Los Angeles Rams vs Philadelphia Eagles Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3

Game: Los Angeles Rams vs Philadelphia Eagles

Date: Sunday, September 21, 2025

Location: Lincoln Financial Field in Philadelphia, PA

TV: FOX

Odds-Point Spread: Eagles (-3.5)

Total-Over-Under: 44.5

The Los Angeles Rams (2-0) are en route to Lincoln Financial Field on Sunday where they will meet the Philadelphia Eagles (2-0). Philadelphia opens this contest as 3.5-point favorites from Vegas oddsmakers. The betting total is set at 44.5.

The Los Angeles Rams step onto the field holding a record of 2-0 over the course of this season. In their last game, the Rams faced the Tennessee Titans and walked away with a win by a score of 33-19. Matthew Stafford finished 23-33 with 298 yds through the air and 2 touchdowns. He had a quarterback rating of 105.4 and ended the contest with 1 interception. Kyren Williams led the offense in rushing for the Rams with 17 attempts for 66 yards (3.9 yds per carry). Davante Adams had an average of 17.7 yards per reception by accounting for 106 yards on 6 receptions. The Los Angeles Rams ran the football 25 different times and recorded 149 yards, which earned them an average of 6.0 yards per tote. Once the final whistle blew, they tallied 58 plays which gave them a total of 439 yds. Los Angeles relinquished 19 pass completions on 33 attempts for a total of 143 yds, and a completion percentage of 57.6%. In the running game, the Rams gave up 109 yds on 26 attempts, which is 4.2 yds per rush surrendered.

The Rams have earned 735 yards so far this season. Los Angeles currently has 25 first downs as a team, and they have been hurt by 11 infractions for 89 yards. If you examine scoring, Los Angeles currently has 3 touchdowns via the pass and 3 TD's on the ground. They have given the ball to the opposition 2 times (1 interception and 1 fumble). Offensively, they're averaging 110.5 rushing yards which is 16th in professional football. Regarding getting in the endzone, the Rams average 23.5 points per contest.

The Rams are sitting 1st in the league if you're looking at team defense, relinquishing 14.0 points per outing. The opposition is running for 4.2 yards per rushing attempt and 111.5 running yds per game on the season. Concerning yards via the pass, the Rams have allowed 294 yds, putting them 4th in pro football. They have granted 147.0 yds per outing through the air, and are surrendering a completion rate of 63.3%. In total, they are giving up 258.5 yds per contest, ranking them 4th in the league. They have allowed 1 touchdown by way of the pass. In total, they have surrendered 223 yards via the ground game in 2 matchups so far this season.

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The Eagles step onto the field with a record of 2-0 over the course of this year. The last time they stepped on the football field, the Eagles went home victorious with a score of 20-17 when they played the Kansas City Chiefs. Jalen Hurts ended the game with 101 yds on 15-22 through the air while his quarterback rating was 78. He didn't toss any picks and his average yards per pass attempt was 4.6 yards. Saquon Barkley ran the football 22 times for 88 yds, finishing the game with 4.0 yds per carry for Philadelphia. DeVonta Smith was featured in the passing game for the Eagles, snagging 4 passes for 53 yards (13.3 yds per reception). Philadelphia rushed the football for 3.6 yards per tote, totaling 122 yards on 34 attempts. The Eagles finished the contest with 216 yards and they ran 56 plays (3.9 yards per play). The Eagles passing defense allowed a completion percentage of 55.2%, surrendering 173 yds on 16 for 29 through the air. Philadelphia surrendered 26 attempts on the ground for 121 yds (4.7 yards per rush).

With reference to this team's ability to score points, the Eagles are ranking 16th in the NFL, averaging 22.0 points per contest. So far this season, the Eagles have a total of 238 pass yds and average 119.0 pass yds per game, which is good for 31st in football. They average 140.0 rushing yds per game, and have run for 280 yards. The Philadelphia Eagles hold an average of 259.0 yds per game, which is good for 29th in professional football. The Philadelphia offense has surrendered 158 total yards by way of 15 infractions, ranking this team at 14th in the NFL if you analyze hurting your team. They have been able to record 10 first downs as an offense.

They have allowed 1 touchdown via the pass in addition to 180.5 pass yards per game, which is good for 8th in professional football. Philadelphia has surrendered a total of 240 rush yards (120.0 yds per contest), in addition to 3 touchdowns by way of the ground game for the season. The defense has tallied 2 turnovers. Altogether, they have relinquished 37 total points. The Eagles defense has been on the field for 113 plays from the line of scrimmage, ranking this team at 8th in the NFL. The Eagles are giving up 18.5 points per game, ranking them 12th in the league.

Who will win tonight's Rams-Eagles NFL game against the spread?

Josh's Pick: Take the Eagles -3.5

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