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Buffalo Bills vs Denver Broncos Prediction, 1/17/2026 NFL Picks, Best Bets & Odds
by Tony Sink - 1/14/2026

The Buffalo Bills take on the Denver Broncos at Empower Field at Mile High in Denver, CO. Buffalo opens this matchup as 1.5-point underdogs. This matchup report includes NFL odds, predictions, and a free pick against the spread. Read More >>

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Buffalo Bills vs Jacksonville Jaguars Prediction, 1/11/2026 NFL Picks, Best Bets & Odds
by Josh Schonwald - 1/6/2026

EverBank Stadium is where the Jacksonville Jaguars (13-4) will meet the Buffalo Bills (12-5) on Sunday in an AFC Wild Card game. Jacksonville opens this matchup as 1.5-point dogs from oddsmakers. The betting total comes in at 51.5. This matchup report includes football betting lines and our pick of the day for this game. Read More >>

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New York Jets vs Buffalo Bills Prediction, 1/4/2026 NFL Picks, Best Bets & Odds Week 17
by Guy Bruhn - 1/2/2026

Highmark Stadium is where the Buffalo Bills (11-5) will attempt to defeat the New York Jets (3-13) on Sunday. New York is 6.5-point underdogs. The over-under is set at 38. This report includes betting predictions and our expert NFL picks for todays game. Read More >>

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Philadelphia Eagles vs Buffalo Bills Prediction, 12/28/2025 NFL Picks, Best Bets & Odds Week 17
by Josh Schonwald - 12/25/2025

The Buffalo Bills (11-4) will go up against the Philadelphia Eagles (10-5) at Highmark Stadium on Sunday. Buffalo opens as 1.5-point favorites from Vegas oddsmakers. The betting total comes in at 43.5. This report has odds and your NFL football predictions for todays game against the spread. Read More >>

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Buffalo Bills vs Cleveland Browns Prediction, 12/21/2025 NFL Picks, Best Bets & Odds Week 16
by Parlays Pundit - 12/18/2025

Huntington Bank Field is the location where the Cleveland Browns (3-11) will take on the Buffalo Bills (10-4) on Sunday. Cleveland opens this matchup as 10-point underdogs from Vegas oddsmakers. The total is set at 42. We have included an expert NFL pick and parlay for todays game against the spread. Read More >>

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Buffalo Bills vs New England Patriots Prediction, 12/14/2025 NFL Picks, Best Bets & Odds Week 15
by Guy Bruhn - 12/11/2025

The New England Patriots (11-2) will take on the Buffalo Bills (9-4) at Gillette Stadium on Sunday. Buffalo opens this game as 1-point favorites. The betting total is set at 49.5. This matchup report includes Vegas odds and a free NFL prediction for tonight. Read More >>

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Cincinnati Bengals vs Buffalo Bills Prediction, 12/7/2025 NFL Picks, Best Bets & Odds Week 14
by Guy Bruhn - 12/4/2025

Highmark Stadium is where the Buffalo Bills (8-4) will play the Cincinnati Bengals (4-8) on Sunday. Cincinnati opens this contest as 5.5-point dogs. The total has been set at 52.5. This matchup report includes Vegas odds and a free NFL pick for tonight. Read More >>

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Buffalo Bills vs Houston Texans Prediction, 11/20/2025 NFL Picks, Best Bets & Odds Week 12
by Tony Sink - 11/19/2025

The Houston Texans (5-5) will play the Buffalo Bills (7-3) at NRG Stadium on Thursday. Buffalo is 5.5-point favorites from Vegas oddsmakers. The betting total is set at 43.5. This matchup report includes NFL odds, predictions, and a free pick against the spread. Read More >>

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Tampa Bay Buccaneers vs Buffalo Bills Prediction, 11/16/2025 NFL Picks, Best Bets & Odds Week 11
by Parlays Pundit - 11/12/2025

The Buffalo Bills (6-3) will go up against the Tampa Bay Buccaneers (6-3) at Highmark Stadium on Sunday. Buffalo opens this contest as 5.5-point favorites. The over-under is 49. We have included an expert NFL pick and parlay for todays game against the spread. Read More >>

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Buffalo Bills vs Miami Dolphins Prediction, 11/9/2025 NFL Picks, Best Bets & Odds Week 10
by Parlays Pundit - 11/5/2025

The Miami Dolphins (2-7) will play the Buffalo Bills (6-2) at Hard Rock Stadium on Sunday. Buffalo opens this contest as 9.5-point favorites from oddsmakers. The total is set at 50. We have included an expert NFL pick and parlay for todays game against the spread. Read More >>

