Buffalo Bills vs New York Jets Prediction, 9/14/2025 NFL Picks, Best Bets & Odds Week 2

Game: Buffalo Bills vs New York Jets

Date: Sunday, September 14, 2025

Location: MetLife Stadium in East Rutherford, NJ

TV: CBS

Odds-Point Spread: Jets (+6.5)

Total-Over-Under: 46

The Buffalo Bills (1-0) are on their way to MetLife Stadium on Sunday where they will try to defeat the New York Jets (0-1). Buffalo opens this game as 6.5-point favorites. The over-under has been set at 46.

The Buffalo Bills step onto the field holding a record of 1-0 for this campaign. In their last game, the Bills faced off with the Baltimore Ravens and earned the victory with a final of 41-40. Josh Allen went 33-46 with 394 yards passing and 2 touchdowns. He had a QB rate of 112 and ended the contest with no interceptions. Keon Coleman had an average of 14.0 yards per catch by totaling 112 yards on 8 receptions. Josh Allen was the leader on the ground for the Bills with 14 attempts for 30 yds (2.1 yards per carry). For the game, they ran 77 plays which totaled 497 yds. The Buffalo Bills ended up running the ball 31 times and tallied 108 yards, earning them an average of 3.5 yards per tote. Against the run, the Bills gave up 238 yds on 29 attempts, which calculates to 8.2 yards per run allowed. Buffalo allowed 14 pass completions on 19 attempts for 194 yds, and a completion rate of 73.7%.

The Bills have recorded 497 yards over the course of this season. Buffalo has a total of 18 first downs as an offense, and they have been called for 5 infractions for 38 yards. When examining scoring, Buffalo has earned 2 passing TD's and 3 ground TD's. They have yet to turn the ball over. As a unit, they hold an average of 108.0 rushing yds which ranks them 15th in the NFL. If you analyze scoring touchdowns, the AFC East members average 41.0 points per game.

If you're looking at pass yards, the Bills have surrendered 194 yds, putting them 16th in pro football. They are granting a completion rate of 73.7%. They have given up 2 touchdowns via the pass, as well as 3 touchdowns to runners. On the whole, they are yielding 432.0 total yards per game, ranking them 31st in pro football. They are allowing an average of 8.2 yards per run and 238.0 rushing yards per game for the year. The Bills currently sit 31st in the league when it comes to the opposition scoring, relinquishing 40.0 points per game.

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The Jets come into this game with a record of 0-1 over the course of the season. In their last game, the Jets took a loss by a score of 34-32 when they played the Pittsburgh Steelers. Justin Fields (1 touchdown) finished the contest with 218 yards on 16-22 passing while his QB rating was 119.1. He didn't toss any picks and his average yds per pass attempt was 9.9 yds. Garrett Wilson was a featured target for the Jets, hauling in 7 footballs for 95 yds (13.6 yards per catch). Breece Hall carried the ball 19 times for 107 yds, ending the game with 5.6 yds per carry for New York. The Jets finished the game with 394 yards and they ran 61 plays (6.5 yds per play). New York ended up running for 4.7 yards per carry, finishing with a total of 182 yds on 39 attempts. New York gave up 20 run attempts for 53 yds (2.7 yards per rush). The Jets pass defense allowed a completion rate of 73.3%, relinquishing 218 yards on 22 out of 30 through the air.

When examining their ability to score points, the Jets are 5th in the NFL, by tallying 32.0 points per outing. In this campaign, the Jets have thrown for 212 yards through the air ranking them 12th in professional football. They have toted the ball for 182 yards. The New York Jets have an average of 394.0 yds per outing, which ranks them 5th in the NFL. The New York offense has granted 74 yards on 7 violations, which is 16th in professional football if you're looking at helping out the opposition.

They have yielded 4 touchdowns via the pass as well as 218.0 yards through the air per outing, which has them ranking 22nd in the league. New York has surrendered a total of 53 rushing yds. Their defense has yet to take the ball away. The Jets defense has been on the field for 54 plays from scrimmage, which ranks 7th in professional football. The Jets are conceding 34.0 points per game, putting them 30th in pro football.

Who will win tonight's Bills-Jets NFL game against the spread?

Guy's Pick: Take the Jets +6.5

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