Denver Broncos vs Indianapolis Colts Prediction, 9/14/2025 NFL Picks, Best Bets & Odds Week 2

Game: Denver Broncos vs Indianapolis Colts

Date: Sunday, September 14, 2025

Location: Lucas Oil Stadium in Indianapolis, IN

TV: CBS

Odds-Point Spread: Colts (+2.5)

Total-Over-Under: 42

The Indianapolis Colts (1-0) welcome the Denver Broncos (1-0) at Lucas Oil Stadium on Sunday. Denver opens this game as 2.5-point favorites from oddsmakers. The over-under has been set at 42.

The Denver Broncos step onto the field holding a record of 1-0 for this campaign. The last time they stepped on the football field, the Broncos played against the Tennessee Titans and earned the victory with a final of 20-12. J.K. Dobbins led the offense in rushing for the Broncos with 16 carries for 63 yards (3.9 yards per attempt). Courtland Sutton averaged 10.2 yards per catch by earning 61 yds on 6 receptions. Bo Nix went 25-40 with 176 yds through the air and 1 touchdown. He had a QB rate of 60 and ended the game with 2 interceptions. Against the run, the Broncos gave up 71 yards on 21 tries, which is 3.4 yards per rush allowed. Denver surrendered 12 pass completions on 28 attempts for a total of 62 yards, and a completion rate of 42.9%. Once the final whistle blew, they ran 70 plays which converted into 317 yds. The Denver Broncos ran the ball 30 times and compiled 151 yards, which had them averaging 5.0 yds per attempt.

The Broncos have earned 317 yds on the campaign. Denver has compiled 9 1st downs as a team, and they have committed 6 infractions for 45 yards. When examining getting in the endzone, Denver has a total of 1 passing touchdown and 1 rushing touchdown. They have turned the ball over 4 different times. Collectively, they're maintaining an average of 151.0 rush yards ranking them 7th in the NFL. If you look at putting the ball in the endzone, the Denver Broncos are sitting at 20.0 points per game.

When examining pass yds, the Broncos have conceded 62 yds, ranking them 1st in the NFL. They are granting a completion% of 42.9%. They haven't given up a touchdown. On the whole, they are relinquishing 133.0 yds per outing, which ranks them 1st in the NFL. They are giving up an average of 3.4 yds per running attempt and 71.0 rushing yds per contest on the year. The Broncos currently sit 5th in pro football in terms of their defensive abilities, conceding 12.0 PPG.

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The Colts come into this game with a record of 1-0 over the course of the season. When they last took the field, the Colts walked away with a victory by a final of 33-8 when they played the Miami Dolphins. Daniel Jones (1 TD) ended the game with 272 yards on 22-29 passing while his quarterback rate was 115.9. He didn't toss any interceptions and his Y-A was 9.4 yds. Tyler Warren was the best receiver for the Colts, snagging 7 footballs for 76 yards (10.9 yds per catch). Jonathan Taylor ran the ball 18 times for 71 yds, finishing the game with 3.9 yards per attempt for Indianapolis. The Colts finished the game with a total of 418 yards and they ran 69 plays (6.1 yds per play). Indianapolis ended up running for 3.9 yds per carry, finishing the contest with 156 yards on 40 carries. Indianapolis allowed 12 running attempts for 78 yds (6.5 yds per carry). The Colts secondary allowed a completion percentage of 61.3%, surrendering 133 yds on 19 for 31 through the air.

The Indianapolis Colts have an average of 418.0 yds per outing, which ranks them 4th in the NFL. They have carried the football for 156 total yards. The Indianapolis offense has yielded 45 yards on 4 penalties, which ranks 27th in professional football if you're looking at helping out the opposition. In this campaign, the Colts have thrown for 262 yards through the air ranking them 8th in professional football. When examining their ability to score points, the Colts are 4th in the NFL, by tallying 33.0 points per outing.

The Colts are yielding 8.0 points per game, ranking them 2nd in pro football. They have conceded 1 touchdown via the pass along with 133.0 passing yds per contest, which is 4th in professional football. Indianapolis has granted a total of 78 rush yards. The Colts defense has taken the field for 46 plays from the line of scrimmage, ranking them 1st in pro football. The D has accumulated 3 takeaways.

Who will win tonight's Broncos-Colts NFL game against the spread?

Guy's Pick: Take the Broncos -2.5

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