New York Giants vs Detroit Lions Prediction, 11/23/2025 NFL Picks, Best Bets & Odds Week 12

Game: New York Giants vs Detroit Lions

Date: Sunday, November 23, 2025

Location: Ford Field in Detroit, MI

TV: FOX

Odds-Point Spread: Lions (-10.5)

Total-Over-Under: 50.5

Ford Field is the location where the Detroit Lions (6-4) will attempt to beat the New York Giants (2-9) on Sunday. Detroit opens this game as 10.5-point favorites from oddsmakers. The betting total is set at 50.5.

The New York Giants step on the gridiron holding a record of 2-9 so far this year. When they last stepped on the football field, the Giants stepped onto the field against the Green Bay Packers and ended up losing by a score of 27-20. Jameis Winston connected on 19-29 with 201 yds passing. He had a QB rate of 71.2 and finished the game with 1 interception. Isaiah Hodgins held an average of 11.4 yds per reception by earning 57 yards on 5 catches. Tyrone Tracy Jr. was the best rusher for the Giants with 19 carries for 88 yds (4.6 yds per carry). On the day, they ran 67 plays which converted into 336 yds. The New York Giants ended up running the ball 38 different times and compiled 142 yards, which had them averaging 3.7 yds per attempt. On the ground, the Giants conceded 128 yards on 23 tries, which is 5.6 yards per run surrendered. New York relinquished 15 pass completions on 26 attempts for 168 yards, and a completion percentage of 57.7%.

When talking about scoring touchdowns, the team who plays in New York have an average of 21.5 PPG. As a unit, they're maintaining an average of 124.7 running yards which has them ranking 10th in the league. The Giants have collected 3,665 yards for this campaign. New York has collected 104 first downs offensively, and they have been hurt by 85 penalties for 729 yds. They have turned the football over 12 times (7 INTs and 5 fumbles lost). When talking about getting in the endzone, New York has collected 13 passing TD's and 16 touchdowns via the ground.

The Giants are 29th in the league when it comes to team defense, relinquishing 27.3 points per contest. Opposing teams are running for an average of 5.5 yards per attempt on the ground and 149.9 rush yds per contest on the campaign. Regarding passing yds, the Giants have relinquished 2,477 total yards, putting them 27th in pro football. They have given up 225.2 yards per game through the air, and are surrendering a completion% of 64.0%. Overall, they are yielding 375.1 yds per game, ranking this team at 29th in pro football. They have given up 19 touchdowns through the air, and 15 touchdowns on the ground. Altogether, they have yielded 1,649 rushing yards through 11 contests for this campaign.

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The Lions come into this game with a record of 6-4 over the course of this year. In their last contest, the Lions walked away with a loss by a score of 16-9 when they faced the Philadelphia Eagles. Jahmyr Gibbs carried the rock 12 times for 39 yards, ending the contest with 3.3 yds per carry for Detroit. Jahmyr Gibbs was a featured target for the Lions, bringing in 5 footballs for 107 yds (21.4 yds per reception). Jared Goff (1 TD) walked away from the game with 255 yards on 14-37 through the air while his quarterback rating was 60.1. He threw 1 pick and his average yards per pass attempt was 6.9 yds. Detroit relinquished 40 run attempts for 148 yds (3.7 yards per carry). The Lions secondary allowed a completion percentage of 50.0%, surrendering 124 yds on 14 for 28 through the air. The Lions ended up finishing with 317 yds and they ran 58 plays (5.5 yds per play). Detroit ran for 3.5 yards per tote, finishing the contest with 74 yards on 21 attempts.

The Detroit Lions have an average of 366.9 yds per contest, which has them sitting 5th in football. They average 130.1 rush yards per game, and have rushed for 1,301 yards. They have compiled 4 INTs while giving up 3 lost fumbles, and have obtained 124 1st downs. The Detroit offense has conceded 440 total yards on 60 penalties, putting them 26th in pro football when it comes to helping out the opposition. Over the course of this season, the Lions have a total of 2,368 yards via the pass and hold an average of 236.8 yards via the pass per game, which has them ranking 9th in football. When you look at putting points on the board, the Lions sit 5th in the league, by tallying 29.2 points per outing.

They have allowed 18 touchdowns via the pass as well as 192.1 pass yards per game, ranking this team at 8th in pro football. Detroit has allowed a total of 997 rush yards (99.7 yards per game), along with 8 touchdowns to runners so far this year. The defense has attained 12 turnovers (4 fumbles forced and 8 interceptions) on the campaign. Overall, they have given up 216 total points. The Lions defense has been on the field for 595 plays from scrimmage, ranking this team at 6th in the league. The Lions are granting 21.6 points per game, which is good for 10th in the league.

Who will win tonight's Giants-Lions NFL game against the spread?

Parlays Pundit's Pick: Take the Lions -10.5 and over 50.5 total points

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