Los Angeles Rams vs Denver Broncos Prediction, 9/27/2026 NFL Picks, Best Bets & Odds Week 3

Game: Los Angeles Rams vs Denver Broncos

Date: Sunday, September 27, 2026

Location: Empower Field at Mile High in Denver, CO

TV: NBC

Odds-Point Spread: Rams -2.5

Total-Over-Under: 45

The Denver Broncos (1-1) will try to beat the Los Angeles Rams (1-1) at Empower Field at Mile High on Sunday. Los Angeles opens as 2.5-point favorites from oddsmakers. The betting total is set at 45.

The Los Angeles Rams step on the gridiron 1-1 so far this season. The last time they took the field, the Rams went up against the New York Giants and notched a win by a score of 28-6. Matthew Stafford went 22-31 with 327 yards passing and 4 touchdowns. He had a QB rating of 131.3 and finished the game with 1 interception. Kyren Williams was the rushing leader for the Rams with 12 totes for 85 yards (7.1 yards per carry). Davante Adams had an average of 24.4 yds per reception by notching 195 yds on 8 receptions. The Los Angeles Rams ended up rushing 28 times and totaled 163 yards, which came out to an average of 5.8 yards per attempt. In all, they had 59 plays which gave them a total of 481 yards. Los Angeles relinquished 14 completions on 32 tries for 130 yds, and a completion rate of 43.8%. When it came to stopping the run, the Rams conceded 52 yds on 21 attempts, which calculates to 2.5 yds per run allowed.

When examining putting the ball in the endzone, the NFC representatives have an average of 17.5 PPG. As a unit, they are averaging 142.5 running yards which is 6th in football. The Rams have collected 771 total yards so far this season. Los Angeles has accumulated 21 first downs as a team, and they have been called for 10 penalties for 93 total yards. They have turned the football over 4 different times (2 interceptions and 2 fumbles lost). When examining getting the ball in the endzone, Los Angeles has a total of 4 passing touchdowns and 1 rushing touchdown.

If you examine pass yds, the Rams have granted 335 yds, giving them a rank of 7th in football. They have granted 167.5 yards per game by way of the pass, and are granting a completion rate of 59.1%. Overall, they have given up 226 yards on the ground through 2 games over the course of the season. They have yielded 3 touchdowns by way of the pass. All in all, they are conceding 280.5 yards per game, which ranks 7th in the NFL. They are allowing 4.4 yds per running attempt and 113.0 running yds per contest over the course of this season. The Rams are ranking 8th in football if you examine the other team scoring points, yielding 16.5 PPG.

Get all of our NFL Picks

The Broncos come into this game with a record of 1-1 on the year. The last time they stepped on the gridiron, the Broncos took home the win by a final score of 20-13 when they faced the Jacksonville Jaguars. Bo Nix (1 TD) walked away from the game with 288 yards on 22-31 through the air while his quarterback rating was 97.2. He tossed 1 interception and his average yds per pass attempt was 9.3 yards. Jonah Coleman carried the rock 10 times for 39 yds, ending the game with 3.9 yds per carry for Denver. Jaylen Waddle was featured in the passing game for the Broncos, snagging 8 footballs for 138 yards (17.3 yds per catch). Denver ended up running for 3.7 yards per carry, finishing with 104 yards on 28 attempts. The Broncos finished the game with 392 yards on 59 plays (6.6 yards per play). The Broncos pass defense allowed a completion percentage of 58.6%, relinquishing 173 yds on 17 for 29 passing. Denver allowed 24 attempts on the ground for 95 yds (4.0 yards per carry).

The Denver Broncos maintain an average of 284.0 yards per game, which ranks 25th in the NFL. They maintain an average of 82.5 rush yds per game, and have carried the football for 165 yards. They have allowed 2 interceptions while conceding 1 fumble, and have been able to earn 19 1st downs as an offense. The Denver offense has allowed 105 total yards by way of 17 penalties, putting them 9th in the league if you examine making mistakes. For the season, the Broncos have compiled 403 pass yards and are averaging 201.5 pass yards per contest, which has them sitting 20th in football. If you examine the points being put on the board, the Broncos currently rank 28th in football, by tallying 15.0 points per outing.

The Broncos are giving up 22.0 points per contest, giving them a rank of 13th in the NFL. They have given up 2 touchdowns by way of the pass along with 172.5 pass yds per outing, which is 8th in football. Denver has yielded a total of 315 rushing yards (157.5 total yards per contest), as well as 3 touchdowns to runners over the course of this season. The Broncos defense has taken the field for 122 plays from the line of scrimmage, which is 20th in football. Their defense has a total of 2 turnovers (0 fumbles forced and 2 INTs) so far this year. All in all, they have granted 44 pts.

Who will win tonight's Rams-Broncos NFL game against the spread?

Josh's Pick: Take the Rams -2.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get NFL picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.