New York Giants vs Los Angeles Rams Prediction, 9/21/2026 NFL Picks, Best Bets & Odds Week 2

Game: New York Giants vs Los Angeles Rams

Date: Monday, September 21, 2026

Location: SoFi Stadium in Inglewood, CA

TV: ESPN

Odds-Point Spread: Rams -7.5

Total-Over-Under: 48

SoFi Stadium is the site where the Los Angeles Rams (0-1) will compete against the New York Giants (1-0) on Monday. Los Angeles opens this contest as 7.5-point favorites. The betting total comes in at 48.

The New York Giants come into this game holding a record of 1-0 so far this season. In their last game, the Giants played the Dallas Cowboys and earned the victory with a final of 28-20. Cam Skattebo was the leader on the ground for the Giants with 18 totes for 81 yards (4.5 yards per carry). Isaiah Likely had an average of 9.8 yds per catch by totaling 78 yards on 8 receptions. Jaxson Dart connected on 23-29 with 230 yards passing and 3 touchdowns. He had a quarterback rating of 134.2 and walked away from the game without throwing a pick. In the running game, the Giants conceded 69 yards on 18 attempts, which averages out to 3.8 yds per run allowed. New York relinquished 22 completions on 34 tries for 175 yds, and a completion rate of 64.7%. At the end of the game, they had 66 plays which converted into 394 yards. The New York Giants ran the ball a total of 37 times and accounted for 165 yds, which had them averaging 4.5 yds per attempt.

The Giants have accumulated 394 yards over the course of this year. New York has tallied 14 1st downs as a unit, and they have been flagged for 10 infractions for 114 total yards. If you look at scoring touchdowns, New York has collected 3 touchdowns through the air and 1 rushing touchdown. They have given the ball to the opposition 1 time. As a team, they are sitting at 165.0 running yards which is 6th in pro football. Concerning putting points on the board, the NFC East representatives are sitting at 28.0 points per game.

The Giants are ranked 11th in the league when it comes to team defense, allowing 20.0 points per outing. They are allowing an average of 3.8 yards per tote and 69.0 rushing yards per outing on the campaign. If you examine passing yds, the Giants have surrendered 175 yds, ranking them 11th in pro football. They have relinquished 175.0 yards per outing by way of the pass, and are giving up a completion% of 64.7%. Overall, they are allowing 244.0 yards per outing, putting them 5th in pro football. They have granted 2 touchdowns through the air, along with 1 touchdown by way of the ground game. Altogether, they have allowed 69 yards via the ground game in 1 game for the season.

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The Rams come into this game with a record of 0-1 over the course of this year. When they last took the field, the Rams went home defeated by a final of 27-7 against the San Francisco 49ers. Matthew Stafford walked away from the contest with 155 yds on 15-25 passing while his QB rating was 61.2. He threw 1 interception and his avg yards per attempt was 6.2 yards. Kyren Williams carried the rock 11 times for 41 yds, ending the game with 3.7 yards per carry for Los Angeles. Puka Nacua was one of the featured targets for the Rams, hauling in 5 throws for 74 yards (14.8 yds per catch). Los Angeles ran the ball for 4.2 yards per carry, finishing the game with 122 yards on 29 carries. The Rams finished the contest with a total of 290 yards and they ran 57 plays (5.1 yds per play). The Rams pass defense allowed a completion rate of 73.5%, surrendering 205 yds on 25 out of 34 through the air. Los Angeles allowed 30 rush attempts for 174 yds (5.8 yds per rush).

If you're looking at the points being put on the board, the Rams rank 32nd in professional football, averaging 7.0 points per contest. For the season, the Rams have thrown for 168 passing yds. They have an average of 122.0 running yds per outing. The Los Angeles Rams average 290.0 yds per outing, ranking them 19th in pro football. The Los Angeles offense has yielded 43 total yards by way of 4 penalties, ranking this team at 30th in the NFL when you look at helping out the other team. They have allowed 1 interception while relinquishing 1 fumble, and have been able to obtain 6 1st downs.

The Rams are giving up 27.0 points per contest, which is 19th in pro football. They have given up 3 touchdowns through the air along with 205.0 pass yards per contest, which ranks them at 19th in the league. Los Angeles has conceded a total of 174 running yards. The Rams defense has participated in 64 plays from scrimmage, giving them a rank of 20th in professional football. Their defense has compiled 1 turnover on the season. All in all, they have relinquished 27 pts.

Who will win tonight's Giants-Rams NFL game against the spread?

Tony's Pick: Take the Rams -7.5

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