Los Angeles Chargers vs Miami Dolphins Prediction, 10/12/2025 NFL Picks, Best Bets & Odds Week 6

Game: Los Angeles Chargers vs Miami Dolphins

Date: Sunday, October 12, 2025

Location: Hard Rock Stadium in Miami Gardens, FL

TV: CBS

Odds-Point Spread: Dolphins (+4.5)

Total-Over-Under: 43.5

The Miami Dolphins (1-4) will compete against the Los Angeles Chargers (3-2) at Hard Rock Stadium on Sunday. Miami opens this game as 4.5-point underdogs from Vegas oddsmakers. The over-under is set at 43.5.

The Los Angeles Chargers head into this game 3-2 so far this season. In their last contest, the Chargers faced the Washington Commanders and ended up losing by a score of 27-10. Omarion Hampton led the offense in rushing for the Chargers with 12 totes for 44 yds (3.7 yards per carry). Omarion Hampton had an average of 4.3 yds per reception by earning 26 yds on 6 catches. Justin Herbert finished 22-29 with 166 yards through the air and 1 TD. He had a QB rating of 86.3 and finished the game with 1 pick. Against the run, the Chargers gave up 163 yards on 28 attempts, which is an average of 5.8 yards per run allowed. Los Angeles surrendered 15 pass completions on 26 tries for 226 yards, and a completion percentage of 57.7%. At the end of the game, they tallied 60 plays which gave them a total of 336 yds. The Los Angeles Chargers ran the football 27 times and tallied 155 yards, which had them averaging 5.7 yards per attempt.

With reference to putting the ball in the endzone, the AFC representatives are averaging 19.6 points per outing. As a unit, they maintain an average of 116.8 rushing yds which ranks them at 14th in football. The Chargers have accrued 1,761 yds for the year. Los Angeles has produced 60 1st downs offensively, and they have been hurt by 39 infractions for 299 total yards. They have surrendered the ball 7 different times (4 INTs and 3 lost fumbles). When you look at notching touchdowns, Los Angeles has recorded 8 touchdowns through the air and 2 touchdowns on the ground.

With reference to pass yards, the Chargers have conceded 861 yds, which is 6th in football. They have relinquished 172.2 total yards per contest through the air, and are giving up a completion% of 59.1%. In total, they have conceded 608 yards via the ground game in 5 games on the campaign. They have conceded 4 touchdowns through the air, as well as 5 touchdowns via the rush. Overall, they are allowing 293.8 total yards per contest, which ranks them at 7th in football. Opposing teams are running for an average of 4.8 yds per rush on the ground and 121.6 rush yds per outing for the year. The Chargers currently rank 7th in the NFL when you look at the other team scoring points, yielding 19.6 points per contest.

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The Dolphins come into this game with a record of 1-4 so far this season. In their last contest, the Dolphins went home defeated by a final of 27-24 when they faced the Carolina Panthers. De'Von Achane carried the football 10 times for 16 yards, walking away from the game with 1.6 yds per attempt for Miami. De'Von Achane was one of the featured targets for the Dolphins, snagging 6 passes for 30 yards (5.0 yards per catch). Tua Tagovailoa (3 touchdowns) finished the contest with 256 yds on 27-36 passing while his QB rating was 122. He didn't throw any interceptions and his avg yards per attempt was 7.1 yards. Miami conceded 32 run attempts for 239 yds (7.5 yards per rush). The Dolphins pass defense allowed a completion rate of 63.3%, surrendering 179 yds on 19 out of 30 passing. The Dolphins finished the contest with 248 yds on 50 plays (5.0 yds per play). Miami ended up running for 1.4 yards per attempt, totaling 19 yards on 14 attempts.

The Miami Dolphins average 278.6 total yards per outing, ranking this team at 28th in the NFL. They hold an average of 82.2 rushing yds per outing, and have run for 411 total yards. They have allowed 4 INTs while allowing 1 fumble, and have tallied 60 1st downs offensively. The Miami offense has yielded 241 total yards on 34 penalties, which has them sitting 21st in professional football when talking about hurting your team. On the campaign, the Dolphins have a total of 982 pass yards and average 196.4 pass yards per contest, which ranks them at 21st in football. When you look at their ability to score points, the Dolphins are 21st in the league, holding an average of 21.4 points per contest.

The Dolphins are allowing 29.0 points per contest, putting them 27th in the league. They have given up 9 touchdowns via the pass plus 212.4 yards through the air per outing, ranking them 16th in the NFL. Miami has granted a total of 871 running yards (174.2 yds per game), and 6 touchdowns by way of the ground game so far this season. The Dolphins defense has been on the field for 304 plays from scrimmage, which is 18th in professional football. The defense has amassed 5 turnovers (4 forced fumbles and 1 interception) over the course of this year. Overall, they have conceded 145 points in total.

Who will win tonight's Chargers-Dolphins NFL game against the spread?

Parlays Pundit's Pick: Take the Dolphins +4.5 and over 43.5 total points

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