San Francisco 49ers vs Buffalo Bills Prediction, 12/1/2024 NFL Picks, Best Bets & Odds Week 13

Game: San Francisco 49ers at Buffalo Bills

Date: Sunday, December 1, 2024

Location: Highmark Stadium in Orchard Park, NY

TV: NBC

Odds/Point Spread: Bills (-6.0)

Total/Over-Under: 47

Highmark Stadium is the location where the Buffalo Bills (9-2) will try to defeat the San Francisco 49ers (5-6) on Sunday. San Francisco is 6.0-point dogs from oddsmakers. The total is set at 47.

The San Francisco 49ers come into this matchup with a record of 5-6 for this year. The last time they stepped on the gridiron, the 49ers played the Green Bay Packers and took a loss by a final of 38-10. Brandon Allen went 17/29 with 199 yards passing and 1 TD. He had a quarterback rating of 76.7 and walked away from the contest with 1 interception. George Kittle left with an average of 13.7 yds per catch by accumulating 82 yds on 6 catches. Christian McCaffrey led the offense in rushing for the 49ers with 11 attempts for 31 yards (2.8 yds per attempt). Once the final whistle blew, they tallied 45 plays which totaled 241 yards. The San Francisco 49ers ended up running the ball 16 different times and totaled 44 yds, earning them an average of 2.8 yds per attempt. On the ground, the 49ers gave up 169 yards on 42 tries, which is an average of 4.0 yds per run allowed. San Francisco surrendered 13 completions on 23 attempts for a total of 156 yards, and a completion rate of 56.5%.

Regarding scoring, the San Francisco 49ers are averaging 23.6 points per contest. Offensively they're maintaining an average of 138.4 yards in the run game which is 7th in the league. The 49ers have racked up 4,230 total yards over the course of this year. San Francisco has accumulated 129 1st downs as a team, and they have committed 69 penalties for 572 yards. They have given the ball to the opposition 16 times (9 interceptions and 7 fumbles lost). When it comes to getting the ball in the endzone, San Francisco has amassed 14 passing touchdowns and 10 touchdowns via the ground.

Regarding yards through the air, the 49ers have surrendered 2,128 yards which has them ranked 5th in the NFL. They have conceded 193.5 yards per contest through the air as well as allowing a completion percentage of 63.1%. They have surrendered 13 touchdowns via the pass as well as 16 touchdowns via the ground game. During the season, they have surrendered 304.3 yards per outing ranking them 6th in the NFL. They are giving up an average of 4.2 yards per rush and 110.8 rushing yards per contest for the season. The 49ers are ranked 20th in the league regarding the opposition scoring, allowing 23.6 PPG. During the season, they have allowed 1,219 running yards through 11 games.

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The Bills head into this matchup 9-2 this season. The last time they stepped on the gridiron, the Bills got the win with a final of 30-21 when they played the Kansas City Chiefs. Josh Allen carried the ball 12 times for 55 yards, finishing the contest with 4.6 yards per carry for Buffalo. Khalil Shakir was one of the featured targets for the Bills, snagging 8 footballs for 70 yards (8.8 yds per reception). Josh Allen (1 touchdown) walked away from the contest with 262 yds on 27/40 passing while his quarterback rating was 83.5. He threw 1 pick and his avg yards per attempt was 6.6 yards. Buffalo conceded 17 rushing attempts for 78 yards (4.6 yds per carry). The Bills passing defense allowed a completion percentage of 69.7%, surrendering 181 yards on 23 out of 33 passing. The Bills finished the game with a total of 366 yds and they ran 71 plays (5.2 yds per play). Buffalo rushed the ball for 3.4 yds per carry, finishing with a total of 104 yards on 31 attempts.

The Buffalo Bills average 345.3 yards/game ranking them 13th out of all teams in the league. They hold an average of 119.2 yards per game via the rush and have rushed for 1,311 yards in total. The Buffalo offense has racked up 517 yds of penalties on 68 violations, which has them sitting 20th in the league in terms of making mistakes. For the year to this point, the Bills have earned 2,487 yards through the air together with holding an average of 226.1 passing yards per contest, which has them ranked 13th in football. Regarding their scoring prowess, the Bills are ranked 3rd in football maintaining an average of 29.1 points per game.

The Bills are giving up 19.5 points per contest, which has them in 7th of all teams in the NFL. They have allowed 16 touchdowns through the air in addition to 210.0 yards/outing, ranking them 14th in the league. Buffalo has allowed the opposition a total of 1,310 rushing yards (119.1 yards/game) as well as 6 touchdowns on the ground this year. The Bills defense has participated in 670 plays, which is 13th in football. They have compiled 21 turnovers (8 fumbles and 13 picks) on the campaign.

Who will win tonight's 49ers/Bills NFL game against the spread?

Josh's Pick: Take the 49ers +6.0

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