Atlanta Falcons vs San Francisco 49ers Prediction, 10/19/2025 NFL Picks, Best Bets & Odds Week 7

Game: Atlanta Falcons vs San Francisco 49ers

Date: Sunday, October 19, 2025

Location: Levi's Stadium in Santa Clara, CA

TV: NBC

Odds-Point Spread: 49ers (-2)

Total-Over-Under: 47.5

The San Francisco 49ers (4-2) will try to defeat the Atlanta Falcons (3-2) at Levi's Stadium on Sunday. Atlanta opens this contest as 2-point underdogs. The total is 47.5.

The Atlanta Falcons step on the gridiron 3-2 on the year. The last time they stepped on the gridiron, the Falcons played against the Buffalo Bills and went home with a win by a final score of 24-14. Michael Penix finished 20-32 with 250 yds passing and 1 TD. He had a quarterback rate of 97.1 and walked away from the contest without throwing an interception. Bijan Robinson led the offense in rushing for the Falcons with 19 attempts for 170 yards (8.9 yards per attempt). Drake London had an average of 15.8 yds per catch by tallying 158 yds on 10 receptions. The Atlanta Falcons ran the football 32 times and compiled 210 yards, earning them an average of 6.6 yds per attempt. On the day, they ran 64 plays which totaled 443 yards. Atlanta conceded 15 pass completions on 26 tries for 157 yds, and a completion rate of 57.7%. When it came to the battle of the line of scrimmage, the Falcons conceded 134 yards on 24 attempts, which is 5.6 yds per rush surrendered.

When examining getting in the endzone, the NFC members average 20.0 PPG. As a unit, they maintain an average of 151.2 rushing yds which ranks 1st in the league. The Falcons have amassed 1,894 yards so far this season. Atlanta has accumulated 56 first downs, and they have been called for 27 infractions for 187 yards. They have surrendered the ball 5 different times (3 INTs and 2 fumbles). If you look at putting points on the board, Atlanta has earned 4 touchdowns via the pass and 6 rushing TD's.

With reference to passing yds, the Falcons have surrendered 697 yds, ranking them 1st in football. They have conceded 139.4 yards per contest via the pass, and are surrendering a completion rate of 57.7%. On the whole, they have yielded 570 running yards through 5 contests over the course of this season. They have granted 7 touchdowns through the air, and 2 touchdowns to rushers. Overall, they are surrendering 253.4 yds per outing, which is good for 1st in football. They are giving up 4.8 yards per running attempt and 114.0 rushing yds per game over the course of the season. The Falcons sit 7th in the league if you examine team defense, allowing 20.0 points per game.

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The 49ers step onto the field with a record of 4-2 on the campaign. The last time they stepped on the gridiron, the 49ers went home defeated by a final of 30-19 against the Tampa Bay Buccaneers. Mac Jones walked away from the game with 347 yards on 27-39 passing while his quarterback rate was 75.5. He tossed 2 interceptions and his average yards per pass attempt was 8.9 yds. Christian McCaffrey was featured in the passing game for the 49ers, snagging 7 passes for 57 yds (8.1 yds per reception). Christian McCaffrey ran the football 17 times for 54 yards, finishing the contest with 3.2 yards per attempt for San Francisco. The 49ers finished the contest with 363 yards while running 61 plays (6.0 yards per play). San Francisco ran for 3.0 yds per carry, finishing with a total of 67 yards on 22 attempts. San Francisco gave up 26 rushing attempts for 104 yards (4.0 yards per carry). The 49ers passing defense allowed a completion rate of 73.9%, surrendering 248 yards on 17 for 23 through the air.

The San Francisco 49ers have an average of 373.7 yards per contest, which has them sitting 6th in the league. They maintain an average of 82.2 rushing yds per contest, and have carried the football for 493 total yards. They have tossed 7 interceptions while yielding 3 fumbles, and have obtained 90 first downs as a unit. The San Francisco offense has yielded 333 yards by way of 41 violations, which has them sitting 19th in the league when it comes to hurting your team. This season, the 49ers have a total of 1,749 pass yards and have an average of 291.5 pass yards per game, which ranks 1st in the league. When examining their ability to score points, the 49ers are ranked 24th in the NFL, averaging 20.8 PPG.

The 49ers are allowing 21.3 points per contest, ranking them 15th in pro football. They have granted 10 touchdowns through the air and 214.3 yards through the air per outing, ranking them 18th in the NFL. San Francisco has relinquished a total of 644 rushing yds (107.3 yards per game), plus 4 touchdowns via the rush so far this year. The 49ers defense has taken part in 358 plays from scrimmage, ranking them 16th in football. Their defense has recorded 5 turnovers this season. Overall, they have granted 128 pts.

Who will win tonight's Falcons-49ers NFL game against the spread?

Tony's Pick: Take the Falcons +2

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