Denver Broncos vs Arizona Cardinals Prediction, 10/25/2026 NFL Picks, Best Bets & Odds Week 7

Game: Denver Broncos vs Arizona Cardinals

Date: Sunday, October 25, 2026

Location: State Farm Stadium in Glendale, AZ

TV: CBS

Odds-Point Spread: Cardinals +4.0

Total-Over-Under: 43.5

The Denver Broncos (4-2) are en route to State Farm Stadium on Sunday where they will try to beat the Arizona Cardinals (2-4). Arizona is 4-point dogs from Vegas oddsmakers. The over-under is set at 43.5.

The Denver Broncos head into this matchup 4-2 for the season. In their last game, the Broncos played the Seattle Seahawks and notched a win by a score of 17-14. Bo Nix went 17-27 with 107 yards passing. He had a quarterback rate of 71.1 and ended the contest with no picks. J.K. Dobbins was the rushing leader for the Broncos with 17 totes for 41 yards (2.4 yds per carry). RJ Harvey had an average of 10.3 yards per catch by recording 31 yards on 3 catches. The Denver Broncos ended up rushing 28 times and accounted for 74 yards, which had them averaging 2.6 yds per carry. When the final whistle blew, they had 55 plays which gave them a total of 168 yds. Denver relinquished 27 completions on 51 attempts for 240 yds, and a completion percentage of 52.9%. On the ground, the Broncos conceded 113 yds on 26 tries, which calculates to 4.3 yds per run allowed.

The Broncos have collected 1,513 yds for this campaign. Denver has collected 50 1st downs as an offense, and they have been called for 44 penalties for 269 yards. When examining notching touchdowns, Denver has accrued 6 touchdowns via the pass and 5 TD's via the ground game. They have surrendered the football 6 different times (3 INTs and 3 lost fumbles). Offensively, they are averaging 84.2 rushing yards which is 26th in professional football. When it comes to scoring points, the AFC members are averaging 19.0 points per game.

When it comes to pass yards, the Broncos have allowed 1,251 total yards, which is 14th in professional football. They have relinquished 208.5 total yards per contest via the pass, and are conceding a completion percentage of 56.5%. On the whole, they have allowed 839 yards via the ground game in 6 games so far this season. They have surrendered 7 touchdowns through the air, and 6 touchdowns by way of the ground game. In total, they are giving up 348.3 total yards per contest, which is 22nd in professional football. The opposition is running for an average of 4.7 yds per rush on the ground and 139.8 rushing yards per game for this campaign. The Broncos currently rank 10th in the league when you look at their defensive prowess, conceding 20.8 points per game.

Get all of our NFL Picks Against the Spread

The Cardinals come into this matchup holding a record of 2-4 for the year. The last time they stepped on the football field, the Cardinals got the win with a final of 18-16 when they played the Los Angeles Rams. Jacoby Brissett finished the contest with 218 yds on 24-35 passing while his QB rating was 73.3. He had 1 interception and his avg yards per attempt was 6.2 yards. Trey McBride was one of the featured targets for the Cardinals, hauling in 7 balls for 53 yds (7.6 yards per catch). Zonovan Knight carried the rock 15 times for 80 yds, finishing the game with 5.3 yards per attempt for Arizona. The Cardinals finished the game with a total of 338 yards while running 70 plays (4.8 yards per play). Arizona ran for 3.4 yds per carry, finishing with a total of 120 yds on 35 attempts. Arizona relinquished 20 attempts on the ground for 92 yards (4.6 yards per rush). The Cardinals secondary gave up a completion rate of 75.8%, relinquishing 194 yds on 25 for 33 passing.

When talking about the points being put on the board, the Cardinals currently sit 24th in football, scoring 21.0 points per contest. In this season, the Cardinals have thrown for a total of 1,266 passing yards and are sitting at 211.0 passing yards per game, which has them ranked 20th in football. They maintain an average of 96.3 rushing yards per contest, and have carried the football for 578 total yards. The Arizona Cardinals average 307.3 yards per contest, ranking them 23rd in football. The Arizona offense has surrendered 396 total yards by way of 41 infractions, ranking this team at 20th in pro football if you analyze helping out the other team. They have a total of 6 INTs while surrendering 0 lost fumbles, and have been able to earn 78 1st downs as a team.

The Cardinals are conceding 29.7 points per outing, which has them ranking 32nd in the NFL. They have allowed 16 touchdowns via the pass plus 229.7 pass yards per contest, which is 22nd in professional football. Arizona has surrendered a total of 725 rushing yards (120.8 total yards per contest), and 6 touchdowns on the ground for the season. The Cardinals defense has taken the field for 350 plays from the line of scrimmage, which ranks them 8th in the league. The D has produced 8 turnovers (5 fumbles forced and 3 interceptions) for this campaign. All in all, they have surrendered 178 total points.

Who will win tonight's Broncos-Cardinals NFL game against the spread?

Tony's Pick: Take the Cardinals +4.0

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get NFL picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.