Jacksonville Jaguars vs Denver Broncos Prediction, 9/20/2026 NFL Picks, Best Bets & Odds Week 2

Game: Jacksonville Jaguars vs Denver Broncos

Date: Sunday, September 20, 2026

Location: Empower Field at Mile High in Denver, CO

TV: CBS

Odds-Point Spread: Broncos -2.5

Total-Over-Under: 44

The Denver Broncos (0-1) welcome the Jacksonville Jaguars (1-0) at Empower Field at Mile High on Sunday. Denver is 2.5-point favorites. The total comes in at 44.

The Jacksonville Jaguars step on the gridiron 1-0 on the campaign. The last time they took the field, the Jaguars took the field against the Cleveland Browns and notched a win by a score of 34-10. Trevor Lawrence finished 18-23 with 245 yards passing and 4 TDs. He had a QB rate of 150.6 and finished the game without throwing a pick. Bhayshul Tuten was the best rusher for the Jaguars with 15 carries for 66 yards (4.4 yards per carry). Parker Washington left with an average of 16.6 yds per catch by tallying 83 yards on 5 receptions. The Jacksonville Jaguars ran the football 32 different times and accumulated 126 yards, earning them an average of 3.9 yards per attempt. For the game, they had 55 plays which gave them 360 yards. Jacksonville gave up 16 pass completions on 22 attempts for a total of 185 yds, and a completion rate of 72.7%. In the running game, the Jaguars gave up 87 yds on 22 attempts, which is an average of 4.0 yds per run surrendered.

If you analyze getting in the endzone, the Jacksonville Jaguars have an average of 34.0 PPG. As a unit, they are averaging 126.0 rush yards which has them ranked 11th in professional football. The Jaguars have accumulated 360 yards over the course of this year. Jacksonville has notched 13 first downs as an offense, and they have been called for 4 penalties for 25 yards. They have yet to turn the ball over. When examining getting the ball in the endzone, Jacksonville has a total of 4 passing touchdowns.

When talking about pass yards, the Jaguars have allowed 185 yds, which is 13th in pro football. They have allowed 185.0 total yards per game through the air, and are surrendering a completion percentage of 72.7%. Altogether, they have relinquished 87 yards via the running game in 1 game over the course of the season. They have surrendered 1 touchdown by way of the pass. Altogether, they are relinquishing 272.0 total yards per contest, which is good for 10th in the league. They are allowing teams to run for an average of 4.0 yards per rushing attempt and 87.0 rush yards per outing over the course of the season. The Jaguars are ranked 4th in the league if you analyze their defensive prowess, relinquishing 10.0 PPG.

Get all of our NFL Picks Against the Spread

The Broncos step on the gridiron with a record of 0-1 over the course of this year. When they last took the field, the Broncos took a loss by a final score of 31-10 against the Kansas City Chiefs. J.K. Dobbins ran the football 8 times for 36 yards, ending the contest with 4.5 yards per carry for Denver. Pat Bryant was featured in the passing game for the Broncos, bringing in 4 balls for 42 yards (10.5 yards per catch). Bo Nix (1 touchdown) ended the contest with 131 yards on 17-28 through the air while his QB rate was 69.2. He threw 1 interception and his average yds per pass attempt was 4.7 yds. Denver relinquished 38 rush attempts for 220 yards (5.8 yds per carry). The Broncos pass defense gave up a completion percentage of 55.6%, relinquishing 172 yds on 15 for 27 through the air. The Broncos finished the contest with a total of 176 yards and they ran 43 plays (4.1 yards per play). Denver rushed the football for 4.1 yards per tote, finishing with 61 yards on 15 attempts.

If you look at the points being put on the board, the Broncos are ranked 30th in the league, with 10.0 points per outing. So far this year, the Broncos have thrown for 115 passing yds. They hold an average of 61.0 rushing yds per contest. The Denver Broncos have an average of 176.0 yards per outing, which has them ranked 32nd in professional football. The Denver offense has yielded 52 yds on 7 penalty flags, ranking them 22nd in pro football if you're looking at hurting your team. They have allowed 1 interception while giving up 1 fumble, and have tallied 6 1st downs as a unit.

The Broncos are surrendering 31.0 PPG, ranking this team at 24th in the NFL. They have allowed 2 touchdowns via the pass along with 172.0 pass yds per contest, which ranks 10th in pro football. Denver has surrendered a total of 220 rush yards. The Broncos defense has been on the field for 67 plays, which is 26th in pro football. The defense has a total of 1 turnover this season. Altogether, they have allowed 31 pts.

Who will win tonight's Jaguars-Broncos NFL game against the spread?

Tony's Pick: Take the Broncos -2.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get NFL picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.