Green Bay Packers vs Arizona Cardinals Prediction, 10/19/2025 NFL Picks, Best Bets & Odds Week 7
Game: Green Bay Packers vs Arizona Cardinals
Date: Sunday, October 19, 2025
Location: State Farm Stadium in Glendale, AZ
TV: FOX
Odds-Point Spread: Cardinals (+6.5)
Total-Over-Under: 44.5
State Farm Stadium is the place where the Arizona Cardinals (2-4) will attempt to beat the Green Bay Packers (3-1) on Sunday. Green Bay is 6.5-point favorites. The betting total comes in at 44.5.
The Green Bay Packers head into this game 3-1 this season. In their last game, the Packers stepped onto the field against the Cincinnati Bengals and earned the victory with a final of 27-18. Jordan Love finished 19-26 with 259 yards through the air and 1 TD. He had a QB rate of 101.3 and finished the game with 1 interception. Josh Jacobs was the rushing leader for the Packers with 18 attempts for 93 yds (5.2 yds per attempt). Josh Jacobs had an average of 11.4 yds per catch by accumulating 57 yds on 5 catches. The Green Bay Packers ran the rock 33 times and accounted for 153 yards, which came out to an average of 4.6 yards per carry. When the final whistle blew, they ran 59 plays which gave them 409 yards. Green Bay surrendered 29 completions on 45 attempts for 213 yards, and a completion percentage of 64.4%. In the running game, the Packers conceded 55 yards on 16 tries, which calculates to 3.4 yards per run surrendered.

If you're looking at putting points on the board, the Green Bay Packers are sitting at 26.2 PPG. Offensively, they have an average of 122.2 rushing yards ranking them 12th in professional football. The Packers have accrued 1,798 yds on the campaign. Green Bay has produced 57 first downs, and they have been flagged for 40 infractions for 285 yds. They have turned the football over 3 times (2 interceptions and 1 fumble). If you analyze scoring, Green Bay has accrued 9 passing touchdowns and 6 TD's via the ground game.
If you're looking at pass yds, the Packers have yielded 1,036 total yards, which has them ranked 6th in professional football. They have granted 207.2 yards per contest through the air, and are yielding a completion percentage of 67.3%. All in all, they have relinquished 365 yards via the ground game in 5 games on the year. They have given up 8 touchdowns through the air, in addition to 3 touchdowns via the rush. On the whole, they are allowing 280.2 total yards per contest, which has them ranked 5th in professional football. They are allowing 3.6 yards per rush and 73.0 rushing yards per contest this season. The Packers are ranking 10th in the league when it comes to the opposition scoring, yielding 20.4 points per contest.
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The Cardinals come into this game with a record of 2-4 this year. The last time they stepped on the gridiron, the Cardinals took a defeat with a final score of 31-27 when they played the Indianapolis Colts. Michael Carter carried the rock 9 times for 34 yds, walking away from the contest with 3.8 yards per carry for Arizona. Trey McBride had the best day in terms of receiving for the Cardinals, bringing in 8 throws for 72 yards (9.0 yds per catch). Jacoby Brissett (2 TDs) finished the game with 320 yards on 27-44 through the air while his quarterback rate was 89.2. He had 1 pick and his average yards per pass attempt was 7.3 yds. Arizona gave up 27 running attempts for 150 yards (5.6 yds per carry). The Cardinals pass defense gave up a completion percentage of 73.3%, relinquishing 205 yds on 22 out of 30 passing. The Cardinals finished the game with 400 yds while running 68 plays (5.9 yds per play). Arizona ended up running for 3.7 yards per attempt, finishing the game with 88 yds on 24 attempts.
If you're looking at their ability to score points, the Cardinals are ranking 20th in professional football, averaging 21.7 PPG. On the season, the Cardinals sit at 1,163 pass yds and are averaging 193.8 pass yds per outing, ranking them 24th in pro football. They maintain an average of 113.2 rushing yds per game, and have carried the football for 679 yds. The Arizona Cardinals maintain an average of 307.0 yards per game, which ranks 22nd in the league. The Arizona offense has conceded 338 yards by way of 48 violations, ranking them 7th in pro football if you look at hurting your team. They have allowed 4 interceptions while giving up 3 fumbles lost, and have obtained 67 1st downs.
They have surrendered 7 touchdowns via the pass and 246.0 passing yds per outing, ranking them 28th in football. Arizona has granted a total of 612 rush yds (102.0 yards per outing), and 5 touchdowns to rushers this year. The D has amassed 7 takeaways on the campaign. All in all, they have relinquished 127 points. The Cardinals defense has participated in 395 plays, ranking them 28th in the NFL. The Cardinals are giving up 21.2 points per outing, which has them ranked 14th in football.
Who will win tonight's Packers-Cardinals NFL game against the spread?
Josh's Pick: Take the Cardinals +6.5
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Additional Resources:
Arizona Cardinals - Twitter
Green Bay Packers - Twitter