Arizona Cardinals vs Los Angeles Rams Prediction, 10/18/2026 NFL Picks, Best Bets & Odds Week 6

Game: Arizona Cardinals vs Los Angeles Rams

Date: Sunday, October 18, 2026

Location: SoFi Stadium in Inglewood, CA

TV: FOX

Odds-Point Spread: Rams -13.5

Total-Over-Under: 52

The Arizona Cardinals (1-4) are headed to SoFi Stadium on Sunday where they will take on the Los Angeles Rams (2-3). Los Angeles is 13.5-point favorites from Vegas oddsmakers. The betting total is set at 52.

The Arizona Cardinals step onto the field holding a record of 1-4 over the course of this season. In their last contest, the Cardinals stepped onto the field against the Detroit Lions and ended up losing by a score of 45-21. Jeremiyah Love led the offense in rushing for the Cardinals with 12 attempts for 22 yards (1.8 yds per attempt). Kendrick Bourne had an average of 14.0 yds per catch by tallying 70 yds on 5 receptions. Jacoby Brissett connected on 29-47 with 292 yards passing and 3 TDs. He had a QB rate of 91.8 and walked away from the game with 1 interception. On the ground, the Cardinals gave up 163 yards on 32 attempts, which is an average of 5.1 yds per rush allowed. Arizona allowed 19 pass completions on 30 attempts for 249 yds, and a completion rate of 63.3%. In all, they tallied 66 plays which gave them 327 yards. The Arizona Cardinals ended up running the ball 18 different times and amassed 56 yds, earning them an average of 3.1 yards per carry.

If you analyze putting the ball in the endzone, the Cardinals have an average of 21.6 points per contest. As a team, they hold an average of 91.6 rushing yards which ranks 23rd in football. The Cardinals have produced 1,506 yards for the season. Arizona has a total of 64 first downs, and they have been called for 36 penalties for 345 yards. They have turned the football over 5 times. If you look at getting the ball into the endzone, Arizona has recorded 9 touchdowns via the pass and 3 ground TD's.

When examining passing yards, the Cardinals have given up 1,184 yds, which ranks them 25th in professional football. They have relinquished 236.8 total yards per contest through the air, and are giving up a completion% of 63.3%. Altogether, they have given up 633 yards via the ground game in 5 matchups over the course of this season. They have yielded 14 touchdowns by way of the pass, along with 6 touchdowns on the ground. All in all, they are yielding 363.4 total yards per contest, ranking this team at 26th in football. They are allowing 4.4 yds per running attempt and 126.6 rush yards per game over the course of this season. The Cardinals are ranked 32nd in football in terms of opponents scoring, yielding 32.4 points per outing.

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The Rams head into this matchup 2-3 over the course of this year. In their last contest, the Rams walked away with a loss by a score of 37-34 when they faced the Buffalo Bills. Kyren Williams carried the football 16 times for 49 yds, ending the game with 3.1 yds per carry for Los Angeles. Puka Nacua was the leading receiver for the Rams, snagging 17 footballs for 138 yards (8.1 yards per reception). Matthew Stafford (3 touchdowns) walked away from the contest with 383 yards on 40-54 through the air while his QB rating was 111.9. He didn't throw any picks and his average yards per pass attempt was 7.1 yds. Los Angeles surrendered 37 running attempts for 234 yards (6.3 yds per rush). The Rams passing defense allowed a completion rate of 63.2%, surrendering 202 yds on 12 out of 19 through the air. The Rams finished the contest with 454 yds while they ran 77 plays (5.9 yds per play). Los Angeles ran the ball for 3.3 yards per attempt, finishing the contest with 77 yards on 23 carries.

With reference to putting points on the board, the Rams are sitting 15th in football, by scoring 23.8 points per contest. In this campaign, the Rams have earned 1,538 passing yards and hold an average of 307.6 passing yards per game, which ranks them 1st in professional football. They have an average of 116.8 rush yds per contest, and have rushed for 584 yards. The Los Angeles Rams maintain an average of 424.4 total yards per game, which ranks 1st in football. The Los Angeles offense has conceded 368 yds on 42 penalties, giving them a rank of 7th in football when you look at helping out the other team. They have recorded 6 interceptions while giving up 2 fumbles, and have been able to record 79 1st downs offensively.

The Rams are giving up 24.0 points per contest, which ranks them 20th in the NFL. They have yielded 8 touchdowns via the pass as well as 156.8 passing yards per outing, which ranks them at 2nd in pro football. Los Angeles has surrendered a total of 642 rush yards (128.4 yards per contest), as well as 4 touchdowns via the ground game over the course of this season. The Rams defense has participated in 294 plays, ranking this team at 8th in football. The defense has compiled 5 turnovers (1 fumble and 4 interceptions) on the year. Altogether, they have yielded 120 total points.

Who will win tonight's Cardinals-Rams NFL game against the spread?

Tony's Pick: Take the Rams -13.5

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