Washington Commanders vs Los Angeles Chargers Prediction, 10/5/2025 NFL Picks, Best Bets & Odds Week 5

Game: Washington Commanders vs Los Angeles Chargers

Date: Sunday, October 5, 2025

Location: SoFi Stadium in Inglewood, CA

TV: FOX

Odds-Point Spread: Chargers (-2.5)

Total-Over-Under: 48

The Washington Commanders (2-2) are en route to SoFi Stadium on Sunday where they will take on the Los Angeles Chargers (3-1). Los Angeles opens this matchup as 2.5-point favorites. The betting total is set at 48.

The Washington Commanders come into this game holding a record of 2-2 for this campaign. In their last contest, the Commanders stepped onto the field against the Atlanta Falcons and took a loss by a final of 34-27. Jacory Croskey-Merritt led the offense in rushing for the Commanders with 7 carries for 47 yds (6.7 yards per carry). Deebo Samuel had an average of 12.0 yds per reception by totaling 72 yds on 6 catches. Marcus Mariota finished 16-27 with 156 yards through the air and 2 touchdowns. He had a QB rating of 84.8 and walked away from the contest with 1 pick. Against the rush, the Commanders gave up 128 yards on 37 tries, which is 3.5 yards per rush allowed. Washington surrendered 20 pass completions on 26 tries for a total of 307 yds, and a completion percentage of 76.9%. Once the final whistle blew, they ran 49 plays for 294 yds. The Washington Commanders ended up running the ball 22 times and totaled 147 yds, which earned them an average of 6.7 yds per carry.

If you're looking at scoring points, the Washington Commanders hold an average of 26.8 points per outing. Offensively, they're holding an average of 154.8 rushing yds which is good for 2nd in professional football. The Commanders have tallied 1,356 total yards on the season. Washington has compiled 36 first downs as an offense, and they have been flagged for 30 penalties for 223 total yards. They have given the ball to the opposition 2 different times (1 interception and 1 fumble). If you're looking at scoring points, Washington has amassed 6 touchdowns through the air and 5 rushing touchdowns.

The Commanders are sitting 18th in football when it comes to their defensive abilities, granting 22.8 points per outing. They are allowing 3.6 yds per rush and 107.5 rushing yards per contest for the season. When examining yards through the air, the Commanders have granted 994 total yards, which is good for 27th in professional football. They have granted 248.5 total yards per contest via the pass, and are relinquishing a completion% of 61.0%. Overall, they are relinquishing 356.0 total yards per contest, which is good for 24th in professional football. They have relinquished 7 touchdowns via the pass, and 3 touchdowns via the ground game. All in all, they have granted 430 running yards through 4 contests on the season.

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The Chargers step onto the field with a record of 3-1 for this campaign. When they last took the field, the Chargers walked away with a loss by a score of 21-18 when they faced the New York Giants. Omarion Hampton ran the ball 12 times for 128 yards, ending the contest with 10.7 yards per carry for Los Angeles. Quentin Johnston was the best receiver for the Chargers, hauling in 8 throws for 98 yards (12.3 yards per catch). Justin Herbert (1 touchdown) finished the game with 203 yds on 23-41 passing while his quarterback rate was 57.3. He had 2 interceptions and his Y-A was 5.0 yards. Los Angeles conceded 42 run attempts for 161 yards (3.8 yards per rush). The Chargers passing defense gave up a completion percentage of 66.7%, surrendering 89 yds on 14 out of 21 through the air. The Chargers finished the game with 338 yds on 54 plays (6.3 yds per play). Los Angeles ran for 11.7 yards per carry, finishing with 152 yards on 13 attempts.

In terms of how much they score, the Chargers rank 20th in professional football, holding an average of 22.0 points per outing. For the season, the Chargers have a total of 996 yards through the air and hold an average of 249.0 yards through the air per game, which is 5th in football. They average 107.3 rush yds per contest, and have carried the football for 429 total yards. The Los Angeles Chargers average 356.3 total yards per game, which is good for 8th in professional football. The Los Angeles offense has yielded 214 yards by way of 29 penalties, which is 18th in football with reference to giving up free yards. They have allowed 3 interceptions while yielding 2 fumbles, and have recorded 49 first downs as an offense.

They have conceded 3 touchdowns through the air as well as 158.8 yards through the air per contest, putting them 5th in the league. Los Angeles has surrendered a total of 445 rushing yds (111.3 total yards per game), in addition to 3 touchdowns via the rush for the year. The D has recorded 3 turnovers for this campaign. Overall, they have given up 71 total points. The Chargers defense has been on the field for 240 plays from scrimmage, which is 13th in football. The Chargers are allowing 17.8 points per outing, putting them 4th in the NFL.

Who will win tonight's Commanders-Chargers NFL game against the spread?

Josh's Pick: Take the Chargers -2.5

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