San Francisco 49ers vs Seattle Seahawks Prediction, 9/7/2025 NFL Picks, Best Bets & Odds Week 1

Game: San Francisco 49ers vs Seattle Seahawks

Date: Sunday, September 7, 2025

Location: Lumen Field in Seattle, WA

TV: FOX

Odds-Point Spread: Seahawks (+2.5)

Total-Over-Under: 43.5

Lumen Field is the place where the Seattle Seahawks (10-7 last year) will go up against the San Francisco 49ers (6-11 last season) on Sunday. San Francisco opens this game as 2.5-point favorites from Vegas oddsmakers. The betting total is set at 43.5.

The San Francisco 49ers wrapped up their year having a 6-11 record. The last time they took the field, the 49ers went up against the Arizona Cardinals and took a loss by a score of 47-24. Patrick Taylor was the rushing leader for the 49ers with 17 carries for 109 yds (6.4 yds per carry). Ricky Pearsall held an average of 11.5 yds per catch by recording 69 yds on 6 receptions. Joshua Dobbs connected on 29-43 with 326 yards passing and 2 TDs. He had a quarterback rate of 86 and finished the game with 2 picks. In the running game, the 49ers gave up 151 yds on 27 attempts, which calculates to 5.6 yards per rush surrendered. San Francisco allowed 25 completions on 35 attempts for 242 yds, and a completion rate of 71.4%. For the game, they had 71 plays which totaled 436 yards. The San Francisco 49ers ended up rushing 28 times and amassed 138 yards, earning them an average of 4.9 yards per tote.

The 49ers earned 6,397 yds in the previous season. San Francisco had a total of 204 first downs as a team, and they were flagged for 111 infractions for 843 yds. San Francisco recorded 23 passing TD's and 17 rushing touchdowns. They gave the ball away 27 times (16 picks and 11 fumbles lost). Collectively, they were sitting at 127.2 rushing yds, which had them ranking 12th in professional football. When analyzing getting in the endzone, the San Francisco 49ers averaged 22.9 points per outing.

The 49ers were sitting 29th in the NFL when it comes to the other team scoring points, relinquishing 25.6 points per contest. They allowed 4.4 yards per attempt on the ground and 124.6 rushing yds per contest for last year. In total, they relinquished 2,118 rushing yards through 17 matchups for the previous season. If you examine passing yards, the 49ers conceded 3,278 total yards which had them sitting 5th in pro football. They surrendered 192.8 total yards per contest via the pass, and yielded a completion percentage 65.5%. All in all, they allowed 317.4 per contest, which had them sitting 8th in pro football. They surrendered 25 passing TD's, along with 24 via the rush.

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The Seahawks concluded the year having accumulated a 10-7 mark. In their last contest, the Seahawks walked away with a victory by a final of 30-25 when they faced the Los Angeles Rams. Zach Charbonnet ran the football 14 times for 59 yards, finishing the contest with 4.2 yards per carry for Seattle. Noah Fant had the best day in terms of receiving for the Seahawks, catching 5 balls for 63 yds (12.6 yds per catch). Geno Smith (4 TDs) ended the contest with 223 yards on 20-27 passing while his QB rate was 137.8. He didn't toss any picks and his avg yards per attempt was 8.3 yds. Seattle allowed 21 attempts on the ground for 84 yards (4.0 yards per rush). The Seahawks pass defense allowed a completion percentage of 65.9%, relinquishing 319 yds on 27 for 41 through the air. The Seahawks finished the game with a total of 336 yds on 51 plays (6.6 yards per play). Seattle rushed for 5.3 yards per tote, totaling 126 yds on 24 carries.

When analyzing the points being put on the board, the Seahawks sat 18th in professional football, by tallying 22.1 points per outing. For the prior year, the Seahawks racked up 4,020 passing yards and held an average of 236.5 passing yards per outing, which had them sitting 8th in pro football. They were sitting at 95.7 rushing yds per contest, and ran for 1,627 total yards. The Seattle Seahawks averaged 332.2 total yards per outing, which was 14th in professional football. The Seattle offense yielded 987 yards on 119 penalty flags, which had them ranking 5th in football regarding helping out the other team.

They allowed 26 touchdowns via the pass along with 211.9 passing yds per contest, which ranked them 11th in professional football. Seattle granted a total of 2,053 rushing yds (120.8 total yards per contest), along with 11 touchdowns via the rush for last year. The D recorded 18 takeaways (5 fumbles forced and 13 picks) for the previous season. The Seahawks defense participated in 1,065 plays from the line of scrimmage, ranking them 21st in football. The Seahawks conceded 21.6 points per contest, which had them sitting 12th in pro football.

Who will win tonight's 49ers-Seahawks NFL game against the spread?

Josh's Pick: Take the Seahawks +2.5

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