Tennessee Titans vs San Francisco 49ers Prediction, 12/14/2025 NFL Picks, Best Bets & Odds Week 15

Game: Tennessee Titans vs San Francisco 49ers

Date: Sunday, December 14, 2025

Location: Levi's Stadium in Santa Clara, CA

TV: FOX

Odds-Point Spread: 49ers (-12.5)

Total-Over-Under: 44.5

The Tennessee Titans (2-11) are on their way to Levi's Stadium on Sunday where they will attempt to beat the San Francisco 49ers (9-4). Tennessee opens this matchup as 12.5-point dogs from oddsmakers. The betting total comes in at 44.5.

The Tennessee Titans step on the gridiron holding a record of 2-11 over the course of the season. In their last game, the Titans faced the Cleveland Browns and walked away with a win by a score of 31-29. Cam Ward went 14-28 with 117 yards passing and 2 touchdowns. He had a quarterback rate of 70.1 and walked away from the game with 1 pick. Chimere Dike left with an average of 4.8 yds per catch by totaling 24 yds on 5 receptions. Tony Pollard was the best rusher for the Titans with 25 totes for 161 yards (6.4 yards per attempt). In all, they ran 63 plays which converted into 292 yards. The Tennessee Titans ended up running the ball 35 times and tallied 184 yds, which earned them an average of 5.3 yards per carry. On the ground, the Titans gave up 61 yards on 20 tries, which calculates to 3.1 yards per run allowed. Tennessee allowed 23 completions on 42 tries for 351 yards, and a completion rate of 54.8%.

When talking about scoring, the AFC South members are averaging 15.5 points per outing. As a team, they hold an average of 84.9 rushing yds which has them ranked 31st in football. The Titans have compiled 3,201 yds on the season. Tennessee has recorded 120 1st downs as a team, and they have been hurt by 101 infractions for 770 yards. They have given the ball to the opposition 17 times (7 interceptions and 10 lost fumbles). If you analyze scoring points, Tennessee has tallied 9 passing touchdowns and 6 touchdowns on the ground.

The Titans sit 29th in professional football concerning their defensive prowess, conceding 27.5 points per contest. They are allowing an average of 4.5 yds per rushing attempt and 122.5 rush yds per game over the course of this year. When analyzing pass yds, the Titans have conceded 2,970 yards, which ranks them 23rd in the league. They have yielded 228.5 total yards per outing via the pass, and are relinquishing a completion% of 67.6%. All in all, they are granting 350.9 yds per contest, giving them a rank of 26th in pro football. They have allowed 22 touchdowns through the air, and 18 touchdowns by way of the ground game. All in all, they have allowed 1,592 yards on the ground through 13 matchups on the year.

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The 49ers head into this matchup 9-4 for this campaign. The last time they stepped on the football field, the 49ers walked away with a victory by a final of 26-8 when they faced the Cleveland Browns. Brock Purdy (1 TD) finished the contest with 168 yards on 16-29 through the air while his quarterback rate was 83.7. He didn't throw any interceptions and his average yds per pass attempt was 5.8 yards. George Kittle was the leading receiver for the 49ers, bringing in 4 passes for 67 yards (16.8 yds per reception). Christian McCaffrey ran the ball 20 times for 53 yds, finishing the game with 2.7 yards per carry for San Francisco. The 49ers finished the game with 252 yds while running 63 plays (4.0 yards per play). San Francisco ended up running for 2.8 yds per carry, finishing the game with 91 yards on 33 carries. San Francisco allowed 31 running attempts for 138 yds (4.5 yds per carry). The 49ers passing defense gave up a completion rate of 65.4%, surrendering 115 yards on 17 for 26 through the air.

The San Francisco 49ers average 341.2 yards per outing, which ranks them 12th in the NFL. They average 98.5 rushing yards per contest, and have rushed for 1,281 yards. They have allowed 13 INTs while allowing 5 fumbles, and have been able to record 174 1st downs. The San Francisco offense has relinquished 499 yds on 67 penalty flags, which ranks them 31st in the NFL if you examine giving up free yards. For the season, the 49ers have compiled 3,154 passing yards and average 242.6 passing yards per contest, giving them a rank of 6th in pro football. Regarding their scoring prowess, the 49ers are 16th in the NFL, by tallying 23.6 points per outing.

They have relinquished 23 touchdowns through the air as well as 232.0 yards through the air per game, which has them ranked 25th in professional football. San Francisco has conceded a total of 1,349 rushing yards (103.8 yards per contest), plus 8 touchdowns by way of the ground game this year. The D has collected 14 turnovers (9 forced fumbles and 5 INTs) for this campaign. On the whole, they have surrendered 269 total points. The 49ers defense has taken the field for 790 plays from the line of scrimmage, which has them ranked 12th in football. The 49ers are giving up 20.7 PPG, which ranks them 8th in the NFL.

Who will win tonight's Titans-49ers NFL game against the spread?

Tony's Pick: Take the Titans +12.5

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