San Francisco 49ers vs Los Angeles Rams Prediction, 10/2/2025 NFL Picks, Best Bets & Odds Week 5

Game: San Francisco 49ers vs Los Angeles Rams

Date: Thursday, October 2, 2025

Location: SoFi Stadium in Inglewood, CA

TV: Prime Video

Odds-Point Spread: Rams (-5.5)

Total-Over-Under: 47

The San Francisco 49ers (3-1) are headed to SoFi Stadium on Thursday where they will try to defeat the Los Angeles Rams (3-1). Los Angeles opens this contest as 5.5-point favorites from Vegas oddsmakers. The total has been set at 47.

The San Francisco 49ers step on the gridiron 3-1 for this campaign. In their last game, the 49ers played the Jacksonville Jaguars and ended up losing by a score of 26-21. Brock Purdy finished 22-38 with 309 yards through the air and 2 TDs. He had a quarterback rate of 79.8 and finished the contest with 2 picks. Christian McCaffrey had an average of 15.3 yds per catch by accounting for 92 yards on 6 catches. Christian McCaffrey was the best rusher for the 49ers with 17 carries for 49 yds (2.9 yds per carry). When all was said and done, they had 62 plays which totaled 389 yards. The San Francisco 49ers ran the football 24 times and recorded 83 yds, which had them averaging 3.5 yds per attempt. When it came to the battle of the line of scrimmage, the 49ers conceded 151 yards on 32 attempts, which is an average of 4.7 yds per run allowed. San Francisco relinquished 21 pass completions on 31 tries for 174 yards, and a completion percentage of 67.7%.

If you examine getting the ball in the endzone, the NFC representatives average 20.0 points per outing. Offensively, they're sitting at 88.0 rushing yds putting them 28th in the NFL. The 49ers have a total of 1,472 yards on the year. San Francisco has tallied 61 1st downs as a unit, and they have been called for 24 penalties for 224 total yards. They have given the ball to the opposition 8 different times (5 INTs and 3 fumbles). In terms of putting points on the board, San Francisco currently has 8 passing TD's and 0 touchdowns via the ground.

The 49ers rank 7th in professional football regarding opponents scoring, relinquishing 18.8 points per outing. The opposition is running for 4.0 yds per running attempt and 115.5 rushing yds per game on the season. In terms of pass yds, the 49ers have granted 660 yds, which ranks them 6th in pro football. They have given up 165.0 yds per contest through the air, and are yielding a completion rate of 68.3%. Overall, they are surrendering 280.5 total yards per game, which is 6th in football. They have relinquished 5 touchdowns via the pass, and 2 touchdowns via the ground game. Overall, they have allowed 462 rushing yards through 4 games for the season.

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The Rams come into this matchup holding a record of 3-1 for the year. In their last game, the Rams walked away with a victory by a final of 27-20 against the Indianapolis Colts. Matthew Stafford (3 touchdowns) ended the game with 375 yards on 29-41 passing while his quarterback rating was 123.5. He didn't toss any picks and his Y-A was 9.1 yards. Kyren Williams carried the rock 13 times for 77 yards, ending the contest with 5.9 yds per attempt for Los Angeles. Puka Nacua was a featured target for the Rams, hauling in 13 passes for 170 yds (13.1 yards per catch). Los Angeles ran the football for 3.9 yds per attempt, finishing with a total of 102 yards on 26 attempts. The Rams ended up finishing with 462 yds and they ran 67 plays (6.9 yards per play). The Rams pass defense conceded a completion rate of 72.7%, relinquishing 248 yds on 24 out of 33 through the air. Los Angeles surrendered 21 rushing attempts for 85 yards (4.0 yds per carry).

The Los Angeles Rams average 388.3 total yards per game, which is good for 4th in professional football. They have an average of 120.8 rushing yards per outing, and have carried the football for 483 yards. They have recorded 2 picks while surrendering 2 fumbles lost, and have recorded 50 first downs as a team. The Los Angeles offense has relinquished 193 total yards on 22 penalties, which is good for 28th in professional football when examining making mistakes. This year, the Rams have earned 1,070 passing yds and hold an average of 267.5 passing yds per outing, which is 3rd in football. When you look at this team's ability to score points, the Rams are ranking 13th in pro football, with an average of 25.0 points per contest.

The Rams are yielding 20.3 points per outing, which is good for 10th in professional football. They have conceded 5 touchdowns through the air as well as 186.0 yards through the air per contest, putting them 10th in the league. Los Angeles has conceded a total of 394 rushing yards (98.5 yards per contest), as well as 2 touchdowns via the rush on the year. The Rams defense has been on the field for 240 plays, which is good for 14th in professional football. The defense has notched 7 turnovers (4 fumbles forced and 3 interceptions) on the season. Overall, they have given up 81 total points.

Who will win tonight's 49ers-Rams NFL game against the spread?

Tony's Pick: Take the 49ers +5.5

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