Los Angeles Chargers vs Buffalo Bills Prediction, 9/27/2026 NFL Picks, Best Bets & Odds Week 3

Game: Los Angeles Chargers vs Buffalo Bills

Date: Sunday, September 27, 2026

Location: Highmark Stadium in Orchard Park, NY

TV: FOX

Odds-Point Spread: Bills -7.0

Total-Over-Under: 50

The Buffalo Bills (2-0) will play the Los Angeles Chargers (0-2) at Highmark Stadium on Sunday. Los Angeles opens this contest as 7-point underdogs from Vegas oddsmakers. The betting total is set at 50.

The Los Angeles Chargers come into this game holding a record of 0-2 over the course of the season. When they last took the field, the Chargers took the field against the Las Vegas Raiders and took a loss by a final of 26-14. Justin Herbert went 15-27 with 192 yards through the air and 1 touchdown. He had a quarterback rate of 59.5 and finished the contest with 2 picks. Omarion Hampton led the offense in rushing for the Chargers with 23 totes for 94 yards (4.1 yards per carry). Tre Harris averaged 53.0 yards per reception by earning 53 yds on 1 reception. The Los Angeles Chargers ended up running the ball 32 different times and accumulated 127 yards, which came out to an average of 4.0 yards per attempt. Once the final whistle blew, they tallied 59 plays which totaled 310 yds. Los Angeles allowed 19 pass completions on 29 tries for 248 yds, and a completion percentage of 65.5%. When it came to stopping the run, the Chargers gave up 57 yards on 29 tries, which averages out to 2.0 yds per rush allowed.

The Chargers have a total of 578 yards this year. Los Angeles has produced 17 1st downs, and they have been flagged for 15 infractions for 109 yards. Concerning scoring points, Los Angeles has produced 2 touchdowns via the pass and 2 touchdowns via the ground. They have coughed up the ball 5 different times (3 interceptions and 2 fumbles). Offensively, they are averaging 104.0 running yds which is 19th in the league. When examining putting the ball in the endzone, the AFC West members have an average of 14.0 PPG.

The Chargers currently rank 21st in football when examining opponents scoring, granting 26.0 points per outing. They are allowing teams to run for an average of 2.7 yards per attempt on the ground and 86.5 running yds per game for the year. When examining passing yards, the Chargers have given up 525 total yards, which is 29th in the league. They have allowed 262.5 total yards per contest through the air, and are surrendering a completion% of 69.7%. Overall, they are giving up 349.0 yds per contest, giving them a rank of 23rd in football. They have granted 4 touchdowns through the air, plus 1 touchdown to rushers. In total, they have conceded 173 yards via the running game in 2 games for this campaign.

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The Bills come into this game with a record of 2-0 for this campaign. In their last game, the Bills got the victory with a final of 41-31 when they faced the Detroit Lions. James Cook ran the football 21 times for 135 yards, ending the contest with 6.4 yards per attempt for Buffalo. Dalton Kincaid was a featured target for the Bills, snagging 7 passes for 95 yards (13.6 yards per catch). Josh Allen (3 TDs) ended the contest with 248 yards on 20-31 through the air while his QB rate was 121.4. He didn't throw any picks and his avg yards per attempt was 8.0 yds. Buffalo relinquished 20 attempts on the ground for 66 yards (3.3 yards per carry). The Bills passing defense allowed a completion percentage of 68.4%, surrendering 289 yards on 26 out of 38 through the air. The Bills finished the game with a total of 446 yards on 67 plays (6.7 yards per play). Buffalo ran the ball for 5.6 yds per carry, finishing the game with 203 yds on 36 attempts.

The Buffalo Bills maintain an average of 427.5 yds per contest, which has them sitting 2nd in football. They maintain an average of 144.5 rush yds per game, and have carried the football for 289 yards. They have compiled no picks while giving up no fumbles, and have obtained 27 1st downs offensively. The Buffalo offense has conceded 131 total yards on 15 penalties, ranking this team at 11th in the NFL with reference to helping out the opposition. On the year, the Bills have thrown for a total of 566 yards through the air and have an average of 283.0 yards through the air per game, which is good for 4th in the league. When talking about their ability to score points, the Bills currently rank 1st in the league, with 38.5 points per game.

They have given up 6 touchdowns by way of the pass along with 273.0 pass yds per outing, which is 30th in football. Buffalo has conceded a total of 190 rushing yds (95.0 yards per outing), and 2 touchdowns to rushers for the year. The D has produced 2 takeaways over the course of this season. Overall, they have granted 62 points. The Bills defense has taken the field for 135 plays from the line of scrimmage, which is 28th in football. The Bills are yielding 31.0 PPG, which is 30th in football.

Who will win tonight's Chargers-Bills NFL game against the spread?

Guy's Pick: Take the Bills -7.0

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