San Francisco 49ers vs Philadelphia Eagles Prediction, 1/11/2026 NFL Picks, Best Bets & Odds

Game: San Francisco 49ers vs Philadelphia Eagles

Date: Sunday, January 11, 2026

Location: Lincoln Financial Field in Philadelphia, PA

TV: FOX

Odds-Point Spread: Eagles (-4.5)

Total-Over-Under: 45

The San Francisco 49ers (12-5) are traveling to Lincoln Financial Field on Sunday where they will meet the Philadelphia Eagles (11-6) in an NFC Wild Card game. San Francisco opens this matchup as 4.5-point dogs from oddsmakers. The betting total comes in at 45.

The San Francisco 49ers head into this game 12-5 on the campaign. The last time they stepped on the gridiron, the 49ers played against the Seattle Seahawks and took a loss by a final of 13-3. Brock Purdy finished 19-27 with 127 yds through the air. He had a quarterback rate of 64.9 and finished the game with 1 pick. Christian McCaffrey averaged 5.7 yards per reception by earning 34 yards on 6 receptions. Christian McCaffrey led the offense in rushing for the 49ers with 8 carries for 23 yds (2.9 yds per attempt). When all was said and done, they had 39 plays for 173 yards. The San Francisco 49ers ran the rock 12 different times and accrued 53 yds, which had them averaging 4.4 yds per attempt. When it came to the battle of the line of scrimmage, the 49ers gave up 180 yds on 39 attempts, which calculates to 4.6 yards per rush allowed. San Francisco surrendered 20 completions on 26 tries for a total of 181 yds, and a completion rate of 76.9%.

If you examine scoring, the 49ers average 25.7 points per contest. As a team, they're averaging 106.9 rushing yards which ranks them at 24th in the league. The 49ers have compiled 5,974 yards on the season. San Francisco has racked up 237 first downs, and they have been flagged for 83 infractions for 651 total yards. They have surrendered the ball 22 times (16 INTs and 6 fumbles lost). In terms of putting the ball in the endzone, San Francisco has amassed 33 touchdowns through the air and 15 touchdowns on the ground.

If you're looking at pass yds, the 49ers have allowed 3,951 total yards, which ranks 25th in football. They have conceded 232.4 yds per outing by way of the pass, and are allowing a completion rate of 68.2%. Overall, they have conceded 1,833 running yards through 17 contests on the campaign. They have allowed 29 touchdowns through the air, and 13 touchdowns to runners. All in all, they are allowing 340.2 total yards per outing, which ranks them at 20th in the league. They are allowing teams to run for an average of 4.3 yards per rush on the ground and 107.8 rushing yds per outing over the course of this year. The 49ers are ranking 13th in pro football with reference to the other team scoring points, yielding 21.8 points per outing.

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The Eagles step onto the field with a record of 11-6 for the year. In their last game, the Eagles took a loss by a final score of 24-17 when they faced the Washington Commanders. Tanner McKee (1 TD) ended the game with 241 yds on 21-40 through the air while his QB rate was 68.9. He tossed 1 pick and his Y-A was 6.0 yards. Tank Bigsby ran the ball 16 times for 75 yards, ending the contest with 4.7 yds per carry for Philadelphia. Kylen Granson was the leading receiver for the Eagles, snagging 4 balls for 30 yards (7.5 yards per catch). Philadelphia rushed the ball for 4.2 yards per tote, finishing the game with 80 yards on 19 carries. The Eagles finished the contest with 307 yds while running 59 plays (5.2 yards per play). The Eagles passing defense conceded a completion percentage of 63.6%, surrendering 131 yards on 14 out of 22 through the air. Philadelphia allowed 41 rush attempts for 143 yards (3.5 yds per rush).

The Philadelphia Eagles maintain an average of 311.2 yds per contest, which ranks 24th in the NFL. They maintain an average of 116.9 rushing yards per contest, and have toted the ball for 1,988 yds. They have compiled 7 picks while granting 8 lost fumbles, and have tallied 166 first downs. The Philadelphia offense has granted 1,073 total yards on 117 penalty flags, putting them 10th in professional football concerning giving up free yards. In this season, the Eagles have compiled 3,303 yards via the pass and have an average of 194.3 yards via the pass per outing, which is good for 23rd in professional football. If you examine their scoring prowess, the Eagles currently rank 19th in the league, maintaining an average of 22.3 PPG.

The Eagles are granting 19.1 points per contest, putting them 5th in professional football. They have allowed 14 touchdowns through the air and 189.8 passing yards per game, giving them a rank of 8th in pro football. Philadelphia has granted a total of 2,115 rushing yds (124.4 total yards per outing), and 20 touchdowns via the rush over the course of this year. The Eagles defense has taken the field for 1,080 plays from scrimmage, giving them a rank of 26th in pro football. The D has racked up 21 turnovers (9 fumbles forced and 12 picks) so far this year. All in all, they have given up 325 pts.

Who will win tonight's 49ers-Eagles NFL game against the spread?

Parlays Pundit's Pick: Take the Eagles -4.5 and over 45 total points

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