Las Vegas Raiders vs Indianapolis Colts Prediction, 10/5/2025 NFL Picks, Best Bets & Odds Week 5

Game: Las Vegas Raiders vs Indianapolis Colts

Date: Sunday, October 5, 2025

Location: Lucas Oil Stadium in Indianapolis, IN

TV: FOX

Odds-Point Spread: Colts (-7)

Total-Over-Under: 48

The Indianapolis Colts (3-1) will try to defeat the Las Vegas Raiders (1-3) at Lucas Oil Stadium on Sunday. Indianapolis opens this matchup as 7-point favorites. The over-under comes in at 48.

The Las Vegas Raiders step onto the field holding a record of 1-3 on the year. The last time they stepped on the gridiron, the Raiders went up against the Chicago Bears and ended up losing by a score of 25-24. Geno Smith went 14-21 with 117 yards through the air and 2 TDs. He had a QB rating of 73 and ended the contest with 3 picks. Brock Bowers left with an average of 9.2 yards per catch by totaling 46 yds on 5 receptions. Ashton Jeanty was the best rusher for the Raiders with 21 attempts for 138 yds (6.6 yards per carry). In the game, they tallied 52 plays for 357 yds. The Las Vegas Raiders rushed the ball a total of 31 different times and recorded 240 yds, which came out to an average of 7.7 yards per carry. Against the run, the Raiders gave up 69 yds on 26 tries, which averages out to 2.7 yards per run allowed. Las Vegas gave up 22 completions on 37 tries for a total of 202 yards, and a completion percentage of 59.5%.

Concerning scoring, the AFC members hold an average of 19.3 points per outing. Offensively, they're holding an average of 114.3 rushing yds which is good for 15th in professional football. The Raiders have compiled 1,318 total yards for this campaign. Las Vegas has notched 43 first downs as an offense, and they have been called for 25 infractions for 214 total yards. They have coughed up the ball 8 times (7 interceptions and 1 fumble). In terms of putting points on the board, Las Vegas currently has 6 passing TD's and 2 touchdowns via the ground.

The Raiders are sitting 22nd in football when it comes to their defensive abilities, granting 24.8 points per outing. The opposition is running for 4.0 yds per tote and 102.8 rushing yards per outing for this campaign. If you examine yards through the air, the Raiders have relinquished 913 total yards, putting them 23rd in the NFL. They have conceded 228.3 yards per outing via the pass, and are giving up a completion rate of 65.6%. In total, they are surrendering 331.0 total yards per contest, putting them 21st in the league. They have surrendered 5 touchdowns via the pass, in addition to 4 touchdowns via the rush. Overall, they have allowed 411 rushing yards through 4 games for the season.

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The Colts come into this matchup holding a record of 3-1 on the season. The last time they stepped on the gridiron, the Colts went home defeated by a final of 27-20 when they faced the Los Angeles Rams. Daniel Jones (1 touchdown) finished the game with 262 yds on 24-33 passing while his QB rating was 80.6. He threw 2 interceptions and his average yards per pass attempt was 7.9 yds. Jonathan Taylor carried the rock 17 times for 76 yards, walking away from the game with 4.5 yds per attempt for Indianapolis. Michael Pittman Jr. was one of the featured targets for the Colts, catching 5 throws for 41 yards (8.2 yards per catch). Indianapolis rushed for 4.0 yards per carry, finishing with a total of 85 yds on 21 attempts. The Colts finished the game with 333 yds while they ran 54 plays (6.2 yards per play). The Colts pass defense conceded a completion percentage of 70.7%, surrendering 360 yds on 29 for 41 through the air. Indianapolis surrendered 26 running attempts for 102 yards (3.9 yds per carry).

The Indianapolis Colts average 397.3 total yards per game, putting them 3rd in the NFL. They maintain an average of 136.3 rushing yards per contest, and have run for 545 yards. They have allowed 2 interceptions while yielding 1 fumble, and have recorded 51 first downs as an offense. The Indianapolis offense has relinquished 224 total yards by way of 30 infractions, putting them 14th in the NFL when examining hurting your team. This season, the Colts have compiled 1,044 pass yards and are sitting at 261.0 pass yards per contest, which has them ranked 4th in the NFL. When you look at this team's ability to score points, the Colts are ranking 4th in pro football, with an average of 30.8 points per contest.

They have allowed 8 touchdowns via the pass plus 223.8 yards through the air per game, which is 21st in football. Indianapolis has conceded a total of 384 rushing yards (96.0 yds per contest), along with 2 touchdowns by way of the ground game on the season. The defense has recorded 6 turnovers (2 forced fumbles and 4 interceptions) over the course of this season. Overall, they have given up 83 total points. The Colts defense has been on the field for 235 plays, which is good for 10th in professional football. The Colts are surrendering 20.8 points per game, putting them 12th in the league.

Who will win tonight's Raiders-Colts NFL game against the spread?

Josh's Pick: Take the Raiders +7

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