 1st downs.

They have relinquished 11 touchdowns by way of the pass and 205.8 yards via the pass per contest, which has them sitting 15th in football. Carolina has relinquished a total of 997 running yds (110.8 total yards per outing), and 10 touchdowns via the rush this season. Their defense has accumulated 9 takeaways (2 fumbles forced and 7 picks) over the course of the season. In total, they have relinquished 205 total points. The Panthers defense has been on the field for 514 plays from the line of scrimmage, giving them a rank of 19th in the NFL. The Panthers are conceding 22.8 points per contest, which ranks them 16th in the league.

Who will win tonight's Saints-Panthers NFL game against the spread?

Guy's Pick: Take the Panthers -5.5

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