San Francisco 49ers vs Tampa Bay Buccaneers Prediction, 10/12/2025 NFL Picks, Best Bets & Odds Week 6

Game: San Francisco 49ers vs Tampa Bay Buccaneers

Date: Sunday, October 12, 2025

Location: Raymond James Stadium in Tampa, FL

TV: CBS

Odds-Point Spread: Buccaneers (-3)

Total-Over-Under: 47.5

The San Francisco 49ers (4-1) are on their way to Raymond James Stadium on Sunday where they will play the Tampa Bay Buccaneers (4-1). San Francisco is 3-point underdogs from oddsmakers. The total comes in at 47.5.

The San Francisco 49ers step on the gridiron 4-1 for the year. The last time they stepped on the gridiron, the 49ers took on the Los Angeles Rams and walked away with a win by a score of 26-23. Christian McCaffrey was the best rusher for the 49ers with 22 carries for 57 yds (2.6 yds per attempt). Kendrick Bourne averaged 14.2 yds per reception by accumulating 142 yards on 10 receptions. Mac Jones went 33-49 with 342 yards passing and 2 touchdowns. He had a QB rating of 100.9 and ended the contest with no interceptions. In the running game, the 49ers conceded 78 yards on 16 attempts, which calculates to 4.9 yards per run allowed. San Francisco relinquished 30 pass completions on 47 attempts for a total of 378 yards, and a completion percentage of 63.8%. In the game, they ran 82 plays which converted into 407 yards. The San Francisco 49ers ran the rock 33 different times and accounted for 74 yds, earning them an average of 2.2 yards per attempt.

The 49ers have a total of 1,879 total yards for the year. San Francisco has collected 80 1st downs as a team, and they have been hurt by 32 infractions for 268 yds. With reference to putting the ball in the endzone, San Francisco currently has 10 touchdowns through the air and 0 touchdowns on the ground. They have turned the football over 8 times (5 interceptions and 3 fumbles lost). Offensively, they hold an average of 85.2 rushing yds ranking them 28th in the NFL. If you're looking at getting the ball into the endzone, the 49ers are averaging 21.2 points per contest.

The 49ers currently sit 6th in pro football when analyzing their defensive prowess, granting 19.6 PPG. Opposing teams are running for an average of 4.1 yds per rush on the ground and 108.0 rush yds per outing for the year. With reference to pass yards, the 49ers have conceded 1,038 yds, which is 15th in football. They have granted 207.6 yds per outing through the air, and are surrendering a completion percentage of 67.1%. Overall, they are giving up 315.6 yds per outing, giving them a rank of 15th in football. They have granted 8 touchdowns via the pass, as well as 2 touchdowns on the ground. Altogether, they have relinquished 540 rushing yards through 5 outings for the year.

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The Buccaneers come into this game with a record of 4-1 so far this season. In their last contest, the Buccaneers got the win with a final of 38-35 against the Seattle Seahawks. Baker Mayfield (2 TDs) finished the contest with 379 yards on 29-33 passing while his quarterback rating was 134.7. He kept the ball away from the defense with no interceptions and his Y-A was 11.5 yards. Rachaad White carried the ball 14 times for 41 yds, ending the game with 2.9 yds per attempt for Tampa Bay. Emeka Egbuka was featured in the passing game for the Buccaneers, grabbing 7 balls for 163 yds (23.3 yds per catch). Tampa Bay rushed for 2.3 yds per attempt, finishing the contest with 56 yards on 24 attempts. The Buccaneers finished the contest with a total of 426 yards on 57 plays (7.5 yards per play). The Buccaneers pass defense conceded a completion percentage of 82.4%, relinquishing 341 yds on 28 out of 34 through the air. Tampa Bay conceded 20 run attempts for 122 yds (6.1 yards per rush).

The Tampa Bay Buccaneers hold an average of 353.8 total yards per contest, which has them sitting 11th in professional football. They hold an average of 110.4 running yds per contest, and have carried the football for 552 total yards. They have a total of 1 interception while allowing 1 fumble, and have tallied 58 first downs. The Tampa Bay offense has relinquished 306 total yards on 35 infractions, ranking this team at 18th in the NFL if you look at helping out the opposition. In this campaign, the Buccaneers have compiled 1,217 pass yards and are sitting at 243.4 pass yards per game, putting them 6th in the league. When you look at their ability to score points, the Buccaneers are 7th in the league, holding an average of 27.0 points per contest.

The Buccaneers are giving up 26.4 points per contest, giving them a rank of 23rd in football. They have given up 10 touchdowns via the pass plus 218.4 yards through the air per outing, ranking them 20th in the NFL. Tampa Bay has relinquished a total of 462 rush yds (92.4 total yards per outing), as well as 4 touchdowns via the rush for the year. The Buccaneers defense has been on the field for 292 plays from scrimmage, giving them a rank of 12th in football. The defense has produced 4 turnovers (2 forced fumbles and 2 picks) for this campaign. In total, they have conceded 132 pts.

Who will win tonight's 49ers-Buccaneers NFL game against the spread?

Josh's Pick: Take the Buccaneers -3

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