Tennessee Titans vs Indianapolis Colts Prediction, 10/26/2025 NFL Picks, Best Bets & Odds Week 8

Game: Tennessee Titans vs Indianapolis Colts

Date: Sunday, October 26, 2025

Location: Lucas Oil Stadium in Indianapolis, IN

TV: CBS

Odds-Point Spread: Colts (-14)

Total-Over-Under: 47

The Tennessee Titans (1-6) are en route to Lucas Oil Stadium on Sunday where they will compete against the Indianapolis Colts (6-1). Tennessee opens this matchup as 14-point underdogs from Vegas oddsmakers. The over-under comes in at 47.

The Tennessee Titans head into this game 1-6 so far this year. The last time they stepped on the football field, the Titans faced the New England Patriots and walked away from this one with a loss by a score of 31-13. Tyjae Spears was the leader on the ground for the Titans with 5 attempts for 22 yds (4.4 yds per carry). Elic Ayomanor left with an average of 14.5 yds per catch by earning 29 yards on 2 catches. Cam Ward connected on 25-34 with 255 yds passing and 1 TD. He had a quarterback rating of 92.2 and finished the contest with 1 pick. Against the rush, the Titans conceded 175 yards on 36 tries, which calculates to 4.9 yds per run surrendered. Tennessee surrendered 22 completions on 24 attempts for 212 yds, and a completion percentage of 91.7%. On the day, they ran 46 plays which gave them a total of 255 yds. The Tennessee Titans ran the football 12 times and amassed 39 yards, which is an average of 3.3 yards per carry.

When examining getting in the endzone, the AFC South members have an average of 13.7 PPG. As a team, they hold an average of 75.7 running yds which ranks them 31st in professional football. The Titans have recorded 1,649 yards on the season. Tennessee has notched 68 1st downs, and they have been flagged for 51 penalties for 380 yds. They have given the ball to the opposition 12 different times (5 picks and 7 fumbles). If you're looking at getting the ball in the endzone, Tennessee has produced 4 passing touchdowns and 2 touchdowns via the ground.

If you look at yards through the air, the Titans have given up 1,470 total yards, ranking this team at 16th in the NFL. They have given up 210.0 total yards per outing through the air, and are granting a completion rate of 73.2%. In total, they have granted 977 rushing yards through 7 matchups on the season. They have given up 9 touchdowns through the air, and 12 touchdowns to rushers. All in all, they are granting 349.6 yds per game, ranking them 24th in the league. The opposition is running for an average of 4.5 yards per run and 139.6 running yards per outing on the season. The Titans are 28th in pro football if you're looking at opponents scoring, granting 27.4 PPG.

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The Colts head into this matchup 6-1 for the year. The last time they took the field, the Colts took home the win by a final score of 38-24 against the Los Angeles Chargers. Daniel Jones (2 TDs) ended the contest with 288 yards on 23-34 passing while his quarterback rate was 113.4. He didn't toss any picks and his Y-A was 8.5 yds. Ameer Abdullah had the best day in terms of receiving for the Colts, catching 1 throws for 8 yards (8.0 yds per reception). Jonathan Taylor carried the football 16 times for 94 yards, finishing the contest with 5.9 yards per carry for Indianapolis. The Colts ended up finishing with 401 yds on 57 plays (7.0 yards per play). Indianapolis ran for 5.2 yds per carry, finishing with a total of 120 yards on 23 carries. Indianapolis relinquished 16 run attempts for 54 yds (3.4 yds per rush). The Colts passing defense gave up a completion rate of 67.3%, surrendering 391 yds on 37 out of 55 passing.

When analyzing putting points on the board, the Colts rank 1st in football, with an average of 33.1 PPG. Over the course of this season, the Colts have thrown for a total of 1,751 passing yds and have an average of 250.1 passing yds per game, which has them sitting 5th in the league. They average 130.1 running yds per contest, and have carried the football for 911 yds. The Indianapolis Colts average 380.3 yds per outing, which has them sitting 2nd in football. The Indianapolis offense has allowed 383 yds by way of 47 infractions, which is good for 17th in football if you're looking at making mistakes. They have compiled 3 interceptions while yielding 1 fumble, and have been able to record 90 first downs.

They have given up 13 touchdowns through the air as well as 255.4 yards through the air per outing, which has them sitting 29th in football. Indianapolis has relinquished a total of 632 running yards (90.3 total yards per outing), and 3 touchdowns on the ground for the year. Their defense has recorded 11 turnovers (2 forced fumbles and 9 interceptions) on the season. In total, they have yielded 140 pts. The Colts defense has participated in 444 plays from scrimmage, which is good for 25th in football. The Colts are surrendering 20.0 PPG, which is 9th in pro football.

Who will win tonight's Titans-Colts NFL game against the spread?

Guy's Pick: Take the Titans +14

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