Denver Broncos vs Los Angeles Chargers Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3

Game: Denver Broncos vs Los Angeles Chargers

Date: Sunday, September 21, 2025

Location: SoFi Stadium in Inglewood, CA

TV: CBS

Odds-Point Spread: Chargers (-2.5)

Total-Over-Under: 46

SoFi Stadium is the location where the Los Angeles Chargers (2-0) will try to beat the Denver Broncos (1-1) on Sunday. Los Angeles opens this game as 2.5-point favorites from Vegas oddsmakers. The total is 46.

The Denver Broncos head into this matchup 1-1 on the season. In their last game, the Broncos stepped onto the field against the Indianapolis Colts and took a loss by a score of 29-28. J.K. Dobbins was the rushing leader for the Broncos with 14 totes for 76 yds (5.4 yds per carry). Troy Franklin held an average of 11.1 yds per reception by accounting for 89 yards on 8 catches. Bo Nix went 22-30 with 206 yards passing and 3 touchdowns. He had a quarterback rate of 111.2 and finished the game with 1 pick. On the ground, the Broncos gave up 167 yds on 32 attempts, which is an average of 5.2 yards per rush surrendered. Denver relinquished 23 pass completions on 34 tries for 306 yards, and a completion percentage of 67.6%. When the final whistle blew, they tallied 54 plays which gave them a total of 324 yds. The Denver Broncos ended up running the ball 24 times and amassed 118 yds, which had them averaging 4.9 yards per attempt.

The Broncos have notched 641 yds for the year. Denver currently has 20 first downs as a team, and they have been hurt by 14 infractions for 128 yards. When analyzing getting the ball into the endzone, Denver has accrued 4 touchdowns through the air and 2 touchdowns via the ground. They have given the ball to the opposition 5 times (3 interceptions and 2 lost fumbles). Offensively, they're maintaining an average of 134.5 rushing yds ranking them 10th in the NFL. When it comes to getting in the endzone, the Broncos are sitting at 24.0 points per outing.

When examining pass yds, the Broncos have relinquished 368 yards, which is good for 9th in football. They have conceded 184.0 total yards per outing by way of the pass, and are giving up a completion percentage of 56.5%. On the whole, they have surrendered 238 yards via the ground game in 2 contests this season. They have allowed 1 touchdown via the pass, and 1 touchdown via the ground game. Overall, they are allowing 303.0 yds per outing, which has them sitting 12th in the league. The opposition is running for an average of 4.5 yards per rush and 119.0 rushing yds per outing this year. The Broncos are ranked 14th in football concerning their opponents scoring, yielding 20.5 PPG.

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The Chargers step on the gridiron with a record of 2-0 so far this season. The last time they stepped on the gridiron, the Chargers got the win with a final of 20-9 when they faced the Las Vegas Raiders. Justin Herbert (2 TDs) ended the contest with 242 yards on 19-27 through the air while his quarterback rate was 122.8. He kept the ball away from the defense with no picks and his average yds per pass attempt was 9.0 yds. Quentin Johnston had the best day in terms of receiving for the Chargers, catching 3 balls for 71 yds (23.7 yds per reception). Justin Herbert ran the ball 9 times for 31 yards, ending the contest with 3.4 yards per attempt for Los Angeles. The Chargers finished the game with 317 yds and they ran 53 plays (6.0 yds per play). Los Angeles ran for 3.1 yards per attempt, totaling 81 yds on 26 carries. Los Angeles conceded 19 rush attempts for 68 yards (3.6 yds per rush). The Chargers pass defense allowed a completion rate of 55.8%, relinquishing 150 yards on 24 for 43 through the air.

The Los Angeles Chargers average 355.5 yards per game, which is good for 9th in football. They hold an average of 85.5 rushing yds per outing, and have run for 171 yds. They have tallied 24 1st downs as an offense. The Los Angeles offense has allowed 82 yards by way of 12 violations, ranking them 23rd in the NFL if you examine helping out the opposition. This year, the Chargers sit at 540 pass yards and hold an average of 270.0 pass yards per contest, ranking them 4th in the NFL. When you look at the points being put on the board, the Chargers are ranking 13th in the league, with an average of 23.5 points per game.

The Chargers are conceding 15.0 PPG, ranking them 3rd in football. They have allowed 1 touchdown via the pass in addition to 199.5 pass yards per game, which is good for 16th in professional football. Los Angeles has relinquished a total of 166 rushing yds (83.0 yards per game), in addition to 1 touchdown via the ground game so far this season. The Chargers defense has taken the field for 123 plays from the line of scrimmage, which is good for 15th in professional football. The defense has attained 3 takeaways. On the whole, they have allowed 30 points.

Who will win tonight's Broncos-Chargers NFL game against the spread?

Guy's Pick: Take the Broncos +2.5

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