Houston Texans vs Jacksonville Jaguars Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3

Game: Houston Texans vs Jacksonville Jaguars

Date: Sunday, September 21, 2025

Location: EverBank Stadium in Jacksonville, FL

TV: CBS

Odds-Point Spread: Jaguars (-1)

Total-Over-Under: 44.5

The Houston Texans (0-2) are en route to EverBank Stadium on Sunday where they will meet the Jacksonville Jaguars (1-1). Jacksonville opens this contest as 1-point favorites from Vegas oddsmakers. The total comes in at 44.5.

The Houston Texans step on the gridiron 0-2 this year. When they last stepped on the football field, the Texans stepped onto the field against the Tampa Bay Buccaneers and walked away from this one with a loss by a score of 20-19. Nick Chubb was the best rusher for the Texans with 12 attempts for 43 yards (3.6 yds per carry). Nico Collins averaged 17.3 yds per reception by accumulating 52 yards on 3 receptions. C.J. Stroud connected on 13-24 with 207 yds passing and 1 touchdown. He had a QB rating of 97 and ended the contest without throwing an interception. Against the rush, the Texans conceded 169 yards on 30 attempts, which averages out to 5.6 yds per run surrendered. Houston surrendered 25 completions on 38 tries for 191 yds, and a completion rate of 65.8%. Overall, they ran 43 plays which gave them a total of 266 yds. The Houston Texans ended up running the ball 19 different times and amassed 84 yds, which came out to an average of 4.4 yards per tote.

Regarding getting in the endzone, the AFC South members average 14.0 points per contest. Offensively, they're maintaining an average of 99.0 running yds putting them 21st in pro football. The Texans have accrued 531 total yards so far this season. Houston has produced 14 1st downs, and they have been called for 17 penalties for 125 yards. They have surrendered the ball 2 different times (1 interception and 1 fumble). When examining scoring, Houston has accumulated 1 passing touchdown and 1 rushing touchdown.

When it comes to yards through the air, the Texans have conceded 415 total yards, which has them ranked 17th in the NFL. They have allowed 207.5 yds per outing through the air, and are surrendering a completion rate of 68.7%. Overall, they have conceded 241 yards via the ground game in 2 contests so far this season. They have yielded 3 touchdowns by way of the pass, as well as 2 touchdowns on the ground. All in all, they are giving up 328.0 yards per contest, ranking them 20th in the NFL. They are allowing teams to run for an average of 4.4 yards per rushing attempt and 120.5 running yds per outing so far this season. The Texans rank 9th in the NFL when examining opponents scoring, allowing 17.0 points per outing.

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The Jaguars step onto the field with a record of 1-1 on the season. The last time they stepped on the gridiron, the Jaguars took a loss by a score of 31-27 against the Cincinnati Bengals. Travis Etienne carried the ball 14 times for 71 yards, finishing the contest with 5.1 yds per carry for Jacksonville. Parker Washington was the best receiver for the Jaguars, catching 5 footballs for 76 yds (15.2 yds per catch). Trevor Lawrence (3 touchdowns) ended the game with 271 yards on 24-42 through the air while his quarterback rate was 80.6. He threw 2 picks and his avg yards per attempt was 6.5 yds. Jacksonville conceded 17 rushing attempts for 48 yards (2.8 yards per rush). The Jaguars passing defense gave up a completion rate of 62.2%, surrendering 302 yds on 28 out of 45 through the air. The Jaguars ended up finishing with 400 yds on 69 plays (5.8 yards per play). Jacksonville rushed the football for 5.1 yards per carry, finishing with 139 yds on 27 carries.

If you analyze their ability to score points, the Jaguars are ranked 7th in football, by tallying 26.5 PPG. For the season, the Jaguars have thrown for a total of 439 pass yds and average 219.5 pass yds per outing, ranking this team at 14th in the NFL. They average 169.5 rush yards per game, and have carried the football for 339 yards. The Jacksonville Jaguars hold an average of 389.0 yds per outing, which has them sitting 4th in the league. The Jacksonville offense has conceded 148 yds by way of 17 infractions, which has them sitting 7th in the league if you're looking at hurting your team. They have obtained 24 first downs as a unit.

They have allowed 4 touchdowns by way of the pass along with 222.0 pass yards per contest, ranking them 19th in the NFL. Jacksonville has relinquished a total of 161 running yds (80.5 total yards per outing), and 1 touchdown to rushers so far this season. The defense has attained 6 takeaways. Altogether, they have relinquished 41 total points. The Jaguars defense has been on the field for 126 plays, which is good for 20th in football. The Jaguars are conceding 20.5 PPG, ranking them 15th in football.

Who will win tonight's Texans-Jaguars NFL game against the spread?

Tony's Pick: Take the Jaguars -1

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