Seattle Seahawks vs Arizona Cardinals Prediction, 9/20/2026 NFL Picks, Best Bets & Odds Week 2

Game: Seattle Seahawks vs Arizona Cardinals

Date: Sunday, September 20, 2026

Location: State Farm Stadium in Glendale, AZ

TV: FOX

Odds-Point Spread: Seahawks -4.0

Total-Over-Under: 41

State Farm Stadium is the location where the Arizona Cardinals (1-0) will take on the Seattle Seahawks (1-0) on Sunday. Arizona opens as 4-point underdogs from oddsmakers. The betting total comes in at 41.

The Seattle Seahawks step on the gridiron 1-0 on the campaign. The last time they stepped on the gridiron, the Seahawks went up against the New England Patriots and went home with a win by a final score of 13-10. Drew Lock connected on 16-22 with 187 yds passing and 1 touchdown. He had a QB rating of 113.3 and ended the contest without throwing a pick. Jaxon Smith-Njigba held an average of 15.3 yards per reception by tallying 122 yds on 8 receptions. Jadarian Price was the rushing leader for the Seahawks with 10 totes for 52 yards (5.2 yds per attempt). On the day, they had 46 plays which totaled 285 yds. The Seattle Seahawks ran the rock 22 different times and totaled 97 yds, earning them an average of 4.4 yards per attempt. When it came to stopping the run, the Seahawks gave up 109 yds on 31 attempts, which is 3.5 yds per run surrendered. Seattle surrendered 23 completions on 33 attempts for a total of 168 yards, and a completion percentage of 69.7%.

The Seahawks have accumulated 285 yards over the course of this year. Seattle has recorded 9 first downs as a team, and they have been called for 10 infractions for 98 yards. When examining getting the ball into the endzone, Seattle has compiled 1 passing touchdown. They have yet to turn the ball over. As a team, they are sitting at 97.0 running yards which is 21st in pro football. Concerning putting points on the board, the Seahawks are sitting at 13.0 points per game.

The Seahawks are ranking 2nd in pro football if you're looking at opponents scoring, relinquishing 10.0 points per outing. They are giving up 3.5 yards per attempt on the ground and 109.0 rush yards per contest over the course of this year. When talking about pass yards, the Seahawks have conceded 168 yards, putting them 9th in pro football. They have surrendered 168.0 total yards per outing via the pass, and are allowing a completion percentage of 69.7%. Altogether, they are yielding 277.0 yds per contest, which is 11th in pro football. They have given up 1 touchdown through the air. Altogether, they have relinquished 109 yards via the running game in 1 game over the course of the season.

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The Cardinals come into this game with a record of 1-0 so far this season. The last time they stepped on the gridiron, the Cardinals walked away with a victory by a final of 26-14 when they played the Los Angeles Chargers. Jacoby Brissett (1 touchdown) ended the game with 277 yards on 27-37 through the air while his quarterback rate was 103.1. He didn't toss any picks and his average yards per pass attempt was 7.5 yds. Tyler Allgeier ran the football 17 times for 61 yards, finishing the contest with 3.6 yards per attempt for Arizona. Trey McBride had the best day in terms of receiving for the Cardinals, grabbing 9 footballs for 95 yds (10.6 yds per catch). Arizona ran the ball for 3.4 yards per tote, finishing the contest with 116 yds on 34 carries. The Cardinals ended up finishing with 393 yards and they ran 71 plays (5.5 yards per play). The Cardinals passing defense gave up a completion percentage of 63.0%, surrendering 187 yards on 17 out of 27 passing. Arizona allowed 21 rush attempts for 81 yards (3.9 yds per carry).

The Arizona Cardinals average 393.0 yds per contest, putting them 8th in professional football. They hold an average of 116.0 rushing yds per outing. They have been able to earn 15 1st downs as a unit. The Arizona offense has conceded 111 yards on 8 penalties, which is 13th in pro football if you look at making mistakes. Over the course of this season, the Cardinals have earned 277 passing yds. Concerning their ability to score points, the Cardinals are 16th in pro football, by tallying 26.0 points per contest.

The Cardinals are allowing 14.0 points per contest, putting them 9th in pro football. They have granted 1 touchdown by way of the pass as well as 187.0 pass yds per outing, which ranks them 15th in football. Arizona has conceded a total of 81 running yards. The Cardinals defense has participated in 51 plays from scrimmage, giving them a rank of 6th in professional football. The defense has a total of 2 takeaways (1 fumble and 1 interception) this season. Altogether, they have allowed 14 total points.

Who will win tonight's Seahawks-Cardinals NFL game against the spread?

Tony's Pick: Take the Seahawks -4.0

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