Los Angeles Rams vs Arizona Cardinals Prediction, 11/15/2026 NFL Picks, Best Bets & Odds Week 10

Game: Los Angeles Rams vs Arizona Cardinals

Date: Sunday, November 15, 2026

Location: State Farm Stadium in Glendale, AZ

TV: CBS

Odds-Point Spread: Rams -9.0

Total-Over-Under: 39.5

State Farm Stadium is the place where the Arizona Cardinals (3-6) will try to beat the Los Angeles Rams (5-4) on Sunday. Los Angeles opens as 9-point favorites from Vegas oddsmakers. The total is set at 39.5.

The Los Angeles Rams head into this game 5-4 on the season. When they last took the field, the Rams took the field against the Washington Commanders and notched a win by a score of 20-13. Matthew Stafford went 26-43 with 228 yds through the air and 1 TD. He had a QB rating of 72.6 and walked away from the game with 1 pick. Kyren Williams was the leader on the ground for the Rams with 15 attempts for 45 yards (3.0 yards per carry). Puka Nacua had an average of 10.7 yds per reception by accounting for 150 yards on 14 catches. The Los Angeles Rams ran the ball 29 different times and amassed 124 yards, which earned them an average of 4.3 yards per carry. In the game, they ran 72 plays for 343 yards. Los Angeles surrendered 24 completions on 35 tries for 253 yards, and a completion rate of 68.6%. When it came to stopping the run, the Rams gave up 60 yards on 19 attempts, which is 3.2 yards per run surrendered.

When you look at getting the ball into the endzone, the NFC members average 23.8 points per game. As a team, they are averaging 125.3 running yards ranking this team at 9th in the league. The Rams have collected 3,418 total yards for the year. Los Angeles has accumulated 122 1st downs as a unit, and they have been flagged for 71 infractions for 599 yards. They have given the ball to the opposition 14 times (9 picks and 5 fumbles lost). If you examine putting the ball in the endzone, Los Angeles has a total of 16 passing touchdowns and 11 touchdowns via the ground.

The Rams are ranked 8th in professional football if you look at their defensive prowess, relinquishing 20.1 points per game. They are giving up an average of 4.0 yards per running attempt and 103.8 running yards per game over the course of the season. If you examine pass yds, the Rams have surrendered 1,788 total yards, putting them 11th in pro football. They have relinquished 198.7 total yards per contest by way of the pass, and are conceding a completion percentage of 61.1%. Overall, they are surrendering 302.4 yards per contest, which ranks 6th in football. They have given up 11 touchdowns through the air, and 4 touchdowns via the rush. In total, they have allowed 934 rushing yards through 9 matchups so far this season.

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The Cardinals head into this matchup 3-6 for this campaign. In their last contest, the Cardinals took a loss by a final score of 17-3 when they faced the Seattle Seahawks. Gardner Minshew II finished the game with 166 yards on 21-30 through the air while his QB rating was 83.5. He didn't toss any picks and his Y-A was 5.5 yards. Tyler Allgeier carried the football 17 times for 46 yds, finishing the game with 2.7 yards per carry for Arizona. Trey McBride was one of the featured targets for the Cardinals, snagging 7 balls for 54 yds (7.7 yards per catch). Arizona ran for 2.8 yards per attempt, finishing the contest with 50 yds on 18 carries. The Cardinals finished with a total of 198 yds while running 48 plays (4.1 yards per play). The Cardinals pass defense gave up a completion rate of 67.9%, surrendering 175 yards on 19 out of 28 passing. Arizona allowed 33 attempts on the ground for 120 yds (3.6 yds per carry).

The Arizona Cardinals hold an average of 318.0 yards per contest, putting them 22nd in professional football. They maintain an average of 102.7 rushing yards per game, and have run for 924 total yards. They have recorded 7 picks while giving up 1 fumble, and have been able to obtain 110 1st downs offensively. The Arizona offense has granted 629 yards on 68 violations, which has them sitting 11th in the league when examining hurting your team. In this campaign, the Cardinals have compiled 1,938 pass yards and average 215.3 pass yards per contest, which is good for 18th in the NFL. When you look at how much they score, the Cardinals currently sit 26th in football, by tallying 19.8 points per game.

They have relinquished 19 touchdowns by way of the pass and 215.4 pass yards per contest, which is good for 13th in the NFL. Arizona has surrendered a total of 1,097 running yards (121.9 total yards per outing), in addition to 10 touchdowns via the ground game for this campaign. The defense has earned 8 turnovers (5 forced fumbles and 3 INTs) over the course of this season. In total, they have allowed 255 points. The Cardinals defense has been on the field for 539 plays from the line of scrimmage, which is good for 22nd in the league. The Cardinals are relinquishing 28.3 points per game, which is good for 31st in the NFL.

Who will win tonight's Rams-Cardinals NFL game against the spread?

Guy's Pick: Take the Rams -9.0

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