Buffalo Bills vs Las Vegas Raiders Prediction, 10/18/2026 NFL Picks, Best Bets & Odds Week 6

Game: Buffalo Bills vs Las Vegas Raiders

Date: Sunday, October 18, 2026

Location: Allegiant Stadium in Las Vegas, NV

TV: CBS

Odds-Point Spread: Raiders +4.5

Total-Over-Under: 53

Allegiant Stadium is the site where the Las Vegas Raiders (3-2) will play the Buffalo Bills (4-1) on Sunday. Las Vegas is 4.5-point underdogs. The total comes in at 53.

The Buffalo Bills head into this matchup 4-1 for the season. In their last contest, the Bills faced off with the Los Angeles Rams and went home with a win by a final score of 37-34. Josh Allen led the offense in rushing for the Bills with 10 carries for 121 yds (12.1 yards per attempt). Khalil Shakir had an average of 26.7 yards per reception by tallying 80 yards on 3 catches. Josh Allen connected on 12-19 with 210 yds through the air and 1 touchdown. He had a QB rate of 96.4 and ended the contest with 1 pick. When it came to the battle of the line of scrimmage, the Bills conceded 77 yds on 23 tries, which averages out to 3.3 yards per run allowed. Buffalo surrendered 40 completions on 54 tries for 377 yards, and a completion percentage of 74.1%. In the game, they tallied 56 plays which gave them 436 yards. The Buffalo Bills ended up rushing 37 times and compiled 234 yds, which came out to an average of 6.3 yards per tote.

With reference to notching touchdowns, the AFC representatives are averaging 32.8 points per contest. As a unit, they have an average of 158.0 rushing yds ranking this team at 5th in football. The Bills have attained 1,981 yards on the year. Buffalo has recorded 53 first downs as a team, and they have been flagged for 43 infractions for 362 yards. They have given the ball to the opposition 9 times (4 picks and 5 fumbles lost). If you look at notching touchdowns, Buffalo has a total of 7 touchdowns via the pass and 13 rushing TD's.

Regarding yards through the air, the Bills have relinquished 1,402 total yards, ranking this team at 31st in football. They have allowed 280.4 yards per contest by way of the pass, and are surrendering a completion rate of 66.7%. In total, they have given up 541 yards via the running game in 5 outings for the season. They have allowed 13 touchdowns by way of the pass, along with 5 touchdowns via the rush. In total, they are conceding 388.6 yards per contest, which ranks 30th in the league. They are allowing 3.9 yds per running attempt and 108.2 rush yards per game over the course of this season. The Bills are sitting 28th in football if you look at opponents scoring, granting 28.2 points per contest.

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The Raiders step onto the field with a record of 3-2 on the year. In their last game, the Raiders took a defeat with a final score of 45-17 when they played the New England Patriots. Kirk Cousins (1 touchdown) ended the game with 243 yards on 19-28 passing while his quarterback rate was 106.7. He didn't toss any interceptions and his average yards per pass attempt was 8.7 yards. Ashton Jeanty carried the football 10 times for 27 yds, finishing the game with 2.7 yards per attempt for Las Vegas. Brock Bowers was one of the featured targets for the Raiders, grabbing 8 balls for 110 yards (13.8 yds per reception). Las Vegas rushed for 2.1 yards per attempt, finishing with 38 yards on 18 carries. The Raiders finished the game with 306 yards on 54 plays (5.7 yds per play). The Raiders secondary allowed a completion percentage of 76.5%, relinquishing 371 yds on 26 for 34 through the air. Las Vegas conceded 31 attempts on the ground for 165 yds (5.3 yds per carry).

Regarding their ability to score points, the Raiders are sitting 9th in the league, with 26.4 points per game. On the campaign, the Raiders sit at 1,268 passing yards and hold an average of 253.6 passing yards per outing, which ranks them at 8th in pro football. They average 82.0 rushing yds per contest, and have carried the football for 410 total yards. The Las Vegas Raiders have an average of 335.6 yds per game, which ranks them 14th in professional football. The Las Vegas offense has surrendered 221 yards by way of 31 violations, ranking them 26th in pro football when you look at helping out the other team. They have tossed 4 interceptions while relinquishing 3 lost fumbles, and have obtained 69 first downs.

The Raiders are conceding 25.8 points per contest, which ranks them at 22nd in pro football. They have relinquished 11 touchdowns through the air in addition to 236.4 yards through the air per contest, ranking this team at 24th in football. Las Vegas has relinquished a total of 703 rushing yds (140.6 yards per contest), plus 6 touchdowns on the ground for the season. The Raiders defense has participated in 308 plays from scrimmage, giving them a rank of 15th in football. Their defense has a total of 10 turnovers (6 forced fumbles and 4 interceptions) for the season. Altogether, they have yielded 129 total points.

Who will win tonight's Bills-Raiders NFL game against the spread?

Josh's Pick: Take the Raiders +4.5

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