San Francisco 49ers vs Houston Texans Prediction, 10/26/2025 NFL Picks, Best Bets & Odds Week 8

Game: San Francisco 49ers vs Houston Texans

Date: Sunday, October 26, 2025

Location: NRG Stadium in Houston, TX

TV: FOX

Odds-Point Spread: Texans (-1.5)

Total-Over-Under: 41.5

NRG Stadium is where the Houston Texans (2-4) will try to defeat the San Francisco 49ers (5-2) on Sunday. Houston is 1.5-point favorites. The total is 41.5.

The San Francisco 49ers step on the gridiron 5-2 for the year. In their last contest, the 49ers took on the Atlanta Falcons and notched a win by a score of 20-10. Mac Jones went 17-26 with 152 yds passing. He had a QB rating of 64.9 and finished the contest with 1 pick. Christian McCaffrey was the rushing leader for the 49ers with 24 attempts for 129 yards (5.4 yards per attempt). Kendrick Bourne left with an average of 7.0 yards per catch by accounting for 14 yds on 2 receptions. The San Francisco 49ers ended up rushing 39 times and accumulated 174 yards, which earned them an average of 4.5 yards per attempt. On the day, they tallied 65 plays which gave them a total of 324 yards. San Francisco surrendered 21 pass completions on 38 tries for a total of 230 yds, and a completion rate of 55.3%. When it came to the battle of the line of scrimmage, the 49ers conceded 62 yds on 20 attempts, which averages out to 3.1 yards per run allowed.

The 49ers have recorded 2,566 yds over the course of this year. San Francisco has recorded 100 1st downs as an offense, and they have been flagged for 44 penalties for 358 yds. When it comes to notching touchdowns, San Francisco has recorded 10 passing TD's and 3 ground TD's. They have surrendered the ball 11 times (8 interceptions and 3 fumbles lost). Collectively, they're holding an average of 95.3 rushing yds which is 25th in pro football. When examining getting in the endzone, the NFC representatives have an average of 20.7 PPG.

The 49ers are ranked 7th in the NFL if you're looking at their defensive abilities, allowing 19.7 PPG. They are allowing an average of 4.0 yds per rush and 100.9 running yards per contest so far this year. When you look at passing yards, the 49ers have given up 1,516 yds, giving them a rank of 19th in football. They have given up 216.6 yds per game through the air, and are allowing a completion% of 65.8%. Altogether, they are relinquishing 317.4 yds per outing, giving them a rank of 14th in football. They have yielded 11 touchdowns via the pass, as well as 4 touchdowns via the ground game. All in all, they have given up 706 rushing yards through 7 outings over the course of this year.

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The Texans head into this matchup 2-4 for the year. When they last took the field, the Texans took a loss by a final score of 27-19 when they played the Seattle Seahawks. C.J. Stroud (1 touchdown) ended the game with 229 yards on 23-49 through the air while his quarterback rate was 59. He tossed 1 pick and his avg yards per attempt was 4.7 yards. C.J. Stroud carried the ball 2 times for 25 yds, ending the game with 12.5 yds per attempt for Houston. Braxton Berrios was the best receiver for the Texans, bringing in 1 footballs for -1 yds (-1.0 yds per catch). Houston ran for 3.3 yards per attempt, finishing with a total of 56 yds on 17 carries. The Texans finished the game with 254 yds and they ran 66 plays (3.8 yards per play). The Texans secondary conceded a completion rate of 53.1%, relinquishing 198 yds on 17 for 32 passing. Houston surrendered 33 rush attempts for 118 yds (3.6 yards per carry).

The Houston Texans maintain an average of 304.3 total yards per outing, ranking this team at 23rd in the NFL. They hold an average of 106.2 running yards per outing, and have rushed for 637 yds. They have compiled 4 interceptions while yielding 2 fumbles lost, and have been able to record 59 first downs. The Houston offense has allowed 372 yards by way of 44 infractions, ranking this team at 25th in the NFL if you're looking at helping out the other team. In this season, the Texans sit at 1,189 passing yards and average 198.2 passing yards per outing, giving them a rank of 23rd in football. If you look at this team's ability to score points, the Texans currently sit 21st in the NFL, maintaining an average of 21.2 points per contest.

They have granted 4 touchdowns through the air plus 179.0 yards via the pass per contest, which is good for 5th in football. Houston has allowed a total of 571 rush yds (95.2 yds per outing), as well as 7 touchdowns by way of the ground game over the course of this year. The defense has collected 10 turnovers (3 forced fumbles and 7 interceptions) over the course of this season. Overall, they have granted 88 pts. The Texans defense has taken part in 348 plays from the line of scrimmage, ranking them 5th in the league. The Texans are relinquishing 14.7 points per game, giving them a rank of 1st in football.

Who will win tonight's 49ers-Texans NFL game against the spread?

Guy's Pick: Take the Texans -1.5

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