Pittsburgh Steelers vs New England Patriots Prediction, 9/20/2026 NFL Picks, Best Bets & Odds Week 2

Game: Pittsburgh Steelers vs New England Patriots

Date: Sunday, September 20, 2026

Location: Gillette Stadium in Foxborough, MA

TV: CBS

Odds-Point Spread: Steelers +5.5

Total-Over-Under: 41.5

The Pittsburgh Steelers (1-0) are headed to Gillette Stadium on Sunday where they will take on the New England Patriots (0-1). Pittsburgh opens this contest as 5.5-point dogs from Vegas oddsmakers. The total comes in at 41.5.

The Pittsburgh Steelers step on the gridiron 1-0 on the campaign. The last time they stepped on the football field, the Steelers played against the Atlanta Falcons and earned the victory with a final of 20-13. Jaylen Warren was the leader on the ground for the Steelers with 10 attempts for 46 yds (4.6 yards per attempt). Pat Freiermuth had an average of 9.2 yards per reception by accumulating 46 yds on 5 receptions. Aaron Rodgers connected on 24-40 with 221 yards passing and 1 touchdown. He had a quarterback rating of 83.4 and walked away from the game without throwing a pick. On the ground, the Steelers conceded 120 yds on 31 attempts, which is 3.9 yds per run allowed. Pittsburgh gave up 12 pass completions on 22 attempts for a total of 118 yds, and a completion percentage of 54.5%. In the game, they ran 62 plays which gave them a total of 264 yards. The Pittsburgh Steelers ran the ball 21 times and totaled 58 yds, which earned them an average of 2.8 yards per attempt.

When talking about scoring, the AFC representatives hold an average of 20.0 points per outing. Collectively, they're averaging 58.0 rushing yards giving them a rank of 32nd in professional football. The Steelers have collected 264 yds for the season. Pittsburgh has tallied 10 1st downs as a unit, and they have been flagged for 7 infractions for 52 total yards. They have given the ball to the opposition 1 time. When examining getting the ball into the endzone, Pittsburgh has compiled 1 passing touchdown.

The Steelers currently sit 7th in the NFL when you look at their defensive prowess, allowing 13.0 PPG. They are giving up 3.9 yards per attempt on the ground and 120.0 rush yards per contest over the course of this year. When talking about pass yards, the Steelers have conceded 118 yards, putting them 2nd in pro football. They have allowed 118.0 yds per contest via the pass, and are giving up a completion% of 54.5%. All in all, they are giving up 238.0 yards per outing, giving them a rank of 3rd in professional football. They have granted 1 touchdown via the pass. Altogether, they have conceded 120 running yards through 1 game for this campaign.

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The Patriots head into this matchup 0-1 for the season. When they last took the field, the Patriots walked away with a loss by a score of 13-10 when they played the Seattle Seahawks. Rhamondre Stevenson ran the ball 18 times for 51 yards, finishing the contest with 2.8 yards per carry for New England. DeMario Douglas was featured in the passing game for the Patriots, snagging 5 balls for 20 yards (4.0 yds per reception). Drake Maye (1 touchdown) finished the game with 178 yds on 23-33 through the air while his quarterback rating was 54.9. He threw 3 picks and his average yards per pass attempt was 5.4 yards. New England surrendered 22 attempts on the ground for 97 yards (4.4 yds per carry). The Patriots secondary gave up a completion rate of 70.8%, surrendering 188 yds on 17 for 24 passing. The Patriots finished with 277 yds while running 64 plays (4.3 yards per play). New England ran for 3.5 yards per tote, finishing with 109 yards on 31 attempts.

The New England Patriots have an average of 277.0 yards per outing, which has them ranked 22nd in professional football. They have an average of 109.0 running yards per game. They have recorded 3 interceptions and have been able to earn 9 1st downs as an offense. The New England offense has surrendered 50 yds on 7 penalty flags, which is 21st in pro football if you look at making mistakes. For the year, the Patriots have thrown for a total of 168 pass yds. When talking about their scoring prowess, the Patriots currently sit 28th in pro football, with 10.0 points per contest.

The Patriots are conceding 13.0 points per outing, which ranks them at 8th in the league. They have relinquished 1 touchdown via the pass in addition to 188.0 pass yds per outing, which has them ranking 16th in professional football. New England has yielded a total of 97 rush yds. The Patriots defense has participated in 48 plays, ranking this team at 2nd in the NFL. The defense has no takeaways. Altogether, they have conceded 13 total points.

Who will win tonight's Steelers-Patriots NFL game against the spread?

Guy's Pick: Take the Steelers +5.5

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