Tennessee Titans vs Houston Texans Prediction, 9/28/2025 NFL Picks, Best Bets & Odds Week 4

Game: Tennessee Titans vs Houston Texans

Date: Sunday, September 28, 2025

Location: NRG Stadium in Houston, TX

TV: CBS

Odds-Point Spread: Texans (-7)

Total-Over-Under: 39

The Tennessee Titans (0-3) are traveling to NRG Stadium on Sunday where they will attempt to beat the Houston Texans (0-3). Houston is 7-point favorites. The betting total is set at 39.

The Tennessee Titans head into this matchup 0-3 over the course of this season. In their last game, the Titans faced off with the Indianapolis Colts and ended up losing by a score of 41-20. Tony Pollard was the rushing leader for the Titans with 16 carries for 45 yards (2.8 yds per carry). Chigoziem Okonkwo held an average of 13.2 yards per reception by accumulating 66 yds on 5 receptions. Cam Ward went 23-38 with 219 yards through the air and 1 TD. He had a quarterback rating of 74.3 and ended the game with 1 pick. On the ground, the Titans conceded 137 yards on 28 tries, which calculates to 4.9 yards per run allowed. Tennessee gave up 18 pass completions on 25 tries for a total of 228 yds, and a completion percentage of 72.0%. Overall, they tallied 61 plays which gave them 282 yards. The Tennessee Titans ended up rushing 23 times and compiled 86 yds, which had them averaging 3.7 yards per attempt.

If you look at scoring touchdowns, the Tennessee Titans are averaging 17.0 points per game. Offensively, they're holding an average of 88.7 rush yards which ranks them at 28th in the NFL. The Titans have amassed 667 yards for this campaign. Tennessee has a total of 26 first downs as a team, and they have been flagged for 31 penalties for 261 total yards. They have surrendered the ball 4 different times (1 interception and 3 lost fumbles). If you look at getting in the endzone, Tennessee has recorded 2 passing touchdowns and 1 rushing touchdown.

When examining passing yds, the Titans have relinquished 684 yds, putting them 22nd in the NFL. They have surrendered 228.0 total yards per game through the air, and are allowing a completion% of 67.3%. In total, they have allowed 437 running yards through 3 outings for the season. They have given up 4 touchdowns by way of the pass, in addition to 6 touchdowns by way of the ground game. On the whole, they are giving up 373.7 yards per contest, which is 27th in the league. The opposition is running for 5.3 yds per run and 145.7 rushing yds per game so far this year. The Titans currently rank 30th in pro football when examining their defensive abilities, surrendering 31.3 points per game.

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The Texans step onto the field with a record of 0-3 over the course of this season. In their last contest, the Texans took a loss by a final score of 17-10 when they faced the Jacksonville Jaguars. C.J. Stroud (1 touchdown) finished the game with 204 yards on 25-38 through the air while his quarterback rating was 66.1. He threw 2 picks and his average yds per pass attempt was 5.4 yds. Nico Collins was the best receiver for the Texans, grabbing 8 balls for 104 yds (13.0 yds per catch). Nick Chubb carried the football 9 times for 38 yards, walking away from the game with 4.2 yds per carry for Houston. The Texans ended up finishing with 271 yds and they ran 57 plays (4.8 yds per play). Houston rushed the football for 4.6 yards per attempt, totaling 87 yards on 19 carries. Houston relinquished 24 run attempts for 86 yards (3.6 yards per carry). The Texans passing defense conceded a completion percentage of 50.0%, surrendering 205 yds on 20 for 40 through the air.

Regarding the points being put on the board, the Texans are ranked 32nd in pro football, by tallying 12.7 PPG. On the season, the Texans have racked up 517 pass yards and hold an average of 172.3 pass yards per outing, which is good for 26th in professional football. They have an average of 95.0 rush yards per outing, and have toted the ball for 285 yards. The Houston Texans maintain an average of 267.3 total yards per contest, which ranks them at 29th in the NFL. The Houston offense has conceded 191 yards by way of 24 penalty flags, which is 14th in the league when you look at making mistakes. They have tossed 3 picks while yielding 2 lost fumbles, and have been able to obtain 22 first downs as a team.

They have surrendered 3 touchdowns by way of the pass in addition to 206.7 yards via the pass per outing, which has them sitting 13th in the league. Houston has granted a total of 327 rush yards (109.0 yards per outing), and 4 touchdowns to runners for this campaign. The D has a total of 2 turnovers (1 fumble and 1 interception) over the course of the season. Overall, they have surrendered 51 total points. The Texans defense has taken part in 195 plays from the line of scrimmage, putting them 25th in the NFL. The Texans are yielding 17.0 points per contest, which is good for 7th in professional football.

Who will win tonight's Titans-Texans NFL game against the spread?

Josh's Pick: Take the Titans +7

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