Detroit Lions vs Baltimore Ravens Prediction, 9/22/2025 NFL Picks, Best Bets & Odds Week 3

Game: Detroit Lions vs Baltimore Ravens

Date: Monday, September 22, 2025

Location: M&T Bank Stadium in Baltimore, MD

TV: ESPN

Odds-Point Spread: Ravens (-5.5)

Total-Over-Under: 51.5

The Detroit Lions (1-1) are on their way to M&T Bank Stadium on Monday where they will try to defeat the Baltimore Ravens (1-1). Baltimore is 5.5-point favorites. The total comes in at 51.5.

The Detroit Lions come into this game holding a record of 1-1 over the course of this year. In their last contest, the Lions played against the Chicago Bears and went home with a win by a final score of 52-21. Jared Goff went 23-28 with 334 yds passing and 5 TDs. He had a quarterback rating of 156 and finished the game with no picks. Jahmyr Gibbs was the rushing leader for the Lions with 12 totes for 94 yds (7.8 yds per attempt). Amon-Ra St. Brown averaged 12.8 yards per reception by totaling 115 yards on 9 catches. The Detroit Lions ended up running the ball 30 different times and amassed 177 yds, which came out to an average of 5.9 yards per attempt. For the game, they tallied 58 plays for 511 yards. Detroit gave up 21 completions on 33 attempts for a total of 205 yards, and a completion rate of 63.6%. Against the rush, the Lions gave up 134 yards on 27 attempts, which calculates to 5.0 yds per rush allowed.

When talking about getting in the endzone, the Detroit Lions average 32.5 PPG. As a unit, they are sitting at 111.5 rushing yds which has them sitting 15th in the league. The Lions have produced 757 yds for the season. Detroit currently has 28 first downs as a team, and they have been called for 10 penalties for 68 yds. They have turned the ball over 1 time. If you examine scoring, Detroit currently has 6 touchdowns via the pass and 2 TD's on the ground.

The Lions are 21st in pro football if you examine their defensive prowess, yielding 24.0 points per outing. The opposition is running for 4.1 yards per rushing attempt and 106.0 running yds per game on the season. When it comes to yards through the air, the Lions have conceded 393 total yards, which has them ranked 12th in the NFL. They have conceded 196.5 total yards per outing by way of the pass, and are giving up a completion percentage of 67.3%. In total, they are giving up 302.5 yds per contest, ranking them 11th in the league. They have surrendered 4 touchdowns through the air, plus 2 touchdowns by way of the ground game. In total, they have surrendered 212 yards via the ground game in 2 matchups so far this season.

Get all of our NFL Picks Against the Spread

The Ravens step on the gridiron with a record of 1-1 so far this season. The last time they took the field, the Ravens got the victory with a final of 41-17 against the Cleveland Browns. Lamar Jackson (4 touchdowns) ended the game with 225 yards on 19-29 through the air while his quarterback rate was 128.6. He didn't toss any picks and his avg yards per attempt was 7.8 yds. Derrick Henry ran the ball 11 times for 23 yards, walking away from the game with 2.1 yds per attempt for Baltimore. Zay Flowers was the leading receiver for the Ravens, bringing in 7 footballs for 75 yds (10.7 yards per catch). Baltimore ran for 2.1 yards per attempt, finishing the game with 45 yds on 21 attempts. The Ravens finished the game with a total of 242 yds while running 50 plays (4.8 yards per play). The Ravens passing defense conceded a completion percentage of 58.3%, surrendering 207 yds on 28 for 48 passing. Baltimore surrendered 22 running attempts for 115 yards (5.2 yards per rush).

The Baltimore Ravens have an average of 337.0 total yards per outing, which has them ranked 11th in the NFL. They have an average of 141.5 running yds per outing, and have carried the football for 283 total yards. They have recorded 18 1st downs. The Baltimore offense has relinquished 79 yards on 13 violations, ranking them 19th in football concerning making mistakes. So far this season, the Ravens have a total of 391 pass yds and average 195.5 pass yds per game, which is good for 23rd in football. When talking about putting points on the board, the Ravens are ranking 1st in professional football, holding an average of 40.5 PPG.

The Ravens are giving up 29.0 points per contest, ranking them 25th in the NFL. They have allowed 4 touchdowns by way of the pass along with 298.0 pass yards per contest, ranking them 31st in the NFL. Baltimore has granted a total of 223 running yds (111.5 yds per game), in addition to 3 touchdowns to runners on the season. The Ravens defense has taken the field for 150 plays from the line of scrimmage, which is good for 32nd in professional football. Their defense has collected 2 takeaways. Overall, they have granted 58 points in total.

Who will win tonight's Lions-Ravens NFL game against the spread?

Tony's Pick: Take the Ravens -5.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here