Arizona Cardinals vs Los Angeles Chargers Prediction, 9/13/2026 NFL Picks, Best Bets & Odds Week 1

Game: Arizona Cardinals vs Los Angeles Chargers

Date: Sunday, September 13, 2026

Location: SoFi Stadium in Inglewood, CA

TV: CBS

Odds-Point Spread: Chargers -10.5

Total-Over-Under: 46.5

The Los Angeles Chargers (11-6 last season) host the Arizona Cardinals (3-14 last year) at SoFi Stadium on Sunday. Arizona opens as 10.5-point underdogs. The total has been set at 46.5.

The Arizona Cardinals concluded the season having a 3-14 mark. In their last game, the Cardinals faced the Los Angeles Rams and took a loss by a score of 37-20. Jacoby Brissett went 22-31 with 243 yds through the air and 2 touchdowns. He had a QB rate of 101.9 and ended the game with 1 pick. Michael Wilson left with an average of 19.8 yards per reception by recording 99 yds on 5 catches. Emari Demercado led the offense in rushing for the Cardinals with 2 totes for 29 yards (14.5 yds per attempt). In all, they ran 47 plays which gave them a total of 317 yds. The Arizona Cardinals ended up running the ball 15 times and accounted for 79 yds, which is an average of 5.3 yds per carry. When it came to stopping the run, the Cardinals gave up 143 yards on 31 tries, which is an average of 4.6 yds per run allowed. Arizona conceded 25 completions on 40 attempts for a total of 252 yards, and a completion rate of 62.5%.

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If you examine getting the ball in the endzone, the Cardinals held an average of 20.9 points per outing. As a team, they sat at 93.1 rushing yds, which had them ranking 31st in pro football. The Cardinals compiled 5,538 yds for last year. Arizona had a total of 216 1st downs as a unit, and they were hurt by 115 penalties for 842 yds. They surrendered the ball 21 different times (11 INTs and 10 lost fumbles). Arizona earned 29 passing touchdowns and 9 TD's via the ground game.

If you're looking at passing yards, the Cardinals allowed 3,923 total yards which had them ranking 24th in professional football. They surrendered 230.8 total yards per contest through the air, and gave up a completion% of 65.6%. Altogether, they surrendered 2,158 yards on the ground through 17 outings last season. They conceded 31 TD's through the air, along with 19 by way of the ground game. In total, they granted 357.7 per contest, which ranked them at 27th in pro football. They gave up 4.4 yds per rushing attempt and 126.9 rushing yds per contest last season. The Cardinals sat 29th in football when talking about their opponents scoring, allowing 28.7 PPG.

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The Chargers wrapped up their season having produced a 11-6 mark. The last time they took the field, the Chargers went home defeated by a final of 16-3 against the New England Patriots. Justin Herbert carried the rock 10 times for 57 yards, ending the contest with 5.7 yds per attempt for Los Angeles. Ladd McConkey was one of the featured targets for the Chargers, hauling in 3 balls for 32 yards (10.7 yards per reception). Justin Herbert ended the contest with 159 yards on 19-31 through the air while his QB rate was 74.5. He didn't throw any picks and his Y-A was 5.1 yards. Los Angeles surrendered 29 rushing attempts for 146 yds (5.0 yds per carry). The Chargers pass defense gave up a completion percentage of 56.7%, relinquishing 235 yards on 17 for 30 through the air. The Chargers finished the game with a total of 207 yds and they ran 53 plays (3.9 yards per play). Los Angeles rushed the ball for 4.0 yds per attempt, finishing the game with 87 yds on 22 attempts.

When talking about the points being put on the board, the Chargers sat 20th in football, averaging 21.6 points per game. Last season, the Chargers had a previous total of 3,608 yards via the pass and held an average of 212.2 yards via the pass per game, which was 18th in football. They held an average of 121.6 rushing yards per contest, and carried the ball for 2,067 yards. The Los Angeles Chargers held an average of 333.8 yards per contest, which ranked them at 12th in pro football. The Los Angeles offense surrendered 787 yards by way of 104 penalties, which had them ranked 21st in the NFL when examining helping out the opposition. They yielded 14 INTs while surrendering 7 fumbles, and accrued 185 first downs.

The Chargers allowed 20.0 points per game, which ranked them at 9th in pro football. They allowed 16 touchdowns through the air along with 179.9 pass yards per outing, which ranked them 5th in professional football. Los Angeles conceded a total of 1,791 running yards (105.4 total yards per contest), and 16 touchdowns on the ground for last season. The Chargers defense was on the field for 966 plays from the line of scrimmage, which ranked them at 2nd in pro football. The D accrued 23 takeaways (4 forced fumbles and 19 picks) for last year. On the whole, they allowed 340 total points.

Who will win tonight's Cardinals-Chargers NFL game against the spread?

Guy's Pick: Take the Chargers -10.5

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