Buffalo Bills vs Los Angeles Rams Prediction, 10/12/2026 NFL Picks, Best Bets & Odds Week 5

Game: Buffalo Bills vs Los Angeles Rams

Date: Monday, October 12, 2026

Location: SoFi Stadium in Inglewood, CA

TV: ESPN

Odds-Point Spread: Bills +3.0

Total-Over-Under: 54

The Los Angeles Rams (2-2) will try to beat the Buffalo Bills (3-1) at SoFi Stadium on Monday. Los Angeles is 3-point favorites from oddsmakers. The total has been set at 54.

The Buffalo Bills head into this game 3-1 for this campaign. When they last stepped on the football field, the Bills took on the New England Patriots and ended up losing by a score of 29-26. Josh Allen went 23-33 with 253 yards passing and 1 touchdown. He had a quarterback rate of 89.6 and finished the game with 1 pick. James Cook led the offense in rushing for the Bills with 12 totes for 75 yds (6.3 yds per attempt). Keon Coleman held an average of 19.3 yds per catch by recording 116 yds on 6 catches. The Buffalo Bills ran the ball a total of 20 different times and had 91 yds, which had them averaging 4.6 yds per attempt. Once the final whistle blew, they tallied 53 plays which gave them a total of 340 yds. Buffalo allowed 22 completions on 37 attempts for 262 yards, and a completion percentage of 59.5%. On the ground, the Bills conceded 143 yards on 35 tries, which is 4.1 yards per run surrendered.

The Bills have attained 1,545 yards on the year. Buffalo has a total of 46 1st downs, and they have been hurt by 30 penalties for 250 total yards. When analyzing scoring touchdowns, Buffalo has accumulated 6 passing touchdowns and 10 touchdowns on the ground. They have given the ball to the opposition 7 times (3 picks and 4 lost fumbles). As a unit, they're holding an average of 139.0 rush yards which has them ranked 5th in pro football. If you look at getting the ball in the endzone, the AFC representatives have an average of 31.8 PPG.

The Bills currently rank 25th in the league concerning opponents scoring, conceding 26.8 PPG. They are allowing 4.0 yds per rushing attempt and 116.0 running yards per contest this year. If you analyze yards through the air, the Bills have relinquished 1,025 yards, which has them ranked 27th in pro football. They have surrendered 256.3 yds per outing via the pass, and are granting a completion rate of 63.9%. In total, they are surrendering 372.3 yards per contest, which has them ranked 27th in pro football. They have yielded 10 touchdowns by way of the pass, along with 3 touchdowns via the rush. In total, they have relinquished 464 yards via the ground game in 4 contests for the season.

Get all of our NFL Picks

The Rams come into this game with a record of 2-2 for the season. The last time they stepped on the football field, the Rams took home the win by a final score of 24-20 when they played the Philadelphia Eagles. Matthew Stafford finished the contest with 317 yards on 32-51 passing while his quarterback rate was 63.9. He tossed 2 interceptions and his avg yards per attempt was 6.2 yards. Kyren Williams ran the ball 16 times for 80 yards, finishing the contest with 5.0 yards per carry for Los Angeles. Puka Nacua was a featured target for the Rams, snagging 9 passes for 125 yards (13.9 yards per reception). Los Angeles rushed for 4.2 yards per carry, finishing the game with 106 yds on 25 attempts. The Rams finished the game with a total of 415 yds while running 76 plays (5.5 yards per play). The Rams pass defense conceded a completion rate of 44.4%, relinquishing 68 yards on 12 out of 27 passing. Los Angeles conceded 27 rushing attempts for 104 yards (3.9 yds per rush).

The Los Angeles Rams have an average of 417.0 yards per game, which is good for 2nd in the league. They average 126.8 rushing yards per outing, and have toted the ball for 507 yds. They have recorded 6 interceptions while surrendering 2 fumbles lost, and have obtained 56 first downs offensively. The Los Angeles offense has surrendered 284 total yards by way of 31 penalty flags, giving them a rank of 13th in the league concerning making mistakes. In this season, the Rams have earned 1,161 pass yds and are averaging 290.3 pass yds per contest, ranking them 2nd in the league. If you analyze their scoring prowess, the Rams currently sit 19th in the league, scoring 21.3 points per outing.

They have surrendered 7 touchdowns via the pass plus 145.5 yards via the pass per outing, putting them 2nd in football. Los Angeles has yielded a total of 408 running yds (102.0 yards per contest), in addition to 1 touchdown to rushers so far this year. Their defense has produced 3 takeaways this year. Overall, they have given up 83 points. The Rams defense has been on the field for 237 plays from the line of scrimmage, putting them 7th in football. The Rams are yielding 20.8 PPG, putting them 10th in football.

Who will win tonight's Bills-Rams NFL game against the spread?

Josh's Pick: Take the Bills +3.0

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get NFL picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.