Seattle Seahawks vs Arizona Cardinals Prediction, 9/25/2025 NFL Picks, Best Bets & Odds Week 4

Game: Seattle Seahawks vs Arizona Cardinals

Date: Thursday, September 25, 2025

Location: State Farm Stadium in Glendale, AZ

TV: Prime Video

Odds-Point Spread: Cardinals (-1)

Total-Over-Under: 43.5

State Farm Stadium is where the Arizona Cardinals (2-1) will attempt to defeat the Seattle Seahawks (2-1) on Thursday. Seattle is 1-point dogs. The over-under comes in at 43.5.

The Seattle Seahawks head into this game 2-1 so far this year. When they last stepped on the football field, the Seahawks took the field against the New Orleans Saints and earned the victory with a final of 44-13. Sam Darnold finished 14-18 with 218 yards passing and 2 TDs. He had a QB rate of 154.2 and ended the game with no interceptions. Jaxon Smith-Njigba averaged 19.2 yds per reception by tallying 96 yards on 5 receptions. Kenneth Walker III was the leader on the ground for the Seahawks with 16 carries for 38 yards (2.4 yds per carry). At the end of the game, they had 54 plays for 320 yds. The Seattle Seahawks rushed the ball a total of 33 times and totaled 87 yards, earning them an average of 2.6 yards per tote. In the running game, the Seahawks gave up 79 yards on 27 tries, which averages out to 2.9 yards per run allowed. Seattle surrendered 28 pass completions on 41 attempts for 205 yds, and a completion rate of 68.3%.

The Seahawks have amassed 945 yards for this campaign. Seattle has attained 30 first downs as a team, and they have been hurt by 14 infractions for 110 yds. If you look at getting in the endzone, Seattle has recorded 4 passing touchdowns and 4 touchdowns via the ground. They have surrendered the football 5 different times (2 picks and 3 fumbles lost). As a unit, they're holding an average of 96.0 rushing yards which ranks them 21st in football. When examining getting in the endzone, the NFC members have an average of 29.3 points per outing.

The Seahawks currently rank 2nd in pro football when examining their defensive abilities, surrendering 15.7 points per game. They are allowing 3.2 yds per running attempt and 90.0 rushing yds per game this year. If you look at passing yards, the Seahawks have given up 665 total yards, ranking this team at 20th in pro football. They have allowed 221.7 total yards per contest through the air, and are giving up a completion percentage of 66.7%. On the whole, they are giving up 311.7 yards per contest, which is 14th in the league. They have yielded 4 touchdowns through the air. All in all, they have relinquished 270 yards via the ground game in 3 matchups so far this year.

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The Cardinals step on the gridiron with a record of 2-1 over the course of this year. The last time they stepped on the gridiron, the Cardinals took a loss by a score of 16-15 when they played the San Francisco 49ers. Trey Benson ran the ball 10 times for 42 yds, ending the game with 4.2 yds per attempt for Arizona. Marvin Harrison Jr. was a featured target for the Cardinals, snagging 3 footballs for 44 yards (14.7 yards per catch). Kyler Murray (1 TD) ended the contest with 159 yards on 22-35 through the air while his quarterback rating was 82.9. He didn't throw any picks and his average yds per pass attempt was 4.5 yards. Arizona relinquished 20 running attempts for 73 yards (3.7 yds per rush). The Cardinals pass defense allowed a completion rate of 65.9%, relinquishing 282 yds on 27 for 41 passing. The Cardinals finished the game with a total of 260 yards and they ran 63 plays (4.1 yards per play). Arizona ended up running for 3.8 yds per attempt, finishing the game with 106 yards on 28 attempts.

The Arizona Cardinals maintain an average of 276.3 total yards per game, which ranks them 25th in football. They average 111.3 rush yards per contest, and have run for 334 total yards. They have compiled 1 interception while giving up 0 fumbles lost, and have obtained 29 first downs as a unit. The Arizona offense has surrendered 180 total yards on 26 violations, which has them sitting 10th in pro football when examining hurting your team. On the season, the Cardinals have racked up 495 pass yards and hold an average of 165.0 pass yards per outing, which is good for 28th in professional football. Regarding their ability to score points, the Cardinals are ranked 19th in the NFL, by scoring 20.7 PPG.

They have relinquished 4 touchdowns via the pass in addition to 264.3 passing yds per game, putting them 30th in the NFL. Arizona has surrendered a total of 229 rush yards (76.3 total yards per contest), as well as 1 touchdown on the ground for this campaign. The D has recorded 3 takeaways (1 fumble and 2 interceptions) for this campaign. All in all, they have conceded 51 points in total. The Cardinals defense has participated in 208 plays from the line of scrimmage, which has them sitting 30th in pro football. The Cardinals are yielding 17.0 PPG, which ranks them at 5th in the NFL.

Who will win tonight's Seahawks-Cardinals NFL game against the spread?

Tony's Pick: Take the Seahawks +1

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