Atlanta Falcons vs Carolina Panthers Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3

Game: Atlanta Falcons vs Carolina Panthers

Date: Sunday, September 21, 2025

Location: Bank of America Stadium in Charlotte, NC

TV: FOX

Odds-Point Spread: Panthers (+5)

Total-Over-Under: 43.5

The Carolina Panthers (0-2) will compete against the Atlanta Falcons (1-1) at Bank of America Stadium on Sunday. Atlanta opens this contest as 5-point favorites from Vegas oddsmakers. The total comes in at 43.5.

The Atlanta Falcons step on the gridiron holding a record of 1-1 so far this season. When they last stepped on the football field, the Falcons played the Minnesota Vikings and took home the win by a score of 22-6. Michael Penix went 13-21 with 135 yards through the air. He had a QB rate of 80.5 and finished the game with no picks. Bijan Robinson was the best rusher for the Falcons with 22 carries for 143 yards (6.5 yards per carry). Drake London had an average of 16.3 yds per catch by accounting for 49 yards on 3 receptions. The Atlanta Falcons ended up running the ball 39 different times and accounted for 218 yds, which came out to an average of 5.6 yards per carry. When all was said and done, they ran 60 plays which totaled 326 yds. Atlanta gave up 11 completions on 21 attempts for a total of 120 yards, and a completion rate of 52.4%. Against the run, the Falcons conceded 78 yards on 19 attempts, which is an average of 4.1 yards per rush allowed.

The Falcons have racked up 684 total yards this season. Atlanta currently has 21 first downs as a team, and they have been called for 13 penalties for 84 yds. When it comes to getting in the endzone, Atlanta has produced 1 passing touchdown and 2 TD's on the ground. They have given the ball away 1 time. As a unit, they're sitting at 143.5 rush yards ranking them 4th in the league. When analyzing getting the ball into the endzone, the Atlanta Falcons average 21.0 points per outing.

The Falcons are 2nd in pro football if you examine their defensive prowess, yielding 14.5 points per outing. The opposition is running for 4.3 yards per rushing attempt and 89.5 running yds per game on the season. If you analyze yards via the pass, the Falcons have surrendered 279 yards, ranking them 2nd in football. They have allowed 139.5 yds per contest via the pass, and are conceding a completion rate of 52.8%. In total, they are giving up 229.0 yds per contest, ranking them 2nd in the league. They have yielded 3 touchdowns by way of the pass. On the whole, they have allowed 179 rushing yards through 2 contests on the season.

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The Panthers step on the gridiron with a record of 0-2 over the course of the season. In their last game, the Panthers took a loss by a score of 27-22 when they faced the Arizona Cardinals. Bryce Young (3 touchdowns) ended the game with 328 yds on 35-55 through the air while his quarterback rating was 90.6. He threw 1 interception and his avg yards per attempt was 6.0 yds. Tetairoa McMillan was the best receiver for the Panthers, hauling in 6 passes for 100 yds (16.7 yds per reception). Chuba Hubbard carried the ball 10 times for 38 yds, ending the game with 3.8 yds per carry for Carolina. The Panthers finished the contest with 352 yards while they ran 74 plays (4.8 yards per play). Carolina rushed for 2.6 yards per attempt, finishing with a total of 49 yards on 19 attempts. Carolina allowed 22 rushing attempts for 82 yards (3.7 yards per rush). The Panthers secondary conceded a completion rate of 68.0%, relinquishing 211 yds on 17 for 25 passing.

The Carolina Panthers have an average of 303.5 yds per contest, ranking them 22nd in the league. They maintain an average of 81.0 running yds per outing, and have carried the football for 162 yds. They have recorded 27 1st downs. The Carolina offense has granted 118 yds by way of 11 penalties, which is good for 28th in professional football when analyzing helping out the other team. This year, the Panthers have compiled 445 pass yds and hold an average of 222.5 pass yds per contest, ranking them 13th in the league. When examining the points being put on the board, the Panthers currently sit 29th in football, with an average of 16.0 PPG.

The Panthers are yielding 26.5 PPG, which is good for 24th in professional football. They have yielded 2 touchdowns via the pass in addition to 194.5 pass yards per contest, which is 11th in professional football. Carolina has conceded a total of 282 rushing yds (141.0 yds per outing), as well as 2 touchdowns via the ground game this year. The Panthers defense has participated in 111 plays, which has them ranked 7th in the NFL. Their defense currently has 2 takeaways. Overall, they have allowed 53 points.

Who will win tonight's Falcons-Panthers NFL game against the spread?

Josh's Pick: Take the Falcons -5

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