Tennessee Titans vs Arizona Cardinals Prediction, 10/5/2025 NFL Picks, Best Bets & Odds Week 5

Game: Tennessee Titans vs Arizona Cardinals

Date: Sunday, October 5, 2025

Location: State Farm Stadium in Glendale, AZ

TV: CBS

Odds-Point Spread: Cardinals (-8.5)

Total-Over-Under: 41.5

The Arizona Cardinals (2-2) are welcoming the Tennessee Titans (0-4) at State Farm Stadium on Sunday. Arizona is 8.5-point favorites from oddsmakers. The betting total is set at 41.5.

The Tennessee Titans come into this game holding a record of 0-4 this year. In their last game, the Titans took on the Houston Texans and took a loss by a final of 26-0. Cam Ward finished 10-26 with 108 yards passing. He had a quarterback rate of 35.4 and finished the game with 1 interception. Tony Pollard averaged 4.0 yds per reception by recording 12 yds on 3 receptions. Tony Pollard was the rushing leader for the Titans with 14 carries for 64 yards (4.6 yards per carry). Once the final whistle blew, they ran 44 plays which gave them 175 yards. The Tennessee Titans ended up running the ball 18 different times and accounted for 82 yards, earning them an average of 4.6 yards per tote. In the running game, the Titans conceded 129 yards on 35 attempts, which is an average of 3.7 yards per run allowed. Tennessee allowed 22 pass completions on 28 tries for a total of 224 yards, and a completion percentage of 78.6%.

The Titans have racked up 842 yds on the season. Tennessee has amassed 31 first downs as a team, and they have been called for 35 penalties for 296 yards. When examining getting in the endzone, Tennessee has tallied 2 passing TD's and 1 rushing touchdown. They have surrendered the football 5 different times (2 interceptions and 3 fumbles). Offensively, they're sitting at 87.0 rushing yds putting them 29th in the NFL. In terms of scoring, the AFC members are sitting at 12.8 points per outing.

The Titans rank 29th in professional football regarding opponents scoring, relinquishing 30.0 points per outing. They are giving up 4.8 yards per run and 141.5 rushing yds per contest so far this year. In terms of pass yds, the Titans have granted 908 yds, which ranks them 22nd in pro football. They have allowed 227.0 yards per contest by way of the pass, and are relinquishing a completion% of 69.8%. All in all, they are giving up 368.5 yds per contest, which ranks them 25th in pro football. They have conceded 6 touchdowns by way of the pass, plus 7 touchdowns by way of the ground game. On the whole, they have conceded 566 yards on the ground through 4 outings for this campaign.

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The Cardinals come into this matchup holding a record of 2-2 for the season. When they last stepped on the football field, the Cardinals walked away with a loss by a score of 23-20 against the Seattle Seahawks. Kyler Murray (2 TDs) finished the game with 200 yds on 27-41 passing while his quarterback rating was 73.2. He tossed 2 picks and his average yds per pass attempt was 4.9 yds. Trey Benson carried the rock 8 times for 35 yards, ending the contest with 4.4 yds per attempt for Arizona. Trey McBride was featured in the passing game for the Cardinals, grabbing 7 throws for 52 yards (7.4 yds per catch). Arizona ran the football for 5.2 yds per carry, finishing the game with 89 yards on 17 carries. The Cardinals finished with 253 yds on 58 plays (4.4 yds per play). The Cardinals pass defense gave up a completion percentage of 69.2%, surrendering 229 yds on 18 for 26 passing. Arizona surrendered 35 running attempts for 155 yards (4.4 yds per rush).

The Arizona Cardinals average 270.5 total yards per game, which is good for 28th in professional football. They average 105.8 rushing yds per game, and have toted the ball for 423 total yards. They have a total of 3 picks while yielding 0 fumbles lost, and have been able to record 42 first downs as a team. The Arizona offense has granted 226 total yards on 33 violations, which is 9th in football if you examine hurting your team. On the season, the Cardinals have thrown for a total of 659 yards via the pass and hold an average of 164.8 yards via the pass per contest, putting them 28th in football. In terms of how much they score, the Cardinals rank 22nd in professional football, holding an average of 20.5 points per outing.

They have surrendered 5 touchdowns via the pass in addition to 255.5 passing yds per game, which is good for 28th in professional football. Arizona has surrendered a total of 384 rushing yds (96.0 total yards per game), in addition to 2 touchdowns via the rush for the year. The defense has a total of 4 takeaways (2 fumbles forced and 2 INTs) for the year. On the whole, they have conceded 74 points. The Cardinals defense has participated in 272 plays from scrimmage, which has them ranked 30th in the NFL. The Cardinals are surrendering 18.5 points per outing, which is 6th in football.

Who will win tonight's Titans-Cardinals NFL game against the spread?

Josh's Pick: Take the Titans +8.5

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