New Orleans Saints vs Seattle Seahawks Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3

Game: New Orleans Saints vs Seattle Seahawks

Date: Sunday, September 21, 2025

Location: Lumen Field in Seattle, WA

TV: CBS

Odds-Point Spread: Seahawks (-7.5)

Total-Over-Under: 41.5

The New Orleans Saints (0-2) are on their way to Lumen Field on Sunday where they will try to defeat the Seattle Seahawks (1-1). Seattle opens this matchup as 7.5-point favorites from Vegas oddsmakers. The total is 41.5.

The New Orleans Saints come into this game holding a record of 0-2 over the course of this year. In their last game, the Saints took on the San Francisco 49ers and went home with a loss by a final score of 26-21. Alvin Kamara led the offense in rushing for the Saints with 21 totes for 99 yards (4.7 yards per carry). Chris Olave held an average of 9.0 yards per catch by earning 54 yds on 6 catches. Spencer Rattler finished 25-34 with 207 yds passing and 3 touchdowns. He had a quarterback rate of 118.1 and walked away from the contest without throwing a pick. On the ground, the Saints gave up 77 yards on 26 tries, which is an average of 3.0 yds per rush surrendered. New Orleans allowed 26 completions on 39 attempts for a total of 267 yards, and a completion percentage of 66.7%. When the final whistle blew, they ran 64 plays which converted into 307 yards. The New Orleans Saints ran the ball a total of 30 different times and totaled 121 yds, which came out to an average of 4.0 yards per carry.

Concerning putting points on the board, the NFC South members average 17.0 points per outing. Collectively, they maintain an average of 114.0 rushing yds ranking them 14th in football. The Saints have recorded 622 yards over the course of this year. New Orleans has racked up 24 1st downs offensively, and they have committed 20 infractions for 134 yards. They have surrendered the ball 1 time. With reference to scoring touchdowns, New Orleans has produced 3 touchdowns through the air and 1 rushing touchdown.

With reference to pass yards, the Saints have allowed 397 yards, ranking them 13th in the NFL. They have relinquished 198.5 yards per game by way of the pass, and are yielding a completion% of 69.1%. All in all, they have allowed 223 rushing yards through 2 outings over the course of this year. They have allowed 5 touchdowns by way of the pass. In total, they are giving up 310.0 yds per contest, ranking them 14th in the league. The opposition is running for an average of 4.2 yards per rush and 111.5 rushing yds per outing this year. The Saints are ranking 18th in the NFL if you examine the other team scoring points, surrendering 23.0 points per contest.

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The Seahawks step onto the field with a record of 1-1 on the season. The last time they took the field, the Seahawks went home victorious with a score of 31-17 when they faced the Pittsburgh Steelers. Kenneth Walker III carried the ball 13 times for 105 yds, finishing the game with 8.1 yards per carry for Seattle. Jaxon Smith-Njigba was the leading receiver for the Seahawks, hauling in 8 footballs for 103 yards (12.9 yards per catch). Sam Darnold (2 touchdowns) walked away from the contest with 295 yards on 22-33 passing while his quarterback rating was 89.8. He threw 2 picks and his average yards per pass attempt was 8.9 yds. Seattle gave up 21 rush attempts for 72 yds (3.4 yards per carry). The Seahawks passing defense conceded a completion percentage of 57.1%, relinquishing 195 yds on 20 for 35 through the air. The Seahawks finished the contest with a total of 395 yards while they ran 62 plays (6.4 yards per play). Seattle ran for 4.0 yds per carry, totaling 117 yds on 29 carries.

When examining the points being put on the board, the Seahawks currently sit 17th in football, with an average of 22.0 PPG. This year, the Seahawks have compiled 424 pass yds and hold an average of 212.0 pass yds per contest, ranking them 16th in the league. They hold an average of 100.5 rushing yds per outing, and have run for 201 yds. The Seattle Seahawks hold an average of 312.5 yds per game, which is good for 19th in professional football. The Seattle offense has allowed 40 yards by way of 6 violations, ranking them 32nd in the NFL if you examine helping out the opposition. They have earned 19 first downs.

They have surrendered 3 touchdowns by way of the pass in addition to 230.0 yards via the pass per game, ranking them 21st in football. Seattle has yielded a total of 191 rush yds (95.5 yards per outing). The D has notched 4 turnovers. On the whole, they have allowed 34 points. The Seahawks defense has participated in 131 plays, putting them 28th in pro football. The Seahawks are yielding 17.0 PPG, which is good for 8th in professional football.

Who will win tonight's Saints-Seahawks NFL game against the spread?

Josh's Pick: Take the Seahawks -7.5

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