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Buffalo Bills vs Carolina Panthers Prediction, 10/26/2025 NFL Picks, Best Bets & Odds Week 8
by Josh Schonwald - 10/22/2025

The Buffalo Bills (4-2) are hitting the road to Bank of America Stadium on Sunday where they will try to beat the Carolina Panthers (4-3). Carolina is 7.5-point underdogs from Vegas oddsmakers. The betting total comes in at 45.5. This games report has current odds, betting predictions, and free picks against the spread. Read More >>

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Buffalo Bills vs Atlanta Falcons Prediction, 10/13/2025 NFL Picks, Best Bets & Odds Week 6
by Guy Bruhn - 10/7/2025

The Buffalo Bills (4-1) are headed to Mercedes-Benz Stadium on Monday where they will play the Atlanta Falcons (2-2). Atlanta opens this matchup as 4-point dogs. The over-under has been set at 48.5. This matchup report includes betting lines and our NFL pick of the day for this game. Read More >>

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New England Patriots vs Buffalo Bills Prediction, 10/5/2025 NFL Picks, Best Bets & Odds Week 5
by Tony Sink - 9/30/2025

The New England Patriots (2-2) are headed to Highmark Stadium on Sunday where they will compete against the Buffalo Bills (4-0). Buffalo is 7.5-point favorites. The total has been set at 49.5. This report includes betting odds and our expert football picks for todays game. Read More >>

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New Orleans Saints vs Buffalo Bills Prediction, 9/28/2025 NFL Picks, Best Bets & Odds Week 4
by Parlays Pundit - 9/23/2025

The New Orleans Saints (0-3) are traveling to Highmark Stadium on Sunday where they will attempt to defeat the Buffalo Bills (3-0). New Orleans opens as 16.5-point underdogs. The total has been set at 47.5. We have included an expert NFL pick and parlay for todays game against the spread. Read More >>

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Miami Dolphins vs Buffalo Bills Prediction, 9/18/2025 NFL Picks, Best Bets & Odds Week 3
by Tony Sink - 9/16/2025

The Buffalo Bills (2-0) welcome the Miami Dolphins (0-2) at Highmark Stadium on Thursday. Miami opens this matchup as 12.5-point underdogs from Vegas oddsmakers. The total is 49.5. This matchup report includes NFL odds, predictions, and a free pick against the spread. Read More >>

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Buffalo Bills vs New York Jets Prediction, 9/14/2025 NFL Picks, Best Bets & Odds Week 2
by Guy Bruhn - 9/9/2025

The New York Jets (0-1) host the Buffalo Bills (1-0) at MetLife Stadium on Sunday. Buffalo opens this game as 6.5-point favorites from Vegas oddsmakers. The over-under is 46. This matchup report has your NFL football pick of the day as well as NFL football odds for the game. Read More >>

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Baltimore Ravens vs Buffalo Bills Prediction, 9/7/2025 NFL Picks, Best Bets & Odds Week 1
by Josh Schonwald - 9/3/2025

The Baltimore Ravens (12-5 last season) are en route to Highmark Stadium on Sunday where they will meet the Buffalo Bills (13-4 last year). Buffalo opens as 1-point favorites from Vegas oddsmakers. The betting total is set at 50.5. This matchup report includes Vegas odds and a free NFL pick for tonight. Read More >>

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Buffalo Bills vs Kansas City Chiefs Prediction, 1/26/2025 NFL Picks, Best Bets & Odds AFC Championship
by Guy Bruhn - 1/20/2025

The Buffalo Bills (13-4) are en route to Arrowhead Stadium on Sunday where they will attempt to beat the Kansas City Chiefs (15-2). Buffalo opens this contest as 1.5-point underdogs from oddsmakers. The over-under is set at 47. This report includes betting predictions and our expert NFL picks for todays game. Read More >>

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Baltimore Ravens vs Buffalo Bills Prediction, 1/19/2025 NFL Picks, Best Bets & Odds Divisional Playoffs
by Josh Schonwald - 1/13/2025

The Buffalo Bills (13-4) will try to beat the Baltimore Ravens (12-5) at Highmark Stadium on Sunday. Baltimore is 1.0-point favorites. The total is set at 51. This matchup report includes football betting lines and our pick of the day for this game. Read More >>

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Denver Broncos vs Buffalo Bills Prediction, 1/12/2025 NFL Picks, Best Bets & Odds Wild Card
by Josh Schonwald - 1/6/2025

Highmark Stadium is the location where the Buffalo Bills (13-4) will meet the Denver Broncos (10-7) on Sunday. Buffalo is 8.5-point favorites. The betting total is set at 47. This matchup report includes football betting lines and our pick of the day for this game. Read More >>

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