San Francisco 49ers vs Cleveland Browns Prediction, 11/30/2025 NFL Picks, Best Bets & Odds Week 13

Game: San Francisco 49ers vs Cleveland Browns

Date: Sunday, November 30, 2025

Location: Huntington Bank Field in Cleveland, OH

TV: CBS

Odds-Point Spread: Browns (+5)

Total-Over-Under: 38

The San Francisco 49ers (8-4) are on their way to Huntington Bank Field on Sunday where they will try to beat the Cleveland Browns (3-8). San Francisco opens this contest as 5-point favorites from Vegas oddsmakers. The over-under comes in at 38.

The San Francisco 49ers step on the gridiron holding a record of 8-4 for the year. The last time they stepped on the gridiron, the 49ers went up against the Carolina Panthers and walked away with a win by a score of 20-9. Brock Purdy connected on 23-32 with 193 yards passing and 1 TD. He had a quarterback rating of 58.5 and walked away from the game with 3 picks. Christian McCaffrey was the best rusher for the 49ers with 24 carries for 89 yds (3.7 yds per carry). Christian McCaffrey averaged 7.6 yards per reception by totaling 53 yards on 7 catches. The San Francisco 49ers ended up running the ball 38 times and recorded 147 yards, which is an average of 3.9 yards per attempt. For the game, they ran 70 plays for 340 yards. San Francisco surrendered 18 pass completions on 29 attempts for a total of 161 yds, and a completion percentage of 62.1%. Against the rush, the 49ers gave up 69 yds on 13 attempts, which averages out to 5.3 yds per rush allowed.

The 49ers have collected 4,183 total yards over the course of this year. San Francisco has recorded 163 first downs as an offense, and they have been called for 64 penalties for 488 yds. When you look at getting the ball in the endzone, San Francisco currently has 21 passing touchdowns and 9 running touchdowns. They have surrendered the football 18 times (13 interceptions and 5 fumbles lost). As a unit, they have an average of 99.2 running yards which is 26th in the league. When examining notching touchdowns, the NFC West representatives have an average of 23.4 points per contest.

When you look at passing yds, the 49ers have yielded 2,901 yds, which ranks 32nd in professional football. They have surrendered 241.8 yds per game via the pass, and are allowing a completion% of 69.4%. On the whole, they have yielded 1,211 yards on the ground through 12 matchups over the course of this season. They have surrendered 22 touchdowns via the pass, and 8 touchdowns on the ground. On the whole, they are granting 342.7 yards per contest, which is 22nd in pro football. They are giving up an average of 4.1 yds per run and 100.9 rushing yards per contest so far this year. The 49ers are ranking 11th in professional football when examining their defensive abilities, yielding 21.8 points per outing.

Get all of our NFL Picks this Week

The Browns head into this matchup 3-8 this season. The last time they stepped on the gridiron, the Browns walked away with a victory by a final of 24-10 when they faced the Las Vegas Raiders. Shedeur Sanders (1 TD) finished the contest with 209 yds on 11-20 through the air while his quarterback rate was 87.3. He tossed 1 pick and his Y-A was 10.5 yards. Harold Fannin was one of the featured targets for the Browns, catching 4 balls for 40 yards (10.0 yards per reception). Quinshon Judkins carried the football 16 times for 47 yds, finishing the game with 2.9 yds per attempt for Cleveland. The Browns finished the game with 270 yds while running 47 plays (5.7 yards per play). Cleveland ran for 2.4 yards per carry, finishing the game with 64 yds on 27 attempts. Cleveland conceded 21 attempts on the ground for 60 yds (2.9 yards per carry). The Browns passing defense gave up a completion rate of 68.2%, surrendering 208 yds on 30 out of 44 through the air.

The Cleveland Browns average 258.5 yards per contest, which is 31st in pro football. They maintain an average of 94.9 running yards per outing, and have carried the football for 1,044 total yards. They have thrown 10 INTs while granting 3 lost fumbles, and have tallied 86 first downs offensively. The Cleveland offense has conceded 615 total yards on 76 penalties, which ranks 17th in the league when you look at giving up free yards. In this campaign, the Browns have thrown for 1,799 yards via the pass and average 163.5 yards via the pass per outing, which ranks 31st in the league. If you're looking at how much they score, the Browns currently sit 29th in the league, holding an average of 16.9 points per game.

The Browns are surrendering 22.2 points per contest, which is good for 13th in professional football. They have relinquished 17 touchdowns by way of the pass plus 170.7 pass yds per contest, which has them sitting 2nd in the NFL. Cleveland has allowed a total of 1,125 running yds (102.3 yds per outing), along with 5 touchdowns to runners over the course of this season. The Browns defense has taken the field for 642 plays, which has them sitting 5th in the league. The D has produced 15 takeaways (6 forced fumbles and 9 interceptions) on the year. In total, they have given up 244 pts.

Who will win tonight's 49ers-Browns NFL game against the spread?

Guy's Pick: Take the 49ers -5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get NFL picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.